Animal Model News and Research

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New insights into the mechanisms underlying progression of Huntington's disease

New research led by a University of Ottawa Faculty of Medicine team is providing compelling insights into the mechanisms underlying the progression of Huntington's disease in an animal model.

7 Jun 2023

How do antibiotics affect the ecology of the gut microbiome?

Each person's gut microbiome contains a specific community of microorganisms that normally remains stable for years. However, it can be thrown off balance by factors such as dietary changes, infections or medications. Antibiotics in particular have a strong influence on the microbiome. In response, microorganisms employ various resistance mechanisms, with individual bacterial populations evolving through selection of antibiotic-resistant variants. Yet, the extent and mechanisms of these processes and their impact on the ecology of the microbial community are poorly understood.

7 Jun 2023

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Acute myeloid leukemia (AML) is a very aggressive disease in which cells proliferate abnormally, invading the bone marrow and interfering with normal blood cell production. It is the most common acute leukemia in adults with the worst prognosis.

5 Jun 2023

Babies experiencing hypoxia due to sleep apnea tend to develop hypertension in adulthood

Newborn babies who experience low levels of oxygen in their body tissues (hypoxia) due to sleep apnea, for example, tend to develop respiratory problems and hypertension (high blood pressure) in adulthood, and these problems may persist for the rest of their lives.

31 May 2023

Innovative platform helps observe the fine details of luminal flow around the villi

Science is well aware of the important role that gut bacteria and their interactions with the gastrointestinal tract play in our overall health.

30 May 2023

Mice study shows how obstructive sleep apnea may affect gene activity throughout the day

The low blood oxygen levels of obstructive sleep apnea cause widespread changes in gene activity throughout the day, according to a new study in the open-access journal PLOS Biology by David Smith of Cincinnati Children's Hospital Medical Center, US, and colleagues.

30 May 2023

Change in liver clock could affect synchronization of the circadian cycle

Organisms rely on a biological clock known as the 'circadian' clock to regulate their activity according to the time of day.

17 May 2023

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Researchers generated six human monoclonal antibodies that prevented infection.

17 May 2023

Long-ignored antibiotic could help fight against multi-drug resistant bacteria

"The end of modern medicine as we know it." That's how the then-director general of the World Health Organization characterized the creeping problem of antimicrobial resistance in 2012.

16 May 2023

Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

Researchers discover how the A. baumannii can survive harsh environments

The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response.

16 May 2023

Study reveals how serotonin affects animal behavior at the whole-brain scale

Because serotonin is one of the primary chemicals the brain uses to influence mood and behavior, it is also the most common target of psychiatric drugs.

15 May 2023

Humanized mouse model for rare genetic disease developed for the first time

Mice with a defected human gene responsible for a rare genetic disease, called congenital adrenal hyperplasia, have been developed for the first time.

15 May 2023

Silenced p16 gene can drive colorectal cancer progression

Colorectal cancer is the fourth most common and second deadliest cancer. How colorectal cancer develops is not well understood, but a team led by researchers at Baylor College of Medicine reports in the Journal of Experimental & Clinical Cancer Research that silencing the gene p16, even though the DNA itself does not change, can drive colorectal cancer progression in animal models.

10 May 2023

Animal Model News and Research

New insights into the mechanisms underlying progression of Huntington's disease

How do antibiotics affect the ecology of the gut microbiome?

Research opens door to new, more efficient drug combinations for acute myeloid leukemia

Babies experiencing hypoxia due to sleep apnea tend to develop hypertension in adulthood

Innovative platform helps observe the fine details of luminal flow around the villi

Mice study shows how obstructive sleep apnea may affect gene activity throughout the day

Change in liver clock could affect synchronization of the circadian cycle

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Long-ignored antibiotic could help fight against multi-drug resistant bacteria

Mast cells play a crucial role in the development of chronic myeloid leukemia

Researchers discover how the A. baumannii can survive harsh environments

Study reveals how serotonin affects animal behavior at the whole-brain scale

Humanized mouse model for rare genetic disease developed for the first time

Silenced p16 gene can drive colorectal cancer progression

Study shows the power of gamma enhancement as potential approach for countering depression

Baylor scientists link MRTFB gene variants with novel neurodevelopmental disorder

NIH researchers identify new genetic risk factors for two types of non-Alzheimer's dementia

New research center aims to study the impact of everyday life stress on heart health

Advancing the development of vaccines through recombinant technology

Drugs targeting FXR1 may treat vascular proliferative diseases

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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