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UC research team uses zebrafish to study a gene mutation that causes congenital scoliosis

Popular in aquariums all over the world, the zebrafish is native to South Asia. But here in a Cincinnati Children's laboratory, the freshwater variant plays a vital role in scientific discovery.

22 Jan 2021

Gene editing shows potential to correct mutations causing inherited retinal degeneration

Gene editing therapies, including CRISPR-Cas systems, offer the potential to correct mutations causing inherited retinal degenerations, a leading cause of blindness.

20 Jan 2021

Gene-cutting system may play second role as a genetic dimmer switch

In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9 -- as a genetic dimmer switch for CRISPR-Cas9 genes.

19 Jan 2021

Study reveals significant role of ADAMTS1 protein in uveal melanoma

Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye.

15 Jan 2021

Researchers receive NIH grant to develop more effective flu vaccines

To build better vaccines, scientists want to know more about how our bodies make adequate numbers of effective, durable antibodies against the influenza virus.

11 Jan 2021

First steps toward uncovering CRISPR/Cas gene doping in plasma

All athletes want to be at the top of their game when they compete, but some resort to nefarious approaches to achieve peak muscle growth, speed and agility. Recent developments in gene editing technology could tempt athletes to change their DNA to get an edge.

6 Jan 2021

Researchers explain the role of enzyme that facilitates appropriate development of mouse embryo

The body plan of an organism, crafted over millennia of evolutionary trial and error, is so exquisitely fine-tuned that even a subtle deviation can be detrimental to individual survival and reproductive success.

17 Dec 2020

Networks of genes involved in congenital heart disease revealed

Over two million babies, children, and adults in the United States are living with congenital heart disease--a range of birth defects affecting the heart's structure or function.

14 Dec 2020

New method shortens the timeline to generate mice for vaccine research

To develop vaccines and investigate human immune responses, scientists rely on a variety of animal models, including mice that can produce human antibodies through genetically engineered B cell receptors, which are specialized antibodies bound to the B cell membrane.

14 Dec 2020

Reverse phenotyping shows reactive T cell profiles in SARS-CoV-2 infection

A new study appearing as a preprint on the medRxiv* browser in December 2020 employs reverse phenotyping technology to explore T cell responses in COVID-19.

10 Dec 2020

Scientists determine key molecular processes used by coronavirus to infect human cells

When a coronavirus--including SARS-CoV-2, which causes COVID-19--infects someone, it hijacks the person's cells, co-opting their molecular machinery for its own survival and spread.

9 Dec 2020

RNA mutations within common bacterium linked to invasive meningococcal disease

Researchers at Karolinska Institutet in Sweden have come one step closer toward understanding why some people become seriously ill or die from a common bacterium that leaves most people unharmed.

7 Dec 2020

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Imagine swabbing your nostrils, putting the swab in a device, and getting a read-out on your phone in 15 to 30 minutes that tells you if you are infected with the COVID-19 virus.

5 Dec 2020

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

A group of researchers developed a promising fix to CRISPR-Cas9's problem with unwanted genetic changes using a method that allows them to turn off gene-editing until it reaches key cell cycle phases where more accurate repairs are likely to happen.

4 Dec 2020

New CRISPR-Cas9 variant improves efficiency of gene editing tool

Using a new variant to repair DNA will improve both safety and effectiveness of the much-touted CRISPR-Cas9 tool in genetic research, Michigan Medicine researchers say.

3 Dec 2020

Researchers study SerpinB9 protein that could pave way to new immunotherapy approach

Immunotherapies have transformed the landscape of cancer treatment by allowing physicians to alter or augment patients' immune response to better attack malignant tumors.

2 Dec 2020

Researchers successfully edit SIV virus from genomes of non-human primates

Taking a major step forward in HIV research, scientists at the Lewis Katz School of Medicine at Temple University have successfully edited SIV - a virus closely related to HIV, the cause of AIDS - from the genomes of non-human primates.

1 Dec 2020

Scientists use large-scale method to study genes associated with autism spectrum disorder

Scientists at Harvard University, the Broad Institute of MIT and Harvard, and MIT have developed a technology to investigate the function of many different genres in many different cell types at once, in a living organism.

1 Dec 2020

New findings could pave the way for more effective, safer and cheaper gene therapy

In a promising advance for affordable, personalized medicine, researchers have used metal-organic frameworks to successfully deliver the genetic snipping tool CRISPR/Cas9 into human cancer cells.

20 Nov 2020

CRISPR/Cas9 system is highly effective in treating metastatic cancers

Researchers at Tel Aviv University (TAU) have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer.

19 Nov 2020