Cell Signaling News and Research

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Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

Study suggests average body temperature in humans falling

For decades, people have considered the average human body temperature to be 98.6 F, or 37 degrees Celsius. However, a new study published January 7, 2020, in the journal eLifeindicates this may no longer be the norm – and the researchers suggest a reason for their observed drop in average temperature.

13 Jan 2020

Researchers analyze molecular characteristics of cerebrospinal fluid from LMM patients

Patients with advanced melanoma who develop metastases in the leptomeninges, the fluid filled membranes surrounding the brain and spinal cord, have an extremely dismal prognosis. Most patients only survive for 8 to 10 weeks after diagnosis.

11 Jan 2020

Certain cancer drugs could be used in the future to treat COPD

New research has shown the potential for clinically available cancer treatments to treat chronic obstructive pulmonary disease.

6 Jan 2020

Scientists explain how a common virus causes havoc on bone marrow, organ transplant patients

For the first time, scientists have discovered the molecular mechanism behind how a common virus can wreak havoc on bone marrow and organ transplant patients, according to a paper published in the journal Cell & Host Microbe.

19 Dec 2019

New antibody shows promise in active lupus

A new trial involving the use of an antibody called anifrolumab reports improvement in patients with systemic lupus erythematosus (SLE) after 52 weeks of treatment. The research, titled 'Trial of Anifrolumab in Active Systemic Lupus Erythematosus', is published in the New England Journal of Medicine.

19 Dec 2019

Research finds key reason why brain connectivity goes awry in rare neurodevelopmental conditions

Axons are the long thread-like extensions of neurons that send electrical signals to other brain cells. Thanks to axonal connectivity, our brains and bodies can do all necessary tasks.

16 Dec 2019

Scientists uncover new link between pathways involved in RNA degradation

A recent study by a team of scientists in Korea reveals new findings about how various systems involved in cellular surveillance interact. This research is the first to identify a "cross-talk" molecule between these systems. Because these pathways are involved in fighting toxic cellular or foreign substances, the study has various potential applications in antiviral development, gene therapy, and agriculture.

6 Dec 2019

Attacking HIV at the source

A new study published on November 26, 2019, in the journal Cell Reports, details a new discovery that may help avert HIV infection right at the start. The virus is known to take a long time to infect a person, and the scientists say they have found a period during which it can be weakened or killed, in the very first hours after it has entered a host. They call this the window of vulnerability.

26 Nov 2019

Research shows how cilia and exocyst contribute to extracellular vesicle production

Although the cilium has been known to scientists for more than 100 years, it is only recently that it has been acknowledged to play important roles in physiology.

25 Nov 2019

UC Davis study identifies mechanism to rapidly repair leaky gut in monkeys with SIV infections

A UC Davis study found that the damaged gut lining (known as leaky gut) in monkeys infected with chronic simian immunodeficiency virus (SIV), an HIV-like virus, was rapidly repaired within five hours of receiving Lactobacillus plantarum bacteria.

19 Nov 2019

Uncovering the secret weapon of rabies viruses

In a new study published in the journal Cell Reports, scientists have discovered the exact site at which the immune system is disabled by the rabies virus, opening the way for a new and highly effective means of rabies prevention. This is a long-awaited discovery and could transform the field of rabies immunization.

13 Nov 2019

Contraceptive drug effective in preventing and regressing cervical cancer in mice

A new study in The American Journal of Pathology, published by Elsevier, reports that medroxyprogesterone acetate (MPA), the active ingredient in the common contraceptive injection Depo-Provera, was effective in preventing the development of cervical cancer in mice with precancerous lesions.

12 Nov 2019

Discovery of human cell signaling systems using bioinformatics

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are exploited by therapeutic drugs. In fact, one in three drugs makes use of receptors belonging to a single very large family – the GPCR (G protein receptor coupled receptor) family.

1 Nov 2019

Researchers identify new kidney cancer subtypes and clues to better diagnosis, treatment

In what is believed to be the most comprehensive molecular characterization to date of the most common - and often treatment-resistant - form of kidney cancer, researchers at Johns Hopkins' departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them.

From Johns Hopkins Medicine 31 Oct 2019

Novel method for aggressive breast cancer detection

A new study in rats published in the journal Cell Reports shows that the pattern of RNA molecules produced within certain immune cells called macrophages, found within breast cancers (tumor-associated macrophages, TAMs), can tell whether the tumor is cancerous or not and indicate the type of outcome. The same pattern is present in humans as in mice. This makes it directly useful in predicting the nature of a breast tumor and its outcome.

30 Oct 2019

Dynamic molecular signaling waves control embryonic fates

Timing is everything for young cells waiting to determine their identities.

29 Oct 2019

Scientists uncover how brain cells respond to and recover from lack of nutrition

We all know that food is essential to healthy development of the brain and body, especially in the earliest stages of life. But exactly how early brain growth is affected by nutrition is not as well understood, especially on a cellular level.

25 Oct 2019

Novel agent reduces buildup of toxic proteins in Parkinson's and Alzheimer's animal models

Neuroscientists at Georgetown University Medical Center say they have developed and tested an agent that reduces the buildup of toxic proteins in animal models of both Parkinson's and Alzheimer's diseases, and improves cognitive and motor behavior.

23 Oct 2019

Researchers receive $3.2 million NIH grant to pursue a deeper understanding of Down syndrome

Mount Sinai researchers have been awarded a $3.2 million grant from the National Institutes of Health to pursue a deeper understanding of Down syndrome, the most common genetic cause of intellectual and developmental disabilities in children and young adults, affecting more than 200,000 individuals in the United States.

22 Oct 2019

Building models to reconstruct evolutionary change more accurately than ever before

Remember domain, kingdom, phylum, class, order, family, genus, species and Darwin's tree of life metaphor we learned about in high school biology? That way of describing living-things lineages is just science's best guess about how genes have mutated and split over time to change things into what they are today.

17 Oct 2019

Cell Signaling News and Research

Further Reading

Study suggests average body temperature in humans falling

Researchers analyze molecular characteristics of cerebrospinal fluid from LMM patients

Certain cancer drugs could be used in the future to treat COPD

Scientists explain how a common virus causes havoc on bone marrow, organ transplant patients

New antibody shows promise in active lupus

Research finds key reason why brain connectivity goes awry in rare neurodevelopmental conditions

Scientists uncover new link between pathways involved in RNA degradation

Attacking HIV at the source

Research shows how cilia and exocyst contribute to extracellular vesicle production

UC Davis study identifies mechanism to rapidly repair leaky gut in monkeys with SIV infections

Uncovering the secret weapon of rabies viruses

Contraceptive drug effective in preventing and regressing cervical cancer in mice

Discovery of human cell signaling systems using bioinformatics

Researchers identify new kidney cancer subtypes and clues to better diagnosis, treatment

Novel method for aggressive breast cancer detection

Dynamic molecular signaling waves control embryonic fates

Scientists uncover how brain cells respond to and recover from lack of nutrition

Novel agent reduces buildup of toxic proteins in Parkinson's and Alzheimer's animal models

Researchers receive $3.2 million NIH grant to pursue a deeper understanding of Down syndrome

Building models to reconstruct evolutionary change more accurately than ever before

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo