Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Targeted degradation of Pin1 shows promise for pancreatic cancer treatment

In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins.

11 Nov 2024

New genetic model offers insights into breast cancer metastasis

A Michigan State University researcher's new model for studying breast cancer could help scientists better understand why and where cancer metastasizes.

11 Nov 2024

HMGB1 as a key mediator in liver disease pathogenesis

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality rates.

8 Nov 2024

Circulating tumor cells as a tool for early detection of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a significant global health concern, particularly in regions like the Asia-Pacific, where chronic viral hepatitis and liver diseases contribute to its high incidence and mortality.

8 Nov 2024

New research unravels mitochondria's role in breast cancer metastasis

Mitochondria have long been known as the tiny organelles that act as the battery packs inside our cells while also serving as internal sensors and communicators.

7 Nov 2024

Stanford researchers unveil the key role of extrachromosomal DNA in cancer

A trio of research papers from Stanford Medicine researchers and their international collaborators transforms scientists' understanding of how small DNA circles - until recently dismissed as inconsequential - are major drivers of many types of human cancers.

6 Nov 2024

AI-powered MRI predicts outcomes in prostate cancer

Researchers determine whether artificial intelligence-based MRI data could predict prostate cancer patient outcomes.

6 Nov 2024

New research uncovers 16 genes that aid breast cancer survival

Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to survive in the bloodstream after they've escaped the low-oxygen regions of a tumor.

5 Nov 2024

Unexpected immunotherapy success in rare pancreatic cancer

A new case report was published in Oncotarget's Volume 15 on October 11, 2024, entitled "A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy"

4 Nov 2024

Single-cell study identifies pro-metastatic cell subpopulations

Neuroblastoma (NB), the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to its metastasis and high heterogeneity. A recent study leveraging single-cell RNA sequencing (scRNA-seq) has uncovered vital molecular mechanisms underlying NB's progression and metastasis, shedding light on potential therapeutic targets.

3 Nov 2024

Combination therapy shows promising results in treating stage 3 melanoma

Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI).

1 Nov 2024

Mapping tumor microenvironments: Uncovering spatial subclones for improved cancer treatment

Researchers investigate the spatial organization of cancer cells and the tumor microenvironment.

31 Oct 2024

Successful treatment of metastatic malignant glomus tumor with BRAF and MEK inhibitors

A new case report was published in Oncotarget's Volume 15 on October 11, 2024, entitled "Complete response to encorafenib plus binimetinib in a BRAF V600E-mutant metastasic malignant glomus tumor."

29 Oct 2024

AI model could help clinicians to understand prostate tumor's aggressiveness

Prostate cancer is the second most common cancer in men, and almost 300,000 individuals are diagnosed with it each year in the U.S.

29 Oct 2024

Study identifies six cancer susceptibility genes

Identification of six cancer susceptibility genes offers new insights into genetic risk factors, potentially enhancing early detection and treatment strategies.

29 Oct 2024

New research unveils mechanism behind deadly neuroendocrine prostate cancer

A leading scientist whose discoveries about prostate cancer led to lifesaving treatments is now shedding light on an emerging and deadlier form of the disease: neuroendocrine prostate cancer (NEPC).

28 Oct 2024

RNA modifications and their role in cancer development

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications.

25 Oct 2024

3D-printed model created to mimic cancer metastasis

Scientists have created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells.

23 Oct 2024

P-stalk ribosomes identified as key regulators of immune evasion in cancer

Research uncovers how P-stalk ribosomes regulate cytokine responses, driving immune evasion in tumors across multiple cancer types. It offers new insights into post-translational mechanisms influencing immunotherapy success.

23 Oct 2024

Tissue stiffening linked to disease progression in HER2-negative breast cancer

A study published in Clinical Cancer Research confirmed that tissue stiffening in the most common types of breast cancer, HER2-negative, can directly cause disease progression and metastasis, leading to detrimental outcomes for patients.

22 Oct 2024