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Research opens up new therapeutic area to better manage chronic inflammatory diseases

Atherosclerosis is a disease defined by the accumulation of fatty deposits called plaques inside the arteries. It is a leading cause of heart attacks and strokes.

4 Feb 2019

Researchers use mouse models to explain the developmental process behind COPD

The airways and lungs are affected by a range of diseases, but while some have been well characterized and treated, others such as chronic obstructive pulmonary disorder (COPD) are still somewhat of an enigma.

1 Feb 2019

Researchers gain new insights into development of necrotizing enterocolitis in preemies

Researchers at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, and colleagues, discovered a promising direction toward understanding the development of necrotizing enterocolitis, a devastating intestinal disease commonly affecting premature infants, in order to treat it.

23 Jan 2019

Study reveals potential pathway for endothelial cells to avoid apoptosis

Cell death is an important aspect of tissue homeostasis, as well as inflammation and disease pathogenesis related to infection, injury, and tumor growth.

17 Jan 2019

Beckman Coulter launches new ClearLLab 10C System for clinical flow cytometry lab

Beckman Coulter launches the ClearLLab 10C System - the first 10-colour CE-IVD panels of immunophenotyping reagents for lymphoid and myeloid lineages.

From Beckman Coulter Life Sciences - Flow Cytometry 17 Jan 2019

New evidence shows how fever alters immune cells

Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how.

16 Jan 2019

Study: Rutin found in fruits and vegetables protect mice against snake venom

Rutin, a bioflavonoid found in certain vegetables and fruits, protects mice against snake venom by minimizing bleeding and inflammation, according to a study performed at the Butantan Institute, a research institution belonging to the government of São Paulo State in Brazil.

9 Jan 2019

Faulty immune receptor in HIV patients could be reason why many experience complications

For HIV patients, treatments that control the infection have come a long way. But many still struggle with a host of other disease-related complications such as neurocognitive disorders, cardiovascular issues, diabetes and chronic inflammation.

7 Jan 2019

Study uncovers how tumors backfire on neoadjuvant chemotherapy

Some patients with breast cancer receive chemotherapy before the tumor is removed with surgery. This approach, called 'neoadjuvant' therapy, helps to reduce the size of the tumor to facilitate breast-conserving surgery, and can even eradicate the tumor, leaving few or no cancerous cells for the surgeon to remove.

2 Jan 2019

Scientists discover cellular mechanism that triggers pneumonia in humans

The situation is relatively common, especially in winter. You come down with the flu, which lasts longer than usual. A few days later, you discover you have pneumonia.

10 Dec 2018

Eliminating microglia can reverse some aspects of stress sensitization, study shows

Using an animal model of chronic stress, researchers at The Ohio State University have shown that the immune cells of the brain, called microglia, hold unique signatures of chronic stress that leave the animal more sensitive to future stressful experiences, evident by increased anxiety and immune responses.

4 Dec 2018

First modeling system developed for testing age-specific human immune responses to vaccines

A team of scientists at Boston Children's Hospital has developed the first modeling system for testing age-specific human immune responses to vaccines -- outside the body. The practical, cost-effective new platform, using all human components, is expected to accelerate and de-risk the development, assessment and selection of vaccines.

20 Nov 2018

Replacement of dysfunctional microglia has therapeutic potential for neurodegenerative diseases

A new study by researchers at Karolinska Institutet supports the theory that replacement of dysfunctional immune cells in the brain has therapeutic potential for neurodegenerative diseases like ALS and Alzheimer's disease.

19 Nov 2018

New findings highlight importance of inflammatory component in atherosclerosis pathogenesis

One of the main characteristics of atherosclerosis is the accumulation of lipids in the intimal layer of the arterial wall.

29 Oct 2018

Targeting specific signaling pathway could provide new avenue for treating fetal alcohol syndrome

Fetal alcohol spectrum disorders are an array of conditions that can occur in a person whose mother consumed alcohol during pregnancy. Fetal alcohol syndrome, the most severe of these conditions, often results in physical abnormalities, behavioral development issues and intellectual disabilities.

24 Oct 2018

Potential 'early warning markers' for sepsis discovered

A multi-site research collaboration supported by a Technology Strategy Board Grant has shown that immune response signatures could be used as an early warning test for the serious condition sepsis in patients attending emergency departments with suspected infection.

15 Oct 2018

Ritual for orthodox Jewish men may offer cardiovascular health benefits, study suggests

A pilot study led by researchers at the University of Cincinnati College of Medicine suggests Jewish men who practice wearing tefillin, which involves the tight wrapping of an arm with leather banding as part of daily prayer, may receive cardiovascular health benefits.

11 Oct 2018

Study analyzes distribution of two cytokines in sections of carotid atherosclerotic plaques

Inflammation is currently a well-documented component of atheroslcerosis pathogenesis, which plays a role at each stage of the disease development.

6 Oct 2018

Study: Children with acute lymphoblastic leukemia are immunologically disparate at birth

Neonatal concentrations of eight detectable inflammatory markers were significantly different in children later diagnosed with B-cell precursor acute lymphoblastic leukemia (ALL) compared with controls.

14 Sep 2018

Study reveals mechanisms underlying inflammatory response in the brain associated with fever

Researchers from Kanazawa University report in Journal of Neuroscience performed a microdialysis study on mice to determine mechanisms underlying the inflammatory response in the brain associated with fever that might be used to develop new strategies for treatment.

31 Aug 2018