Rat Model News and Research

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Study reveals the mechanisms of sodium tungstate in treating diabetes

The molecular mechanisms of tungstate activity in diabetes have been uncovered. Researchers writing in the open access journal BMC Genomics have identified the pathways through which sodium tungstate improves pancreatic function and beta cell proliferation.

28 Aug 2009

Running and addiction

Although exercise is good for your health, extreme exercise may be physically addicting. Rats given a drug that produces withdrawal in heroin addicts went into withdrawal after running excessively in exercise wheels, according to new research. Rats that ran the hardest had the most severe withdrawal symptoms.

17 Aug 2009

Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis

Recently, the number of patients with GERD has increased in Japan. However, there have been few reports about the pathological findings in the esophageal squamous epithelium, and there are differing opinions among pathologists about the findings considered characteristic of chronic reflux esophagitis.

11 Aug 2009

New approach targets gut hormone to lower blood sugar levels

A research team led by Dr. Tony Lam at the Toronto General Research Institute and the University of Toronto discovered a novel function of a hormone found in the gut that might potentially lower glucose levels in diabetes.

6 Aug 2009

Discovery of novel function of hormone found in gut that may lower glucose levels in diabetes

5 Aug 2009

Grouping muscles to make controlling limbs easier

With more than 30 muscles in your arm, controlling movement -- whether it's grasping a glass or throwing a baseball -- is a complex task that potentially takes into account thousands of variables.

20 Apr 2009

Discovery of a new target for novel HIV treatment strategy

The AIDS-causing HIV specifically counteracts the mechanisms of human cells that protect these against viral infections - a special viral protein marks protective cellular proteins for their rapid destruction and thus diminishes the cell's supply.

15 Apr 2009

Soybean chemicals may reduce menopause symptoms

Soy aglycons of isoflavone (SAI), a group of soybean constituent chemicals, have been shown to promote health in a rat model of the menopause.

9 Apr 2009

Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as anti-inflammatory and analgesic agents.

2 Apr 2009

Carnitine supplementation appears to prevent development of liver cancer

A study will be published on March 21, 2009 in World Journal of Gastroenterology addresses the question.

24 Mar 2009

Research looks at protective effects of acupuncture against NSAID-induced ulceration in a rat model

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as anti-inflammatory and analgesic agents.

3 Mar 2009

New mechanistic explanation of how the brain interprets stress signals

Chronic stress takes a physical and emotional toll on our bodies and scientists are working on piecing together a medical puzzle to understand how we respond to stress at the cellular level in the brain.

2 Mar 2009

Blood pressure drug losartan may benefit brain tumor patients

A widely used blood pressure medication may be the key to preventing brain function loss common after radiation treatment, according to a newly published study by researchers at Wake Forest University Baptist Medical Center.

20 Feb 2009

Kynurenic acid in brain shows potential as schizophrenia target

New research has traced elevated levels of a specific compound in the brain to problem-solving deficits in patients with schizophrenia.

18 Nov 2008

Acologix demonstrates improved bone architecture in rat model of chronic kidney disease

Acologix, Inc. will present data indicating that its therapeutic product candidate AC-200 improved bone architecture in a rat model of chronic kidney disease.

8 Nov 2008

Maternal obesity can program fetal brain to induce adult-onset obesity

Researchers at the University at Buffalo have found that fetuses of obese mother rats were programmed in utero to develop obesity in adulthood.

5 Nov 2008

Maternal obesity can program fetal brain to induce adult-onset obesity

Researchers at the University at Buffalo have found that fetuses of obese mother rats were programmed in utero to develop obesity in adulthood.

4 Nov 2008

Viagra and Levitra ED drugs shown to allow more chemo to reach brain tumors

In a study using laboratory animals, researchers found that medications commonly prescribed for erectile dysfunction opened a mechanism called the blood-brain tumor barrier and increased delivery of cancer-fighting drugs to malignant brain tumors.

28 Jul 2008

Hydrogen sulfide significantly improves survival after extreme blood loss

For the first time, researchers have demonstrated that the administration of minute amounts of inhaled or intravenous hydrogen sulfide, or H2S - the molecule that gives rotten eggs their sulfurous stench - significantly improves survival from extreme blood loss in rats.

1 Jul 2008

CSL Behring study shows extended half-life recombinant VIIa leads to longer biologic activity

CSL Behring today presented results of a pre-clinical study that not only demonstrates the feasibility of genetically fusing factor VIIa to human albumin, but that this therapeutic protein with a prolonged half-life can lead to a longer biologic effect.

3 Jun 2008