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TUM scientists develop small molecule that may allow future patient-specific treatment of cancer tumours

Integrins help cells communicate with and adapt to their environment. Also cancer cells depend on their properties to survive and spread throughout the body. Now scientists at the Technical University of Munich have successfully developed a small, highly active molecule that binds to a specific integrin which operates in many types of cancer.

21 Dec 2015

TSRI-led study finds potential new therapeutic approach for hard-to-treat breast cancers

Findings from a new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) suggest a potent new therapeutic approach for a number of hard-to-treat breast cancers.

21 Dec 2015

Coffee may help improve athletic endurance

The caffeine in a morning cup of coffee could help improve athletic endurance, according to a new University of Georgia review study.

20 Dec 2015

DS Biopharma reports completion of DS102 Phase I trial for treatment of fatty liver disorders

DS Biopharma, a privately held biopharmaceutical company, today announced the successful completion of a Phase I trial with an oral formulation of the active pharmaceutical ingredient DS102 (15-HEPE) which is being explored for the treatment of fatty liver disorders, such as non-alcoholic steatohepatitis (NASH) and pulmonary disorders, such as idiopathic pulmonary fibrosis (IPF).

18 Dec 2015

UB study traces how enigmatic molecules help cancer self-destruct

You've probably never heard of "sphingolipids" before. But these curiously named organic compounds play a vital role in one of humanity's most well-known diseases: cancer.

18 Dec 2015

Findings show promising evidence for creating broad-spectrum antiviral

UW researchers working in collaboration with Kineta Inc. and the University of Texas at Galveston have shown that making a drug-like molecule to turn on innate immunity can induce genes to control infection in several -known viruses.

18 Dec 2015

UCA researchers identify compounds that favour generation of new neuronal cells

Many neurology pathologies cause irreversible loss of neurons. They are mostly the so-called neurodegenerative diseases although there exist other causes for a focal loss of neurons, as it is the case in strokes or traumatic brain injuries. All these pathologies lack nowadays of an efficient treatment not being possible to regenerate dead neurons. In fact, although the brain has the ability to regenerate as many studies has proved, this regeneration is very low, ranging from 0.2% to a maximum of 10% depending on the type of injury and the damaged area.

17 Dec 2015

Louisville researchers move closer to potential treatment for gum disease

University of Louisville researchers recently received a patent on a synthetic biochemical compound and its variants, moving science closer to a treatment for gum disease. This discovery could lead to the formulation of a mouth rinse or tooth varnish to prevent the pathogen, P. gingivalis from colonizing in the mouth and establishing itself orally.

17 Dec 2015

New funding supports research on new and improved drug treatments for tuberculosis, malaria

University of Toronto and McGill University scientists are leading an international partnership to discover new and improved drug treatments for tuberculosis, malaria and neglected tropical diseases -- thanks to a contribution from Merck Canada Inc., as well as an additional $5 million supplement to a grant from the Bill & Melinda Gates Foundation.

17 Dec 2015

Bile acid may help treat fatty liver disease and obesity

A bile acid that can turn off a receptor in the gut has prevented and reversed fatty liver disease in mice, according to an international team of researchers. The compound may help treat certain metabolic disorders, such as Type 2 diabetes and obesity, as well.

16 Dec 2015

Liver protein aids in accelerating growth of insulin-producing pancreatic 'beta' cells

More than a quarter of the 30 million people with diabetes in the United States depend on daily injections of insulin to maintain their blood glucose levels in a healthy range. Scientists are investigating many techniques to help treat or potentially even cure many of these patients by increasing the body's own insulin-producing pancreatic "beta" cells.

15 Dec 2015

New chemical method developed to introduce alkenes into simple hydrocarbon molecules

Chemists at Princeton have developed a new chemical method to introduce valuable alkenes into simple hydrocarbon molecules, a transformation known as dehydrogenation, which is found in important processes such as the biosynthesis of essential fatty acids in the body and the commercial production of detergents.

13 Dec 2015

Apigenin improves neuron formation, strengthens connections between brain cells

Brazilian researchers from D'Or Institute for Research and Education, Federal University of Rio de Janeiro and Federal University of Bahia have demonstrated in laboratory that apigenin, a substance found in parsley, thyme, chamomile and red pepper, improves neuron formation and strengthens the connections between brain cells.

11 Dec 2015

Cancer drug can neutralize toxic RNA that causes myotonic dystrophy

A group of researchers has shown for the first time in cells and in a mouse model that a drug used to treat cancer can neutralize the toxic RNA that causes the prolonged muscle contractions and other symptoms of myotonic dystrophy type 1, the most common form of adult-onset muscular dystrophy.

11 Dec 2015

New prosthesis brings hope to patients with hearing loss

A new prosthesis for a traditional ear surgery is bringing hope to patients diagnosed with a hereditary disorder that causes hearing loss. After 63-year-old Diane Duncan was diagnosed with otosclerosis in her thirties, she transitioned into an isolated world where conversations with other people became limited, everyday noises like car engines running and cell phones ringing became almost inaudible.

10 Dec 2015

Tetra begins human Phase 1 safety trials of BPN14770

Tetra Discovery Partners today announced that the company has initiated human Phase 1 safety trials of its lead compound BPN14770, which Tetra is developing as a potential treatment to both improve memory and slow the progression of Alzheimer's disease.

9 Dec 2015

New drug therapies that target glutamate pathway may be effective for subgroups of patient with schizophrenia

Mounting evidence indicates that disturbances in the brain's glutamate pathway contribute to symptoms of schizophrenia. Thus, the glutamate pathway has become the target of a number of new drug therapies. Findings published in the journal Biological Psychiatry suggest that at least one of these drugs may be an effective treatment for individuals in the early course of the illness.

9 Dec 2015

Novel antidepressant appears to be safe, effective against depression in clinical trial

A small clinical trial of a novel antidepressant that stimulates neurogenesis - the production of new brain cells - shows that the compound appears to be safe and may be effective against depression.

9 Dec 2015

Existing compound offers hope for slowing Huntington's disease progression

Currently, there is no treatment to halt the progression of Huntington's disease (HD), a fatal genetic disorder that slowly robs sufferers of their physical and mental abilities. Now, researchers at University of California, San Diego School of Medicine have discovered that an existing compound, previously tested for diabetes, offers hope for slowing HD and its symptoms.

8 Dec 2015

Pediatric chemotherapy regimen improves outcomes in young adults with ALL

Using a pediatric chemotherapy regimen to treat young adults with acute lymphoblastic leukemia (ALL) significantly improved their outcomes compared to what has historically been achieved with 'adult' treatment protocols, report Dana-Farber Cancer Institute scientists.

8 Dec 2015

Compound News and Research

TUM scientists develop small molecule that may allow future patient-specific treatment of cancer tumours

TSRI-led study finds potential new therapeutic approach for hard-to-treat breast cancers

Coffee may help improve athletic endurance

DS Biopharma reports completion of DS102 Phase I trial for treatment of fatty liver disorders

UB study traces how enigmatic molecules help cancer self-destruct

Findings show promising evidence for creating broad-spectrum antiviral

UCA researchers identify compounds that favour generation of new neuronal cells

Louisville researchers move closer to potential treatment for gum disease

New funding supports research on new and improved drug treatments for tuberculosis, malaria

Bile acid may help treat fatty liver disease and obesity

Liver protein aids in accelerating growth of insulin-producing pancreatic 'beta' cells

New chemical method developed to introduce alkenes into simple hydrocarbon molecules

Apigenin improves neuron formation, strengthens connections between brain cells

Cancer drug can neutralize toxic RNA that causes myotonic dystrophy

New prosthesis brings hope to patients with hearing loss

Tetra begins human Phase 1 safety trials of BPN14770

New drug therapies that target glutamate pathway may be effective for subgroups of patient with schizophrenia

Novel antidepressant appears to be safe, effective against depression in clinical trial

Existing compound offers hope for slowing Huntington's disease progression

Pediatric chemotherapy regimen improves outcomes in young adults with ALL

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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