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Exploring links between stress, choline deficiency, preterm births, and mental illness

In two recent articles published in Schizophrenia Bulletin, Sharon Hunter, PhD, an associate professor in the University of Colorado School of Medicine Department of Psychiatry, and M. Camille Hoffman, MD, MSc, an associate professor in the University of Colorado School of Medicine Department of Obstetrics and Gynecology, along with their research group, have uncovered a potential link between choline deficiency in Black pregnant women in the United States and increased risk of developmental and behavioral issues that can evolve into mental illness later in their children's lives.

7 Jul 2021

Research shows how loss of de-N-glycosylation enzyme causes detrimental effects

Peptide: N-glycanase (NGLY1) is an evolutionarily conserved enzyme for removing N-linked glycans (N-glycans) from glycoproteins and is involved in proteostasis of N-glycoproteins in the cytosol. In 2012, a rare genetic disorder called NGLY1 deficiency was discovered by an exome analysis.

7 Jul 2021

Shape of extracellular vesicles in body fluids could be a biomarker for identifying cancer types

A recent study by scientists from Japanese universities has shown that the shape of cell-derived nanoparticles, known as "extracellular vesicles" (EVs), in body fluids could be a biomarker for identifying types of cancer.

7 Jul 2021

Adults with ADHD at higher risk of many physical conditions, finds study

Adults with ADHD are at higher risk of a wide range of physical conditions, including nervous system, respiratory, musculoskeletal, and metabolic diseases, according to a large register-based study from Karolinska Institutet in Sweden published in The Lancet Psychiatry.

7 Jul 2021

NYUAD researchers unlock an epigenetic code that allows liver regeneration

NYU Abu Dhabi researchers uncovered a code that sets the genome of the liver to account for the remarkable ability for this organ to regenerate.

6 Jul 2021

22 blood plasma lipids found to be associated with lower symptom improvement in schizophrenia

Researchers from Skoltech and the Mental Health Research Center have found 22 lipids in the blood plasma of people with schizophrenia that were associated with lower symptom improvement over time during treatment.

6 Jul 2021

A new method for generating metabolic profiles of single cells

Scientists from the European Molecular Biology Laboratory and the German Cancer Research Center have presented a new method for generating metabolic profiles of individual cells.

6 Jul 2021

Deletion of an embryonic gene in liver cells completely wipes out bile ducts of newborn mice

Scientists from the University of Pittsburgh School of Medicine described a new phenomenon in which the deletion of a single gene involved in liver embryogenesis completely wipes out bile ducts of newborn mice.

6 Jul 2021

Two chemoattenuated PfSPZ malaria vaccines provide strong and lasting protection

A team of researchers recently optimized regimens for CVac, wherein aseptic, purified, cryopreserved, and infectious PfSPZ were inoculated and mixed with PYR and CQ.

5 Jul 2021

New study attempts to characterize long-COVID in all its complexity

In a new meta-study, a large subset of reports on post-viral complications in individuals following a SARS-CoV-2 infection have been organized and categorized, mapping 287 unique clinical findings related to long-COVID.

5 Jul 2021

COVID-19 vaccination induces highly variable immunity among the immunocompromised

Researchers in the United States have conducted a study showing that the humoral (antibody) immunity induced by vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – varies significantly among immunocompromised individuals.

4 Jul 2021

New immunotherapy treatment for cancer patients is more effective and less dangerous

Cell toxicity during immunotherapy is a major limitation to cancer treatment.

2 Jul 2021

Researchers seek to quantify immunogenicity of COVID vaccines in immunocompromised patients

Evidence continues to mount that vaccination against COVID-19, most notably the Pfizer and Moderna vaccines, produces robust, durable protection in the vast majority of recipients.

2 Jul 2021

New malaria vaccine is undergoing Phase 1 trials but current results show it provides strong and long-lasting protection

A new malaria vaccine could be the breakthrough in developing an effective and lasting treatment.

1 Jul 2021

Novel candidate malaria vaccine confers high levels of durable protection

Two U.S. Phase 1 clinical trials of a novel candidate malaria vaccine have found that the regimen conferred unprecedentedly high levels of durable protection when volunteers were later exposed to disease-causing malaria parasites.

30 Jun 2021

FDA approves alternative component of chemotherapy regimen to treat acute lymphoblastic leukemia

Today, the U.S. Food and Drug Administration approved Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn) as a component of a chemotherapy regimen to treat acute lymphoblastic leukemia and lymphoblastic lymphoma in adult and pediatric patients who are allergic to the E. coli-derived asparaginase products used most commonly for treatment.

30 Jun 2021

Higher risk of cardiovascular disease associated with ‘Southern’ diet of fried food, fats, and sugary drinks

New research has supported the trends that regularly consuming a diet of fried food, meat, sugary drinks may increase the risk of sudden cardiac death.

30 Jun 2021

Scientists outline new target for treating type 2 diabetes

This year marks the 100th anniversary of the discovery of insulin, a scientific breakthrough that transformed Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, from a terminal disease into a manageable condition.

30 Jun 2021

CN Bio’s PhysioMimix™ adopted by King’s College London to investigate chronic liver disease

CN Bio today announced that King’s College London, an internationally renowned research university, has adopted the PhysioMimix™ Multi-Organ MPS.

From CN Bio 29 Jun 2021

New study reveals how heparan sulfate promotes amyloid deposition in various organs

Amyloid diseases, including Alzheimer's, Parkinson's, type-2 diabetes and other life-threatening diseases, involve pathologic deposits of normally soluble proteins or peptides as insoluble amyloid fibrils. When this happens in vital organs, such as the brain, kidney, liver and heart, it causes organ damage and, if left untreated, death. Unfortunately, the available treatment options are very limited.

29 Jun 2021

Liver News and Research

Exploring links between stress, choline deficiency, preterm births, and mental illness

Research shows how loss of de-N-glycosylation enzyme causes detrimental effects

Shape of extracellular vesicles in body fluids could be a biomarker for identifying cancer types

Adults with ADHD at higher risk of many physical conditions, finds study

NYUAD researchers unlock an epigenetic code that allows liver regeneration

22 blood plasma lipids found to be associated with lower symptom improvement in schizophrenia

A new method for generating metabolic profiles of single cells

Deletion of an embryonic gene in liver cells completely wipes out bile ducts of newborn mice

Two chemoattenuated PfSPZ malaria vaccines provide strong and lasting protection

New study attempts to characterize long-COVID in all its complexity

COVID-19 vaccination induces highly variable immunity among the immunocompromised

New immunotherapy treatment for cancer patients is more effective and less dangerous

Researchers seek to quantify immunogenicity of COVID vaccines in immunocompromised patients

New malaria vaccine is undergoing Phase 1 trials but current results show it provides strong and long-lasting protection

Novel candidate malaria vaccine confers high levels of durable protection

FDA approves alternative component of chemotherapy regimen to treat acute lymphoblastic leukemia

Higher risk of cardiovascular disease associated with ‘Southern’ diet of fried food, fats, and sugary drinks

Scientists outline new target for treating type 2 diabetes

CN Bio’s PhysioMimix™ adopted by King’s College London to investigate chronic liver disease

New study reveals how heparan sulfate promotes amyloid deposition in various organs

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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