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OncoSec Medical signs Sponsored Research Agreement with ODU for melanoma study

OncoSec Medical Inc., a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumors, signed a Sponsored Research Agreement with Old Dominion University and the Frank Reidy Research Center for Bioelectrics.

11 Jun 2013

Scientists find that mice develop age-related progressive motor symptoms of Parkinson's disease

The presence of Lewy bodies in nerve cells, formed by intracellular deposits of the protein α-synuclein, is a characteristic pathologic feature of Parkinson's Disease (PD). In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α-synuclein.

10 Jun 2013

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

A drug used to control Type II diabetes can help repair the spinal cords of mice suffering from the inherited disease adrenoleukodystrophy which, untreated, leads eventually to a paralysis, a vegetative state and death.

10 Jun 2013

Optogenetics: A promising technique for treatment of obsessive-compulsive disorders

By applying light stimulation to highly specific neurons in the brain, the researchers managed to re-establish normal behaviour in mice that had beforehand presented pathological repetitive behaviour similar to that observed in human patients suffering from obsessive-compulsive disorders.

10 Jun 2013

Liver regeneration using cell therapy may be possible, study suggests

Liver transplantation is the mainstay of treatment for patients with end-stage liver disease, the 12th leading cause of death in the United States, but new research from the Icahn School of Medicine at Mount Sinai, published in the online journal Cell Stem Cell today, suggests that it may one day become possible to regenerate a liver using cell therapy in patients with liver disease.

10 Jun 2013

Discovery of impaired molecular pathway may help treat children with leukemia

Through genetic engineering of laboratory models, researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center have uncovered a vulnerability in the way cancer cells diverge from normal regenerating cells that may help treat children with leukemia as reported in the journal PNAS on June 3, 2013.

7 Jun 2013

Medicago reports positive interim results from preclinical trial for H7 VLP vaccine candidate

Medicago Inc., a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles, today reported positive interim results from a preclinical trial for an H7N9 Avian Influenza VLP vaccine candidate ("H7 vaccine").

6 Jun 2013

UCLA researchers identify abnormal brain networks in Fragile X syndrome

The genetic malady known as Fragile X syndrome is the most common cause of inherited autism and intellectual disability. Brain scientists know the gene defect that causes the syndrome and understand the damage it does in misshaping the brain's synapses - the connections between neurons. But how this abnormal shaping of synapses translates into abnormal behavior is unclear.

5 Jun 2013

Researchers establish link between abnormal structure of synapses and behavioral abnormalities of brain circuits in FXS

Fragile X syndrome (FXS) is a genetic malady that is the most common inherited cause of autism and intellectual disability. Brain scientists know the gene defect that causes FXS, and the damage it does-- misshaping the brain's synapses, the connections between neurons. But how that abnormal shaping of synapses translates to abnormal behavior is unclear.

4 Jun 2013

Growth factor helps hair follicles regenerate during wound healing process, say researchers

Researchers in the Perelman School of Medicine at the University of Pennsylvania have determined the role of a key growth factor, found in skin cells of limited quantities in humans, which helps hair follicles form and regenerate during the wound healing process.

3 Jun 2013

Researchers show interleukin-22 guards against bacterial superinfections that can arise after influenza

Researchers from the Pasteur Institute, Lille, France have shown in a mouse model that interleukin-22 protects against bacterial superinfections that can arise following influenza.

31 May 2013

Findings could lead to better understanding of learning and memory

Students preparing for final exams might want to wait before pulling an all-night cram session - at least as far as their neurons are concerned. Carnegie Mellon University neuroscientists have discovered a new intermediate phase in neuronal development during which repeated exposure to a stimulus shrinks synapses.

30 May 2013

Study reveals that an epilepsy drug shows promise in preventing noise-induced tinnitus

An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine.

28 May 2013

Neuroscientists identify key circuit elements that contribute to everyday decision in ACC

You are sitting on your couch flipping through TV channels trying to decide whether to stay put or get up for a snack. Such everyday decisions about whether to "stay" or to "go" are supported by a brain region called the anterior cingulate cortex (ACC), which is part of the prefrontal cortex.

27 May 2013

EGFR gums up cell's miRNA-processing machinery under oxygen starvation conditions

Even while being dragged to its destruction inside a cell, a cancer-promoting growth factor receptor fires away, sending signals that thwart the development of tumor-suppressing microRNAs before it's dissolved, researchers reported in an early online publication at Nature.

24 May 2013

Caltech biologists show that microRNA-146a protects stem cells during inflammation

When infections occur in the body, stem cells in the blood often jump into action by multiplying and differentiating into mature immune cells that can fight off illness. But repeated infections and inflammation can deplete these cell populations, potentially leading to the development of serious blood conditions such as cancer.

22 May 2013

Researchers develop new mouse model to discover gene pathways that drive MPNST

University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral nerve sheath tumors that allow them to discover new genes and gene pathways driving this type of cancer.

21 May 2013

Alnylam reports pre-clinical data from ALN-AS1 program for treatment of AIP

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented key pre-clinical proof-of-concept data from its RNAi therapeutic program targeting aminolevulinate synthase-1 (ALAS-1) for the treatment of porphyria including acute intermittent porphyria.

18 May 2013

UC Davis scientists detect novel molecular target for multiple sclerosis

Working with lab mice models of multiple sclerosis, UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved medications against MS.

17 May 2013

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans.

10 May 2013

Mouse Model News and Research

OncoSec Medical signs Sponsored Research Agreement with ODU for melanoma study

Scientists find that mice develop age-related progressive motor symptoms of Parkinson's disease

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

Optogenetics: A promising technique for treatment of obsessive-compulsive disorders

Liver regeneration using cell therapy may be possible, study suggests

Discovery of impaired molecular pathway may help treat children with leukemia

Medicago reports positive interim results from preclinical trial for H7 VLP vaccine candidate

UCLA researchers identify abnormal brain networks in Fragile X syndrome

Researchers establish link between abnormal structure of synapses and behavioral abnormalities of brain circuits in FXS

Growth factor helps hair follicles regenerate during wound healing process, say researchers

Researchers show interleukin-22 guards against bacterial superinfections that can arise after influenza

Findings could lead to better understanding of learning and memory

Study reveals that an epilepsy drug shows promise in preventing noise-induced tinnitus

Neuroscientists identify key circuit elements that contribute to everyday decision in ACC

EGFR gums up cell's miRNA-processing machinery under oxygen starvation conditions

Caltech biologists show that microRNA-146a protects stem cells during inflammation

Researchers develop new mouse model to discover gene pathways that drive MPNST

Alnylam reports pre-clinical data from ALN-AS1 program for treatment of AIP

UC Davis scientists detect novel molecular target for multiple sclerosis

Newly engineered biomaterials could lead to possible cure for Type 1 diabetes, find researchers

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