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Drug compounds target multiple pathways associated with myotonic dystrophy type 1

Efforts to treat myotonic dystrophy type 1, the most common form of muscular dystrophy, are in their infancy. In a new study, researchers report they have added new capabilities to an experimental drug agent that previously defeated only one of DM1's many modes of action. Their retooled compounds interrupt the disease's pathology in three ways.

10 Nov 2015

Paratek initiates Omadacycline phase 3 clinical study in community acquired bacterial pneumonia (CABP)

Paratek Pharmaceuticals, Inc. has announced the dosing of the first patient in its Phase 3 clinical study of its lead drug candidate, omadacycline, for the treatment of Community Acquired Bacterial Pneumonia (CABP). This global Phase 3 study will assess the efficacy and safety of omadacycline compared with moxifloxacin in subjects with CABP.

9 Nov 2015

Vanderbilt wins NIA grant to study effectiveness of nicotine patch in improving memory loss in older adults with MCI

Vanderbilt University Medical Center has received a $9.4 million grant from the National Institute on Aging to test the effectiveness of a transdermal nicotine patch in improving memory loss in older adults with mild cognitive impairment (MCI), a precursor to Alzheimer's disease.

6 Nov 2015

UCSF scientists identify eye drop chemical that may reverse cataracts

A chemical that could potentially be used in eye drops to reverse cataracts, the leading cause of blindness, has been identified by a team of scientists from UC San Francisco (UCSF), the University of Michigan (U-M), and Washington University in St. Louis (WUSTL).

6 Nov 2015

New treatment may help patients with chronic renovascular disease

A new treatment may help patients with a chronic kidney condition that can also lead to heart problems and premature death, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

6 Nov 2015

RXi Pharmaceuticals begins Phase 1/2 clinical trial in ophthalmology

RXi Pharmaceuticals Corporation a biotechnology company focused on discovering and developing innovative therapies primarily in the areas of dermatology and ophthalmology today announced the initiation of a Phase 1/2 clinical trial in ophthalmology. The clinical study RXI-109-1501 will evaluate the safety and clinical activity of RXI-109 to prevent the progression of retinal scarring, a harmful component of numerous retinal diseases.

5 Nov 2015

GHIT Fund invests $10.7 million to fight malaria, TB, leishmaniasis and dengue

The Global Health Innovative Technology Fund, which in the last two years has invested US$43 million to develop innovative tools for fighting diseases worldwide, today announced it is investing $10.7 million at multiple points in the product development pipeline to seek new interventions for malaria, tuberculosis (TB), leishmaniasis and dengue.

5 Nov 2015

$Viking begins VK5211 Phase 2 trial in patients recovering from hip fracture$

Viking begins VK5211 Phase 2 trial in patients recovering from hip fracture

Viking Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on the development of novel, first-in-class or best-in-class therapies for metabolic and endocrine disorders, today announced the initiation of dosing in the company's Phase 2 clinical trial of VK5211 in patients who recently suffered a hip fracture.

3 Nov 2015

Researchers develop biochemical trick that can extend lifespan of peptides

Researchers at University of the Pacific have developed a biochemical trick that can significantly extend the lifespan of peptides, smaller cousins of proteins. The finding opens up new possibilities for creating peptides to treat cancer, infertility and other conditions.

3 Nov 2015

Findings support higher dietary requirements of vitamin E for obese people with metabolic syndrome

A recent study suggests that obese people with metabolic syndrome face an unexpected quandary when it comes to vitamin E - they need more than normal levels of the vitamin because their weight and other problems are causing increased oxidative stress, but those same problems actually cause their effective use of vitamin E to be reduced.

3 Nov 2015

Using smart phone to detect diabetes marker in saliva

With the participation of Mexican and international experts, the device will present immediate results and will be used for diagnosis within low-income populations.

31 Oct 2015

Researchers develop more accurate method of imprinting proteins

It will be increasingly difficult for protein molecules to remain anonymous, and increasingly easy for doctors and patients to detect the early stages of latent diseases. Researchers at the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw and the University of North Texas in Denton have perfected a method of producing thin detecting films that are able to recognize specific proteins.

31 Oct 2015

Rotation model provides explanation of ligand activation mechanism of dimeric receptors

"This 'rotation model', which made the cover of BioEssays, represents a true paradigm shift in the membrane receptor field," stated Prof. Pierre De Meyts, a renowned researcher of insulin and receptor binding for almost half a century and one of the reviewers of the paper by Prof. Ichiro Maruyama, the head of the Information Processing Biology Unit at Okinawa Institute of Science and Technology Graduate University.

31 Oct 2015

Halozyme Therapeutics announces initiation of rivipansel Phase 1 clinical trial

Halozyme Therapeutics, Inc. today announced that the first healthy subject has been dosed in a Phase 1 clinical trial evaluating the safety, tolerability and pharmacokinetics of a subcutaneous formulation of rivipansel, a compound discovered by GlycoMimetics, Inc. and being developed by Pfizer Inc., using Halozyme's ENHANZE formulation.

30 Oct 2015

New single-agent phototherapy system may form valuable new tool to combat cancer

Researchers at Oregon State University today announced an important advance in the field of cancer imaging and phototherapy, using a single-agent system that may ultimately change the efficacy of cancer surgery and treatment around the world.

30 Oct 2015

New technique may enable in-flight detection of hypoxia in pilots

Researchers working in the United States have demonstrated a technique that may enable real-time, in-flight detection of hypoxia in pilots.

29 Oct 2015

Biodegradable polymer could help heal the bones of patients with orthopedic injuries

A plastic derived from cornstarch combined with a volcanic ash compound, Montmorillonite clay, could help heal the bones of hundreds of thousands of patients with orthopedic injuries who need bone replacement after tumor removal, spinal fusion surgery or fracture repair.

28 Oct 2015

Compound News and Research

Drug compounds target multiple pathways associated with myotonic dystrophy type 1

Paratek initiates Omadacycline phase 3 clinical study in community acquired bacterial pneumonia (CABP)

Vanderbilt wins NIA grant to study effectiveness of nicotine patch in improving memory loss in older adults with MCI

UCSF scientists identify eye drop chemical that may reverse cataracts

New treatment may help patients with chronic renovascular disease

RXi Pharmaceuticals begins Phase 1/2 clinical trial in ophthalmology

GHIT Fund invests $10.7 million to fight malaria, TB, leishmaniasis and dengue

Viking begins VK5211 Phase 2 trial in patients recovering from hip fracture

Researchers develop biochemical trick that can extend lifespan of peptides

Findings support higher dietary requirements of vitamin E for obese people with metabolic syndrome

Using smart phone to detect diabetes marker in saliva

Researchers develop more accurate method of imprinting proteins

Rotation model provides explanation of ligand activation mechanism of dimeric receptors

Halozyme Therapeutics announces initiation of rivipansel Phase 1 clinical trial

New single-agent phototherapy system may form valuable new tool to combat cancer

New technique may enable in-flight detection of hypoxia in pilots

Biodegradable polymer could help heal the bones of patients with orthopedic injuries

Scientists find way to produce industrial quantities of beneficial natural compounds in tomatoes

Medlab granted ethics approval to begin human trials using nanotechnology delivery platform

Research shows deep-sea bacteria could help neutralize atmospheric greenhouse gases

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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