Mouse Model News and Research

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Ottawa researchers say advanced mathematical modeling can be used to fight against cancer

Here's a good reason to pay attention in math class. Nature Communications has published a paper from Ottawa researchers today, outlining how advanced mathematical modelling can be used in the fight against cancer.

14 Jun 2013

CSHL scientists solve the mystery of why some infants born with grave syndrome

By identifying a protein that acts as a genetic modifier, scientists at Cold Spring Harbor Laboratory have solved the mystery of why some infants are born with a grave syndrome consisting of cleft palate and major deformities of the skin and limbs, while other infants bearing the same predisposing genetic mutation bear little or no sign of the illness, called EEC.

14 Jun 2013

Penn Medicine researchers identify key molecular player in recurrent breast cancer

According to the American Cancer Society, nearly 40,000 women in the United States will succumb to breast cancer this year. Most of these women will die not from the primary tumor but rather tumor recurrence - the reappearance of the disease following treatment.

14 Jun 2013

HEXIM1 gene makes heart healthier, suppresses breast cancer metastasis

Researchers at Case Western Reserve University have found that a single gene poses a double threat to disease: Not only does it inhibit the growth and spread of breast tumors, but it also makes hearts healthier.

14 Jun 2013

Columbia psychiatry researchers suggest possible approaches to treat or prevent OCD

Columbia Psychiatry researchers have identified what they think may be a mechanism underlying the development of compulsive behaviors. The finding suggests possible approaches to treating or preventing certain characteristics of OCD.

11 Jun 2013

Brain circuits involved in compulsive behavior reveal a surprising connection with obesity

What started as an experiment to probe brain circuits involved in compulsive behavior has revealed a surprising connection with obesity.

11 Jun 2013

OncoSec Medical signs Sponsored Research Agreement with ODU for melanoma study

OncoSec Medical Inc., a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumors, signed a Sponsored Research Agreement with Old Dominion University and the Frank Reidy Research Center for Bioelectrics.

11 Jun 2013

Scientists find that mice develop age-related progressive motor symptoms of Parkinson's disease

The presence of Lewy bodies in nerve cells, formed by intracellular deposits of the protein α-synuclein, is a characteristic pathologic feature of Parkinson's Disease (PD). In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α-synuclein.

10 Jun 2013

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

A drug used to control Type II diabetes can help repair the spinal cords of mice suffering from the inherited disease adrenoleukodystrophy which, untreated, leads eventually to a paralysis, a vegetative state and death.

10 Jun 2013

Optogenetics: A promising technique for treatment of obsessive-compulsive disorders

By applying light stimulation to highly specific neurons in the brain, the researchers managed to re-establish normal behaviour in mice that had beforehand presented pathological repetitive behaviour similar to that observed in human patients suffering from obsessive-compulsive disorders.

10 Jun 2013

Liver regeneration using cell therapy may be possible, study suggests

Liver transplantation is the mainstay of treatment for patients with end-stage liver disease, the 12th leading cause of death in the United States, but new research from the Icahn School of Medicine at Mount Sinai, published in the online journal Cell Stem Cell today, suggests that it may one day become possible to regenerate a liver using cell therapy in patients with liver disease.

10 Jun 2013

Discovery of impaired molecular pathway may help treat children with leukemia

Through genetic engineering of laboratory models, researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center have uncovered a vulnerability in the way cancer cells diverge from normal regenerating cells that may help treat children with leukemia as reported in the journal PNAS on June 3, 2013.

7 Jun 2013

Medicago reports positive interim results from preclinical trial for H7 VLP vaccine candidate

Medicago Inc., a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles, today reported positive interim results from a preclinical trial for an H7N9 Avian Influenza VLP vaccine candidate ("H7 vaccine").

6 Jun 2013

UCLA researchers identify abnormal brain networks in Fragile X syndrome

The genetic malady known as Fragile X syndrome is the most common cause of inherited autism and intellectual disability. Brain scientists know the gene defect that causes the syndrome and understand the damage it does in misshaping the brain's synapses - the connections between neurons. But how this abnormal shaping of synapses translates into abnormal behavior is unclear.

5 Jun 2013

Researchers establish link between abnormal structure of synapses and behavioral abnormalities of brain circuits in FXS

Fragile X syndrome (FXS) is a genetic malady that is the most common inherited cause of autism and intellectual disability. Brain scientists know the gene defect that causes FXS, and the damage it does-- misshaping the brain's synapses, the connections between neurons. But how that abnormal shaping of synapses translates to abnormal behavior is unclear.

4 Jun 2013

Growth factor helps hair follicles regenerate during wound healing process, say researchers

Researchers in the Perelman School of Medicine at the University of Pennsylvania have determined the role of a key growth factor, found in skin cells of limited quantities in humans, which helps hair follicles form and regenerate during the wound healing process.

3 Jun 2013

Researchers show interleukin-22 guards against bacterial superinfections that can arise after influenza

Researchers from the Pasteur Institute, Lille, France have shown in a mouse model that interleukin-22 protects against bacterial superinfections that can arise following influenza.

31 May 2013

Findings could lead to better understanding of learning and memory

Students preparing for final exams might want to wait before pulling an all-night cram session - at least as far as their neurons are concerned. Carnegie Mellon University neuroscientists have discovered a new intermediate phase in neuronal development during which repeated exposure to a stimulus shrinks synapses.

30 May 2013

Study reveals that an epilepsy drug shows promise in preventing noise-induced tinnitus

An epilepsy drug shows promise in an animal model at preventing tinnitus from developing after exposure to loud noise, according to a new study by researchers at the University of Pittsburgh School of Medicine.

28 May 2013

Neuroscientists identify key circuit elements that contribute to everyday decision in ACC

You are sitting on your couch flipping through TV channels trying to decide whether to stay put or get up for a snack. Such everyday decisions about whether to "stay" or to "go" are supported by a brain region called the anterior cingulate cortex (ACC), which is part of the prefrontal cortex.

27 May 2013

Mouse Model News and Research

Ottawa researchers say advanced mathematical modeling can be used to fight against cancer

CSHL scientists solve the mystery of why some infants born with grave syndrome

Penn Medicine researchers identify key molecular player in recurrent breast cancer

HEXIM1 gene makes heart healthier, suppresses breast cancer metastasis

Columbia psychiatry researchers suggest possible approaches to treat or prevent OCD

Brain circuits involved in compulsive behavior reveal a surprising connection with obesity

OncoSec Medical signs Sponsored Research Agreement with ODU for melanoma study

Scientists find that mice develop age-related progressive motor symptoms of Parkinson's disease

Drug used to control Type II diabetes can help repair spinal cords of mice suffering from inherited disease

Optogenetics: A promising technique for treatment of obsessive-compulsive disorders

Liver regeneration using cell therapy may be possible, study suggests

Discovery of impaired molecular pathway may help treat children with leukemia

Medicago reports positive interim results from preclinical trial for H7 VLP vaccine candidate

UCLA researchers identify abnormal brain networks in Fragile X syndrome

Researchers establish link between abnormal structure of synapses and behavioral abnormalities of brain circuits in FXS

Growth factor helps hair follicles regenerate during wound healing process, say researchers

Researchers show interleukin-22 guards against bacterial superinfections that can arise after influenza

Findings could lead to better understanding of learning and memory

Study reveals that an epilepsy drug shows promise in preventing noise-induced tinnitus

Neuroscientists identify key circuit elements that contribute to everyday decision in ACC

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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