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Ceritinib ‘highly active’ in advanced ALK-rearranged NSCLC

Phase I study findings suggest the investigational drug ceritinib is effective in patients with advanced non-small-cell lung cancer with anaplastic lymphoma kinase gene rearrangement, even in those who develop resistance to crizotinib.

14 Apr 2014

Two candidate mTOR therapy biomarkers identified in RCC

Two genes, TSC1 and MTOR, warrant further investigation as biomarkers for treatment benefit with rapalogs in patients with renal cell carcinoma, indicate study results published in Clinical Cancer Research.

14 Apr 2014

Researcher at Fox Chase Cancer Center wins a new Cytation™ 3 Cell Imaging Multi-Mode Reader in BioTek's "Think Possible" Application Contest

BioTek congratulates Dr. Jeff Peterson of the Fox Chase Cancer Center in Pennsylvania for winning a new Cytation™ 3 Cell Imaging Multi-Mode Reader in BioTek's "Think Possible" Application Contest. Entrants were judged on a short essay that they submitted, detailing the application that they think is possible for their specific research using the Cytation 3. As an Associate Professor, Dr. Peterson studies chemical biology and kinase signaling in cancer.

14 Apr 2014

Amrubicin regimen inferior to irinotecan for extensive SCLC

Irinotecan plus cisplatin remains the gold standard for Japanese patients with extensive small-cell lung cancer, say researchers, after amrubicin plus cisplatin failed to improve survival in their randomised phase III trial.

11 Apr 2014

1/4 human tumor exist genetic polymorphisms linked with increased risk of cancer

In 10% of human tumors there is a family history of hereditary disease associated with mutations in identified genes. The best examples are the cases of polyps in the large intestine associated with the APC gene and breast cancer associated with BRCA1 and BRCA2 genes.

11 Apr 2014

Researchers discover tumor suppressor gene folliculin essential to normal lung function in BHD patients

Researchers at Penn Medicine have discovered that the tumor suppressor gene folliculin (FLCN) is essential to normal lung function in patients with the rare disease Birt-Hogg-Dube (BHD) syndrome, a genetic disorder that affects the lungs, skin and kidneys.

11 Apr 2014

Adoptive T-cell therapy may help in treating liver cancer, says study

Significant new data presented today at the International Liver Congress- 2014 indicate that liver cancer (Hepatocellular Carcinoma (HCC)) may be treated by adoptive T-cell therapy.

11 Apr 2014

Scientists report first human recipients of laboratory-grown vaginal organs

Scientists reported today the first human recipients of laboratory-grown vaginal organs. A research team led by Anthony Atala, M.D., director of Wake Forest Baptist Medical Center's Institute for Regenerative Medicine, describes in the Lancet long-term success in four teenage girls who received vaginal organs that were engineered with their own cells.

11 Apr 2014

Findings pave way for potential therapy to combat H1N1 flu virus

Flu epidemics cause up to half a million deaths worldwide each year, and emerging strains continually threaten to spread to humans and cause even deadlier pandemics. A study by McGill University professor Maziar Divangahi published by Cell Press on April 10 in the journal Immunity reveals that a drug that inhibits a molecule called prostaglandin E2 (PGE2) increases survival rates in mice infected with a lethal dose of the H1N1 flu virus.

11 Apr 2014

Targeting enzyme responsible for glucose metabolism halts tumor growth, say researchers

Cancer cells generate energy differently than normal cells, a characteristic that helps them to survive and metastasize. A major goal in the field of cancer metabolism is to find ways to overcome this survival advantage.

11 Apr 2014

Researchers show development of new cell models that track, report clock gene function

The consequences of modern life -- shift work, cell phone addiction, and travel across time zones -- all disturb internal clocks. These are found in the brain where they regulate sleep and throughout the body where they regulate physiology and metabolism.

11 Apr 2014

Scientists discover protein potentially good target for influenza A virus

Scientists at The University of Texas at Austin have discovered that a protein produced by the influenza A virus helps it outwit one of our body's natural defense mechanisms. That makes the protein a potentially good target for antiviral drugs directed against the influenza A virus.

11 Apr 2014

Researchers develop novel assay to identify genes controlling pharynx regeneration in flatworms

As multicellular creatures go, planaria worms are hardly glamorous. To say they appear rudimentary is more like it. These tiny aquatic flatworms that troll ponds and standing water resemble brown tubes equipped with just the basics: a pair of beady light-sensing "eyespots" on their head and a feeding tube called the pharynx (which doubles as the excretory tract) that protrudes from a belly sac to suck up food.

11 Apr 2014

Researchers to develop cell-based approaches to minimize scarring in adult wounds

In early fetal development, skin wounds undergo regeneration and healing without scar formation. This mechanism of wound healing later disappears, but by studying the fetal stem cells capable of this scarless wound healing, researchers may be able to apply these mechanisms to develop cell-based approaches able to minimize scarring in adult wounds, as described in a Critical Review article published in Advances in Wound Care, a monthly publication from Mary Ann Liebert, Inc., publishers and an Official Journal of the Wound Healing Society.

11 Apr 2014

Research team to investigate ways to develop novel immune therapies for HPV-associated cancers

Stand Up To Cancer and the Farrah Fawcett Foundation, along with the American Association for Cancer Research, SU2C's Scientific Partner, announced the formation of a research team dedicated to HPV-related cancers during a press event today at the AACR Annual Meeting 2014, held here April 5-9.

11 Apr 2014

Scientists identify enzyme that could be a useful target in treating asthma, cancer

In experiments with mice, Johns Hopkins Kimmel Cancer Center scientists have identified an enzyme involved in the regulation of immune system T cells that could be a useful target in treating asthma and boosting the effects of certain cancer therapies.

11 Apr 2014

Tumor-suppressing protein acts as dimmer switch to dial down gene expression

A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014.

11 Apr 2014

Scientists solve a decades-long mystery of cell biology

A team led by scientists at The Scripps Research Institute has identified a long-sought protein that facilitates one of the most basic functions of cells: regulating their volume to keep from swelling excessively.

11 Apr 2014

Researchers identify biological process that appears to trigger Parkinson's disease

Working with human neurons and fruit flies, researchers at Johns Hopkins have identified and then shut down a biological process that appears to trigger a particular form of Parkinson's disease present in a large number of patients. A report on the study, in the April 10 issue of the journal Cell, could lead to new treatments for this disorder.

11 Apr 2014

Acupuncture protects brain neurons against injury in rats following heroin relapse

Heroin abuse can damage many brain areas, including the pedunculopontine tegmental nucleus of the midbrain, the ventral tegmental area, and nucleus accumbens. Persistent use of heroin induced irreversible damage to the nervous system.

11 Apr 2014

B Cell News and Research

Ceritinib ‘highly active’ in advanced ALK-rearranged NSCLC

Two candidate mTOR therapy biomarkers identified in RCC

Researcher at Fox Chase Cancer Center wins a new Cytation™ 3 Cell Imaging Multi-Mode Reader in BioTek's "Think Possible" Application Contest

Amrubicin regimen inferior to irinotecan for extensive SCLC

1/4 human tumor exist genetic polymorphisms linked with increased risk of cancer

Researchers discover tumor suppressor gene folliculin essential to normal lung function in BHD patients

Adoptive T-cell therapy may help in treating liver cancer, says study

Scientists report first human recipients of laboratory-grown vaginal organs

Findings pave way for potential therapy to combat H1N1 flu virus

Targeting enzyme responsible for glucose metabolism halts tumor growth, say researchers

Researchers show development of new cell models that track, report clock gene function

Scientists discover protein potentially good target for influenza A virus

Researchers develop novel assay to identify genes controlling pharynx regeneration in flatworms

Researchers to develop cell-based approaches to minimize scarring in adult wounds

Research team to investigate ways to develop novel immune therapies for HPV-associated cancers

Scientists identify enzyme that could be a useful target in treating asthma, cancer

Tumor-suppressing protein acts as dimmer switch to dial down gene expression

Scientists solve a decades-long mystery of cell biology

Researchers identify biological process that appears to trigger Parkinson's disease

Acupuncture protects brain neurons against injury in rats following heroin relapse

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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