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Researchers generate 3D model of human malaria parasite genome

A research team led by a cell biologist at the University of California, Riverside has generated a 3D model of the human malaria parasite genome at three different stages in the parasite's life cycle - the first time such 3D architecture has been generated during the progression of the life cycle of a parasite.

7 Apr 2014

UH Math collaborates with Rice on synthetic gene circuit

A long-standing challenge in synthetic biology has been to create gene circuits that behave in predictable and robust ways. Mathematical modeling experts from the University of Houston (UH) collaborated with experimental biologists at Rice University to create a synthetic genetic clock that keeps accurate time across a range of temperatures.

7 Apr 2014

BioTek’s MultiFlo™ FX now available with Random Access Dispense technology

BioTek’s MultiFlo™ FX is now available with optional RAD™ (Random Access Dispense) technology to further extend its application range and flexibility. RAD technology offers single-channel dispensing to random individual microplate wells along with rapid reagent dispensing into large volume wells of 6- to 24- well microplates. MultiFlo FX can also be separately configured with an optional wash module for 6- to 384-well plates.

4 Apr 2014

Too little or too much of SRPK1 enzyme promotes cancer, shows research

Researchers at the University of California, San Diego School of Medicine have found that too little or too much of an enzyme called SRPK1 promotes cancer by disrupting a regulatory event critical for many fundamental cellular processes, including proliferation.

4 Apr 2014

Novartis to present early stage data on 19 investigational compounds at AACR annual meeting

Novartis announced today that early stage data on 19 investigational compounds in its oncology pipeline will be presented at the annual meeting of the American Association of Cancer Research, April 5-9, 2014 in San Diego, CA.

4 Apr 2014

Magnetically controlled nanoparticles force tumour cells to 'self-destruct', shows research

Using magnetically controlled nanoparticles to force tumour cells to 'self-destruct' sounds like science fiction, but could be a future part of cancer treatment, according to research from Lund University in Sweden.

4 Apr 2014

Alteration in tumor suppressor gene TP53 plays key role early in development of bone cancer

The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project found mutations in the tumor suppressor gene TP53 in 90 percent of osteosarcomas, suggesting the alteration plays a key role early in development of the bone cancer.

4 Apr 2014

Walking reduces high risk for heart disease in patients with kidney infection

Heart disease and infection are major complications and the leading causes of death in patients with chronic kidney disease. It is now well established that immune system dysfunction is involved in both of these pathological processes.

4 Apr 2014

Inhibiting cancer-promoting prolactin causes unconventional cell death in preclinical research

Under stress from chemotherapy or radiation, some cancer cells dodge death by consuming a bit of themselves, allowing them to essentially sleep through treatment and later awaken as tougher, resistant disease.

4 Apr 2014

DFG German Research Foundation to establish 16 new Priority Programs

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) will establish 16 new Priority Programmes, in which researchers will investigate fundamental scientific questions in particularly topical or emerging areas of research over the next few years.

4 Apr 2014

Researcher pinpoints error in protein formation that could be root of amyotrophic lateral sclerosis

By studying nerve cells that originated in patients with a severe neurological disease, a University of Wisconsin-Madison researcher has pinpointed an error in protein formation that could be the root of amyotrophic lateral sclerosis.

4 Apr 2014

Harvard stem cell scientists discover potential treatment for amyotrophic lateral sclerosis

Harvard stem cell scientists have discovered that a recently approved medication for epilepsy may possibly be a meaningful treatment for amyotrophic lateral sclerosis (ALS)-Lou Gehrig's disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital to design an initial clinical trial testing the safety of the treatment in ALS patients.

4 Apr 2014

Chordoma Foundation grants $75,000 to support development of new mouse model for bone cancer research

The Chordoma Foundation has made a seed grant of $75,000 to Adrienne Flanagan, M.D., Ph.D., of University College, London, and her Jackson Laboratory collaborator, Mike Sasner, Ph.D., to develop a new mouse model for chordoma, a difficult-to-treat bone cancer affecting the skull and spine.

3 Apr 2014

FDA clears Omeros' OMS721 IND for inhibition of complement‑mediated TMAs

Omeros Corporation today announced that its Investigational New Drug Application (IND) to evaluate OMS721 for the inhibition of complement‑mediated thrombotic microangiopathies (TMAs) has been cleared by the U.S. Food and Drug Administration.

3 Apr 2014

CardioCell receives IND approval for Phase IIa clinical study of itMSC therapy to treat heart failure

CardioCell LLC has just received the FDA's investigational new drug (IND) approval for a United States-based, Phase IIa clinical study using its allogeneic stem-cell therapy to treat subjects with chronic heart failure (CHF), which generates more than 1 million hospitalizations annually.

3 Apr 2014

Stowers team reports genome-wide analysis of genes that drive cell division in multicellular organism

In textbooks, the grand-finale of cell division is the tug-of-war fought inside dividing cells as duplicated pairs of chromosomes get dragged in opposite directions into daughter cells.

3 Apr 2014

Findings may help develop targeted drugs to fight cancer, neurodegenerative diseases

The molecular details of how zinc, an essential trace element of human metabolism, interacts with the enzyme caspase-3, which is central to apoptosis or cell death, have been elucidated in a new study led by researchers at Virginia Commonwealth University. The study is featured on the cover of the April issue of the journal Angewandte Chemie's International Edition.

3 Apr 2014

Researchers generate high-resolution blueprint for how to build human brain

Researchers at the Allen Institute for Brain Science have generated a high-resolution blueprint for how to build a human brain, with a detailed map of where different genes are turned on and off during mid-pregnancy at unprecedented anatomical resolution.

3 Apr 2014

Scientists identify new biomarker linked to non-small cell lung cancer, head and neck cancers

A team led by a scientist from the Florida campus of The Scripps Research Institute has identified a new biomarker linked to better outcomes of patients with head and neck cancers and non-small cell lung cancer. The work could help scientists develop new diagnostics and therapies and help physicians determine the best long-term treatments for patients with these cancers.

3 Apr 2014

Researchers investigate how gene regulation affects evolution and development

Johannes Gutenberg University Mainz (JGU) has received EUR 900,000 for three years to investigate, jointly with the Institute of Molecular Biology (IMB), how gene regulation affects evolution and development.

3 Apr 2014

B Cell News and Research

Researchers generate 3D model of human malaria parasite genome

UH Math collaborates with Rice on synthetic gene circuit

BioTek’s MultiFlo™ FX now available with Random Access Dispense technology

Too little or too much of SRPK1 enzyme promotes cancer, shows research

Novartis to present early stage data on 19 investigational compounds at AACR annual meeting

Magnetically controlled nanoparticles force tumour cells to 'self-destruct', shows research

Alteration in tumor suppressor gene TP53 plays key role early in development of bone cancer

Walking reduces high risk for heart disease in patients with kidney infection

Inhibiting cancer-promoting prolactin causes unconventional cell death in preclinical research

DFG German Research Foundation to establish 16 new Priority Programs

Researcher pinpoints error in protein formation that could be root of amyotrophic lateral sclerosis

Harvard stem cell scientists discover potential treatment for amyotrophic lateral sclerosis

Chordoma Foundation grants $75,000 to support development of new mouse model for bone cancer research

FDA clears Omeros' OMS721 IND for inhibition of complement‑mediated TMAs

CardioCell receives IND approval for Phase IIa clinical study of itMSC therapy to treat heart failure

Stowers team reports genome-wide analysis of genes that drive cell division in multicellular organism

Findings may help develop targeted drugs to fight cancer, neurodegenerative diseases

Researchers generate high-resolution blueprint for how to build human brain

Scientists identify new biomarker linked to non-small cell lung cancer, head and neck cancers

Researchers investigate how gene regulation affects evolution and development

Immunology eBook

Evaluating new approaches for rare disease genomics

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