Cell News and Research

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Pabetalone (RVX-208) to be tested in proof-of-concept pilot study in complement mediated diseases

Resverlogix Corp. announced today the commencement of an Orphan Disease Program specific for Complement Mediated Diseases. New data generated by Resverlogix has demonstrated that BET inhibition by apabetalone (RVX-208) has effects on multiple biological pathways that underlie disease pathology.

24 Sep 2015

New technique allows scientists to see blood-forming stem cells present in the bone marrow

A team of scientists at the Children's Research Institute at UT Southwestern has become the first to use a tissue-clearing technique to localize a rare stem cell population, in the process cracking open a black box containing detailed information about where blood-forming stem cells are located and how they are maintained.

24 Sep 2015

Hyperbaric oxygen therapy improves outcomes of umbilical cord blood transplant patients

For the past 27 years, cord blood transplants have been a life-saving treatment option for thousands of people with leukemia, non-Hodgkins lymphoma, Hodgkins disease and myelodysplastic disorders. Cord blood helps replace cancerous blood cells and replenish a patient's own bone marrow and immune system. Even with its success, researchers are continually looking for ways to improve the transplant process and increase cure rates.

24 Sep 2015

City of Hope receives gift to open new Judy and Bernard Briskin Center for Multiple Myeloma Research

The Judy and Bernard Briskin Family Foundation has announced a gift to launch the new Judy and Bernard Briskin Center for Multiple Myeloma Research at City of Hope, the third named center within City of Hope's new Hematologic Malignancies and Stem Cell Transplantation Institute. The generous gift will enable the institution to further its already considerable accomplishments in the field of myeloma treatment and research.

24 Sep 2015

Discovery opens door to more targeted, effective treatments for cancer

In a discovery that could lead to more targeted and effective treatments for certain lung and prostate cancers, researchers at the University of Virginia School of Medicine have identified two new cancer-causing gene mutations - mutations that may be particularly susceptible to cancer-fighting drugs already approved by the federal Food and Drug Administration. One of the gene mutations also may play a key role in early menopause.

24 Sep 2015

Research suggests potential drug targets to stop cancer spread

It only takes seconds: one cancerous cell breaks off from a tumor, slips into the bloodstream and quickly lodges elsewhere in the body. These colonizers may bloom into deadly metastatic cancer right away or lie dormant for years, only to trigger a recurrence decades after the primary tumor is removed.

24 Sep 2015

Stanford researchers successfully defeat C. difficile bacteria

Stanford University School of Medicine scientists successfully defeated a dangerous intestinal pathogen, Clostridium difficile, with a drug targeting its toxins rather than its life.

24 Sep 2015

WPI awarded NIH grant to design new pharmaceuticals, simplify manufacturing of existing drugs

The National Institutes of Health has awarded $346,000 to Worcester Polytechnic Institute for a three-year research project to advance development of a chemical process that could significantly improve the ability to design new pharmaceuticals and streamline the manufacturing of existing drugs.

24 Sep 2015

Novel approach promises easier way to detect protein fibers implicated in neuro-degenerative diseases

Liquid crystals are familiar to most of us as the somewhat humdrum stuff used to make computer displays and TVs. Even for scientists, it has not been easy to find other ways of using them.

24 Sep 2015

TUM, Stanford University scientists create new cancer therapy concept

Pancreatic cancer is one of the most aggressive forms of cancer and one of the most difficult to treat. Its high resistance to treatment is a major problem, particularly in the advanced stages.

24 Sep 2015

Scientists trace out intricate molecular pathway that may explain tamoxifen resistance in breast cancer patients

For reasons unknown, many patients with breast cancer treated with the estrogen receptor-blocking drug tamoxifen eventually become resistant to the treatment despite the fact that their cancer cells still have the estrogen receptor proteins that the drug normally targets.

24 Sep 2015

Study uses genome- and epigenome-editing tools to determine disease-causing variants

A paper receiving advance online release in Nature Medicine describes a strategy for meeting one of today's most significant challenges in genomic medicine - determining whether a specific DNA variant in the non-protein-coding genome is the actual disease-causing variant of an associated disease risk.

24 Sep 2015

Researchers develop promising metal-based compound to fight kidney cancer

Researchers developed a promising metal-based compound that destroys kidney cancer cells, while leaving normal cells unharmed. The findings may provide a new way of treating kidney cancer, opening the potential for more potent and less toxic therapies that would give cancer patients a better quality of life.

24 Sep 2015

UT Southwestern researchers find a previously unknown genetic code

UT Southwestern physiologists trying to understand the genetic code have found a previously unknown code that helps explain which protein should be created to form a particular type of cell.

24 Sep 2015

NGN3-expressing cells in adult human pancreas offer hope to diabetics

Cells that express neurogenin 3 (NGN3) may one day be harnessed to create a plentiful supply of insulin-producing beta cells for the treatment of diabetes, a study led by researchers at the University of South Florida suggests.

24 Sep 2015

MIT neuroscientists identify brain circuit critical in forming episodic memory

When you remember a particular experience, that memory has three critical elements -- what, when, and where. MIT neuroscientists have now identified a brain circuit that processes the "when" and "where" components of memory.

24 Sep 2015

MIT researchers devise new system to genetically engineer viruses to combat harmful bacteria

In the hunt for new ways to kill harmful bacteria, scientists have turned to a natural predator: viruses that infect bacteria. By tweaking the genomes of these viruses, known as bacteriophages, researchers hope to customize them to target any type of pathogenic bacteria.

23 Sep 2015

S. Lawrence Zipursky to receive 2015 Louisa Gross Horwitz Prize from Columbia University

Columbia University will award the 2015 Louisa Gross Horwitz Prize to S. Lawrence Zipursky, PhD, for discovering a molecular identification system that helps neurons to navigate and wire the brain. Zipursky is a professor of biological chemistry at the University of California, Los Angeles and a Howard Hughes Medical Institute investigator.

23 Sep 2015

OncoGenex reports results from Phase 2 Rainier study in patients with untreated metastatic pancreatic cancer

OncoGenex Pharmaceuticals, Inc. announced today initial results from the Phase 2 Rainier study evaluating apatorsen in combination with ABRAXANE (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) and gemcitabine compared to ABRAXANE and gemcitabine alone in patients with untreated metastatic pancreatic cancer.

23 Sep 2015

Researchers receive NIH grants to find genomic regions containing variants that affect disease risk

Six new grants from the National Institutes of Health will support researchers to develop new computational approaches for searching among millions of genomic variants to find those that make a difference in disease susceptibility or in other traits.

23 Sep 2015

Cell News and Research

Pabetalone (RVX-208) to be tested in proof-of-concept pilot study in complement mediated diseases

New technique allows scientists to see blood-forming stem cells present in the bone marrow

Hyperbaric oxygen therapy improves outcomes of umbilical cord blood transplant patients

City of Hope receives gift to open new Judy and Bernard Briskin Center for Multiple Myeloma Research

Discovery opens door to more targeted, effective treatments for cancer

Research suggests potential drug targets to stop cancer spread

Stanford researchers successfully defeat C. difficile bacteria

WPI awarded NIH grant to design new pharmaceuticals, simplify manufacturing of existing drugs

Novel approach promises easier way to detect protein fibers implicated in neuro-degenerative diseases

TUM, Stanford University scientists create new cancer therapy concept

Scientists trace out intricate molecular pathway that may explain tamoxifen resistance in breast cancer patients

Study uses genome- and epigenome-editing tools to determine disease-causing variants

Researchers develop promising metal-based compound to fight kidney cancer

UT Southwestern researchers find a previously unknown genetic code

NGN3-expressing cells in adult human pancreas offer hope to diabetics

MIT neuroscientists identify brain circuit critical in forming episodic memory

MIT researchers devise new system to genetically engineer viruses to combat harmful bacteria

S. Lawrence Zipursky to receive 2015 Louisa Gross Horwitz Prize from Columbia University

OncoGenex reports results from Phase 2 Rainier study in patients with untreated metastatic pancreatic cancer

Researchers receive NIH grants to find genomic regions containing variants that affect disease risk

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