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FDA approves KALYDECO for people with cystic fibrosis

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced the U.S. Food and Drug Administration (FDA) approved a supplemental New Drug Application (sNDA) for KALYDECOTM (ivacaftor) for people with cystic fibrosis (CF) ages 6 and older who have one of eight additional mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. KALYDECO was first approved in January 2012 for people with CF ages 6 and older who have at least one copy of the G551D mutation.

26 Feb 2014

Fred Hutchinson, SCCA researchers receive Seattle Business Magazine's 2014 Leaders in Health Care Awards

Researchers at Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance (SCCA) were recognized in several categories of Seattle Business Magazine's 2014 Leaders in Health Care Awards, including the publication's Lifetime Achievement Award, given to Frederick R. Appelbaum, M.D., executive vice president and deputy director of Fred Hutch and president of SCCA.

26 Feb 2014

Scales of zebrafish suitable for identifying new drugs for treating bone diseases

The scales of the zebrafish are very suitable for identifying potential new drugs for treating bone diseases. This is good news because it means fewer mice and rats will be needed for that work.

26 Feb 2014

Biothera’s Phase 2b clinical trial in NSCLC presented at International Association for the Study of Lung Cancer

Biothera presented results of its Phase 2b clinical trial in non-small cell lung cancer (NSCLC) this past weekend to top clinicians and scientists at the invitation-only International Association for the Study of Lung Cancer meeting on targeted therapies in Santa Monica, CA.

26 Feb 2014

New optical device may help docs to diagnose blood coagulation status in near real time

Defective blood coagulation is one of the leading causes of preventable death in patients who have suffered trauma or undergone surgery. The body's natural defense against severe blood loss is the clotting process, in which platelets, plasma proteins, and other blood components interact to form a sticky, mesh-like structure.

26 Feb 2014

Study identifies enzyme with key role in precancerous lesions

Cancer of the pancreas is usually not detected until it's too late to cure. But precursor lesions that form in the pancreas and its ducts can signal the disease before it strikes, and when caught early enough, they can be prevented from progressing to become cancer.

26 Feb 2014

Increased brain cell activity boosts protein linked to Alzheimer's disease

Increased brain cell activity boosts brain fluid levels of a protein linked to Alzheimer's disease, according to new research from scientists at Washington University School of Medicine in St. Louis.

26 Feb 2014

Johns Hopkins researchers use tiny particles to train immune systems of mice to fight melanoma

Using tiny particles designed to target cancer-fighting immune cells, Johns Hopkins researchers have trained the immune systems of mice to fight melanoma, a deadly skin cancer. The experiments, described tk on the website of ACS Nano, represent a significant step toward using nanoparticles and magnetism to treat a variety of conditions, the researchers say.

26 Feb 2014

Researcher isolates gene thought to play role in development of Alzheimer's disease

A team of international scientists, including a researcher from Simon Fraser University, has isolated a gene thought to play a causal role in the development of Alzheimer's disease. The Proceedings of the National Academy of Sciences recently published the team's study.

26 Feb 2014

Researcher identifies ''conductor'' in development of muscle tissue

A team led by Jean-Fran-ois C-t-, researcher at the IRCM, identified a ''conductor'' in the development of muscle tissue. The discovery, published online yesterday by the scientific journal Proceedings of the National Academy of Sciences (PNAS), could have an important impact on the treatment of muscular diseases such as myopathies and muscular dystrophies.

26 Feb 2014

Unusual EGFR mutation should influence advanced NSCLC treatment choice

Non-small-cell lung cancer patients with very unusual epidermal growth factor receptor mutations may be more likely to be benefit from first-line chemotherapy than a tyrosine kinase inhibitor, research suggests.

25 Feb 2014

Partial nephrectomy may offer younger renal cancer patients survival advantage

Partial nephrectomy may offer younger patients with localized renal cancer a distinct survival advantage compared with the complete removal of the kidney, US research suggests.

25 Feb 2014

Perioperative blood transfusion worsens kidney cancer patients’ survival

Patients who receive blood transfusions around the time of their surgery for nonmetastatic renal cell carcinoma have a worse chance of survival than those who do not, results of a large US study suggest.

25 Feb 2014

Researchers produce extremely accurate and detailed images of "toxic injections"

Bacteria have developed many different ways of smuggling their toxic cargo into cells. Tripartite Tc toxin complexes, which are used by bacteria like the plague pathogen Yersinia pestis and the insect pathogen Photorhabdus luminescens, are particularly unusual.

25 Feb 2014

FamilyCord provides direct cord blood and cord tissue services to Venezuelan families

FamilyCord, a subsidiary of California Cryobank, now provides direct cord blood and cord tissue services to Venezuelan families and has assumed management of clients of Cordon de Vida, one of Venezuela's largest cord blood banks.

25 Feb 2014

Study: Routine testing with FISH and IHC may enhance detection of ALK-positive NSCLC

The findings of a recent study indicate that routine testing with both fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) may enhance the detection of ALK-positive non-small cell lung cancer (NSCLC).

25 Feb 2014

Opiate use alters activity of specific protein needed for normal functioning of brain's reward center

Identifying the specific pathways that promote opioid addiction, pain relief, and tolerance are crucial for developing more effective and less dangerous analgesics, as well as developing new treatments for addiction.

25 Feb 2014

Researchers develop novel technique for detecting ALK rearrangements in non-small cell lung cancers

Researchers have developed a novel technique for detecting ALK rearrangements in non-small cell lung cancers (NSCLCs) that is more sensitive and easier to perform than currently available techniques.

25 Feb 2014

Researchers discover how brain cells change during learning and memories

A new University of British Columbia study identifies an important molecular change that occurs in the brain when we learn and remember.

25 Feb 2014

UCLA scientists developed experimental treatment that eradicates acute type of leukemia in mice

A diverse team of scientists from UCLA's Jonsson Comprehensive Cancer Center have developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.

25 Feb 2014

B Cell News and Research

FDA approves KALYDECO for people with cystic fibrosis

Fred Hutchinson, SCCA researchers receive Seattle Business Magazine's 2014 Leaders in Health Care Awards

Scales of zebrafish suitable for identifying new drugs for treating bone diseases

Biothera’s Phase 2b clinical trial in NSCLC presented at International Association for the Study of Lung Cancer

New optical device may help docs to diagnose blood coagulation status in near real time

Study identifies enzyme with key role in precancerous lesions

Increased brain cell activity boosts protein linked to Alzheimer's disease

Johns Hopkins researchers use tiny particles to train immune systems of mice to fight melanoma

Researcher isolates gene thought to play role in development of Alzheimer's disease

Researcher identifies ''conductor'' in development of muscle tissue

Unusual EGFR mutation should influence advanced NSCLC treatment choice

Partial nephrectomy may offer younger renal cancer patients survival advantage

Perioperative blood transfusion worsens kidney cancer patients’ survival

Researchers produce extremely accurate and detailed images of "toxic injections"

FamilyCord provides direct cord blood and cord tissue services to Venezuelan families

Study: Routine testing with FISH and IHC may enhance detection of ALK-positive NSCLC

Opiate use alters activity of specific protein needed for normal functioning of brain's reward center

Researchers develop novel technique for detecting ALK rearrangements in non-small cell lung cancers

Researchers discover how brain cells change during learning and memories

UCLA scientists developed experimental treatment that eradicates acute type of leukemia in mice

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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