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Scientists reexamine gene strongly linked to Alzheimer's disease

Scientists' picture of how a gene strongly linked to Alzheimer's disease harms the brain may have to be revised, researchers at Washington University School of Medicine in St. Louis have found. People with harmful forms of the APOE gene have up to 12 times the risk of developing Alzheimer's disease compared with those who have other variations of the gene.

8 May 2013

New therapeutic targets for reducing heart disease in people with type 1 diabetes

Type 1 (insulin-dependent) diabetes appears to increase the risk of heart disease, the leading cause of death among people with high blood sugar, partly by stimulating the production of calprotectin, a protein that sparks an inflammatory process that fuels the buildup of artery-clogging plaque.

8 May 2013

Seven-year quest to understand how breast cancer cells resist treatment

A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death.

8 May 2013

HSPH researchers discover potential target to treat type 2 diabetes and other metabolic diseases

Harvard School of Public Health (HSPH) researchers have discovered that a particular type of protein (hormone) found in fat cells helps regulate how glucose (blood sugar) is controlled and metabolized (used for energy) in the liver.

8 May 2013

Scientists identify TR4 protein that drives the formation of pituitary tumors in Cushing's disease

Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this potentially life-threatening disorder.

8 May 2013

Vanderbilt raises awareness of dangers associated with distracted driving

Vanderbilt University Medical Center is raising awareness of the dangers associated with distracted driving through its participation in the newly released video for the song "Highway Don't Care," performed by Tim McGraw and featuring Taylor Swift and Keith Urban.

8 May 2013

IDIBELL signs patent licensing agreement with Minoryx

The Bellvittge Biomedical Research Institute has signed a licensing agreement with the Spanish biotechnology company Minoryx of a patent for the treatment of X-linked adrenoleukodystrophy, a rare serious neurodegenerative disease which has no effective treatment.

8 May 2013

Cell Medica treats first pediatric patient in ASPIRE Trial

Cell Medica today announced the treatment of the first patient in the ASPIRE Trial, an early stage Phase I/II clinical study investigating the safety and efficacy of Cytovir ADV for the treatment of adenovirus infections in immunosuppressed pediatric patients following bone marrow transplantation.

8 May 2013

EPSRC-funded study explores feasibility of using natural fibres for cartilage repair

Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer

8 May 2013

Study shows turning up few microRNAs may offer much anti-breast-cancer activity

A University of Colorado Cancer Center study recently published in the journal Cell Death & Disease shows that turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot - and without the unwanted side effects.

8 May 2013

Testing Stat5 gene amplification in prostate cancer patients could provide powerful therapy: Study

An international group of investigators, led by researchers at Thomas Jefferson University's Kimmel Cancer Center, have solved the mystery of why a substantial percentage of castrate-resistant metastatic prostate cancer cells contain abnormally high levels of the pro-growth protein Stat5.

8 May 2013

Research discovery may lead to effective new treatments for neurodegenerative disease

UCLA researchers led by Drs. Peiyee Lee and Richard Gatti at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have used induced pluripotent stem cells to advance disease-in-a-dish modeling of a rare genetic disorder, Ataxia Telangiectasia.

8 May 2013

Clinical data of cabozantinib to be presented at ASCO meeting

Exelixis, Inc. announced today that cabozantinib will be the subject of nine separate data presentations at the upcoming 2013 Annual Meeting of the American Society of Clinical Oncology.

8 May 2013

Advances in lung cancer treatment have major impact on short- and long-term outcomes

The American College of Chest Physicians third edition of evidence-based lung cancer guidelines, Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, recommends offering low-dose computed tomography scanning for lung cancer screening to people with a significant risk of lung cancer due to age and smoking history.

8 May 2013

New skin cancer drug successfully tested in humans

A new class of drug targeting skin cancer's genetic material has been successfully tested in humans for the first time, opening the way to new treatments for a range of conditions from skin cancers to eye diseases.

8 May 2013

Isis begins clinical study of ISIS-STAT3 in patients with metastatic liver cancer

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 1b/2a clinical study of ISIS-STAT3Rx in patients with advanced metastatic hepatocellular carcinoma (HCC).

7 May 2013

Janssen enrolls patients in expanded access program for mantle cell lymphoma

Janssen Research & Development, LLC (Janssen) today announced patients are now enrolling in a multicenter, open-label expanded access program (EAP) in the United States for the investigational oral Bruton's Tyrosine Kinase (BTK) inhibitor ibrutinib, which is being jointly developed by Janssen and Pharmacyclics, Inc.

7 May 2013

Biomedical engineers grow 3D human heart muscle that acts just like natural tissue

Duke University biomedical engineers have grown three-dimensional human heart muscle that acts just like natural tissue. This advancement could be important in treating heart attack patients or in serving as a platform for testing new heart disease medicines.

7 May 2013

Complex network of molecules controls formation and activity of neuronal connections

Environment moulds behaviour - and not just that of people in society, but also at the microscopic level. This is because, for their function, neurons are dependent on the cell environment, the so-termed extracellular matrix.

7 May 2013

Concordia professor publishes new findings on cross-cultural commonalities associated with suicide

Just over a month ago, a young high school student from Halifax committed suicide after photos of her being raped were posted on the Internet. Her story wasn't just about bullying. It was also about the complex feelings her friends and family faced with her decision to take her own life.

7 May 2013

Cell News and Research

Scientists reexamine gene strongly linked to Alzheimer's disease

New therapeutic targets for reducing heart disease in people with type 1 diabetes

Seven-year quest to understand how breast cancer cells resist treatment

HSPH researchers discover potential target to treat type 2 diabetes and other metabolic diseases

Scientists identify TR4 protein that drives the formation of pituitary tumors in Cushing's disease

Vanderbilt raises awareness of dangers associated with distracted driving

IDIBELL signs patent licensing agreement with Minoryx

Cell Medica treats first pediatric patient in ASPIRE Trial

EPSRC-funded study explores feasibility of using natural fibres for cartilage repair

Study shows turning up few microRNAs may offer much anti-breast-cancer activity

Testing Stat5 gene amplification in prostate cancer patients could provide powerful therapy: Study

Research discovery may lead to effective new treatments for neurodegenerative disease

Clinical data of cabozantinib to be presented at ASCO meeting

Advances in lung cancer treatment have major impact on short- and long-term outcomes

New skin cancer drug successfully tested in humans

Isis begins clinical study of ISIS-STAT3 in patients with metastatic liver cancer

Janssen enrolls patients in expanded access program for mantle cell lymphoma

Biomedical engineers grow 3D human heart muscle that acts just like natural tissue

Complex network of molecules controls formation and activity of neuronal connections

Concordia professor publishes new findings on cross-cultural commonalities associated with suicide

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Why use light scattering to analyze proteins and viral vectors?

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