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Antiva raises $16 million in Series B financing to advance antiviral compound through Phase 1 clinical trials

Antiva Biosciences, Inc. (formerly Hera Therapeutics), a biopharmaceutical company developing antiviral therapeutics, today announced that it has raised $16 million in a Series B financing, its first institutional round.

6 Aug 2015

TSRI study shows single injection of blebbistatin drug prevents methamphetamine relapse in animal models

Recovering addicts often grapple with the ghosts of their addiction—memories that tempt them to relapse even after rehabilitation and months, or even years, of drug-free living.

5 Aug 2015

Pharmaxis, Synairgen partner to develop LOXL2 inhibitor to treat idiopathic pulmonary fibrosis

Australian pharmaceutical company Pharmaxis Ltd and UK biotechnology company Synairgen plc today announced they have entered into a research collaboration to develop a selective inhibitor to the lysyl oxidase type 2 enzyme (LOXL2) to treat the fatal lung disease idiopathic pulmonary fibrosis (IPF).

5 Aug 2015

BrightFocus announces recipients of 2015 research program grants

BrightFocus Foundation, which funds research worldwide on Alzheimer's disease, glaucoma, and macular degeneration, today announced that its 2015 research program grants have been awarded to 58 scientists in 20 states and 7 foreign countries. Part of an $11 million research investment, the grants reflect the largest annual research funding in the foundation's history.

4 Aug 2015

New chemical reaction breaks strongest bond in molecules instead of weakest

Researchers at Princeton have developed a new chemical reaction that breaks the strongest bond in a molecule instead of the weakest, completely reversing the norm for reactions in which bonds are evenly split to form reactive intermediates.

30 Jul 2015

New research shows promising progress in use of anti-inflammatory cytokine for T1D treatment

New research from Uppsala University shows promising progress in the use of anti-inflammatory cytokine for treatment of type 1 diabetes. The study, published in the open access journal Scientific Reports (Nature Publishing Group), reveals that administration of interleukin-35 (a protein made by immune cells) to mice with type 1 diabetes, reverses or cures the disease by maintaining a normal blood glucose level and the immune tolerance.

30 Jul 2015

Researchers demonstrate direct connection between NOX proteins and liver fibrosis

Researchers at the University of California, San Diego School of Medicine have demonstrated a direct connection between two signaling proteins and liver fibrosis, a scarring process underlying chronic liver disease, the 12th leading cause of death in the United States.

30 Jul 2015

Natural protein fragment produced in the brain can inhibit enzyme implicated in Alzheimer's disease

For the first time, UCLA researchers have shown that a natural protein fragment produced in the brain can act as an inhibitor of a key enzyme implicated in the onset of Alzheimer's disease, a finding that could lead to the development of new drugs to treat the disease.

30 Jul 2015

Aeterna Zentaris selects optimized Erk inhibitor molecule for further development

Aeterna Zentaris Inc. today announced it has selected an optimized Erk inhibitor molecule for development, thus achieving another important milestone in the development of a new class of potential cancer therapies.

29 Jul 2015

Research findings may provide new approach to treating male infertility

A team of researchers from the National University of Singapore's (NUS) Yong Loo Lin School of Medicine has demonstrated for the first time that hydrogen sulphide (H2S), when applied exogenously, could protect testicular germ cells, which are male reproductive cells, against heat-induced injury, which is one of the major causes of male infertility.

28 Jul 2015

Scientists develop exercise mimic molecule that could help treat type 2 diabetes and obesity

Scientists from the University of Southampton have developed a molecule that acts as an exercise mimic, which could potentially help treat type 2 diabetes and obesity.

28 Jul 2015

New paper describes positive effects of CRAC channel inhibitors in animal models of acute pancreatitis

Researchers from CalciMedica, Inc. and the University of Liverpool today announced the publication of a paper describing positive effects of calcium release-activated calcium (CRAC) channel inhibitors in animal models of acute pancreatitis. The paper, titled "Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models" appears in the August edition of the journal Gastroenterology.

25 Jul 2015

New computer algorithm helps scientists see drug's activity inside the body

Researchers at Columbia University Medical Center have developed a computer algorithm that is helping scientists see how drugs produce pharmacological effects inside the body. The study, published in the journal Cell, could help researchers create drugs that are more efficient and less prone to side effects, suggest ways to regulate a drug's activity, and identify novel therapeutic uses for new and existing compounds.

24 Jul 2015

MSU scientists suggest that common glaucoma medication could be used to treat TB

A new discovery by Michigan State University scientists suggests that a common medication used to treat glaucoma could also be used to treat tuberculosis, even the drug-resistant kind.

24 Jul 2015

PharmaMar, TTY Biopharm sign agreement to market and distribute APLIDIN (plitidepsin) in Taiwan

PharmaMar has entered into an exclusive license and commercialization agreement with the pharmaceutical company TTY Biopharm to market and distribute the drug candidate APLIDIN (plitidepsin) in Taiwan. Under the terms of the agreement, PharmaMar will receive an upfront payment, royalties and additional remunerations for regulatory milestones achieved by APLIDIN (plitidepsin).

23 Jul 2015

UC San Diego researchers identify pivotal player in diabetic kidney disease

Tapping the potential of metabolomics, an emerging field focused on the chemical processes of metabolism, researchers at University of California, San Diego School of Medicine have identified a new and pivotal player in diabetic kidney disease.

23 Jul 2015

New TripAdvisor-style website launched to help researchers choose better tools for biomedical research

An international panel of leading scientists is launching a new TripAdvisor-style website aimed at helping researchers choose better-quality research tools - and avoiding potentially serious errors in biomedical research.

22 Jul 2015

Common environmental chemicals may act separately or together to increase risk of cancer

Common environmental chemicals assumed to be safe at low doses may act separately or together to disrupt human tissues in ways that eventually lead to cancer, according to a task force of nearly 200 scientists from 28 countries, including one from Oregon State University.

22 Jul 2015

New study suggests novel ways to treat serous retinal detachment

Wet age-related macular degeneration (AMD) is the leading cause of severe vision loss in older individuals. AMD and other serious chronic eye problems that affect younger individuals result when fluid accumulates abnormally under or within the retina. A new study published in The American Journal of Pathology shows for the first time that the release of substances from mast cells may be a causal factor in this type of eye pathology, and inhibitors of this release may offer new ways to treat serous retinal detachment.

22 Jul 2015

MD Anderson researchers find high prevalence of hereditary CRC among people diagnosed before the age of 35

Hereditary colorectal cancers, caused by inherited gene mutations, are relatively rare for most patients. However, researchers at The University of Texas MD Anderson Cancer Center have discovered a particularly high prevalence of hereditary cancers among those diagnosed with the disease before the age of 35. They suggest that these patients should undergo genetic counseling to determine if their families may be at an elevated risk.

21 Jul 2015

Compound News and Research

Antiva raises $16 million in Series B financing to advance antiviral compound through Phase 1 clinical trials

TSRI study shows single injection of blebbistatin drug prevents methamphetamine relapse in animal models

Pharmaxis, Synairgen partner to develop LOXL2 inhibitor to treat idiopathic pulmonary fibrosis

BrightFocus announces recipients of 2015 research program grants

New chemical reaction breaks strongest bond in molecules instead of weakest

New research shows promising progress in use of anti-inflammatory cytokine for T1D treatment

Researchers demonstrate direct connection between NOX proteins and liver fibrosis

Natural protein fragment produced in the brain can inhibit enzyme implicated in Alzheimer's disease

Aeterna Zentaris selects optimized Erk inhibitor molecule for further development

Research findings may provide new approach to treating male infertility

Scientists develop exercise mimic molecule that could help treat type 2 diabetes and obesity

New paper describes positive effects of CRAC channel inhibitors in animal models of acute pancreatitis

New computer algorithm helps scientists see drug's activity inside the body

MSU scientists suggest that common glaucoma medication could be used to treat TB

PharmaMar, TTY Biopharm sign agreement to market and distribute APLIDIN (plitidepsin) in Taiwan

UC San Diego researchers identify pivotal player in diabetic kidney disease

New TripAdvisor-style website launched to help researchers choose better tools for biomedical research

Common environmental chemicals may act separately or together to increase risk of cancer

New study suggests novel ways to treat serous retinal detachment

MD Anderson researchers find high prevalence of hereditary CRC among people diagnosed before the age of 35

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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