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Study provides new insights into the molecular causes of rare, fatal hereditary disease

A study entitled "IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport", now published in the open access journal "Cellular and Molecular Life Sciences", provides new insights into the molecular causes of a rare and usually fatal hereditary disease called MEDS1.

28 Oct 2024

Researchers uncover key mechanisms of CRISPR gene editing

CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy.

28 Oct 2024

New research unveils mechanism behind deadly neuroendocrine prostate cancer

A leading scientist whose discoveries about prostate cancer led to lifesaving treatments is now shedding light on an emerging and deadlier form of the disease: neuroendocrine prostate cancer (NEPC).

28 Oct 2024

Unlocking the secrets of Usher syndrome

The mistakes are small but carry severe consequences: In Usher syndrome, genetic mutations cause both hearing and vision loss. Cell biologist Professor Uwe Wolfrum from Mainz University is researching the molecular background of this rare genetic disorder - supported by foundations and, not least, by affected individuals themselves

28 Oct 2024

Novel gene therapy PS-002 targets podocytes in IgA nephropathy

IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition's pathogenesis.

27 Oct 2024

MALDI-TOF mass spectrometry proves effective for diagnosing onychomycosis in nail psoriasis

Nail psoriasis is common in patients with plaque psoriasis and is associated with morbidity, including onychomycosis, which can complicate psoriasis treatments and be difficult to differentiate.

26 Oct 2024

New analysis confirms canagliflozin's cardiovascular and kidney benefits in older adults

Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients' age.

26 Oct 2024

Study: GLP-1RA not associated with acute kidney injury risk during anti-cancer treatments

Glucagon-like peptide-1-receptor agonists (GLP-1RA) are medications that are increasingly prescribed for patients with type 2 diabetes and congestive heart failure. Reports of GLP-1RA–associated acute kidney injury (AKI) have emerged, but the risk of GLP-1RA–associated AKI among patients on anti-cancer drugs is unclear.

26 Oct 2024

New research trial aims to address a disabling post-stroke condition

A major new research trial led by academics at the University of East Anglia (UEA) and taking place at eight major stroke centres across England, will test the efficacy of a new therapy for a disabling post-stroke condition that affects around one in three survivors, thanks to a £1.26m grant from the Efficacy and Mechanism Evaluation (EME) Programme - a partnership between the National Institute for Health and Care Research (NIHR) and the Medical Research Council (MRC).

26 Oct 2024

Extracellular vesicles play key role in cancer drug resistance

Despite significant advancements in cancer treatment, drug resistance remains a persistent challenge. Cancer cells can often develop resistance to treatments such as chemotherapy, radiotherapy, and immunotherapy, leading to reduced treatment efficacy.

25 Oct 2024

Study: High prevalence of depression found among people living with HIV in Nigeria

Depression can lead to poor outcomes during antiretroviral therapy, and current evidence suggests high rates of depression among people living with human immunodeficiency virus (PLHIV), especially in low-and middle-income countries.

25 Oct 2024

Tertiary lymphoid structures linked to improved outcomes in liver cancer patients

A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center.

25 Oct 2024

RNA modifications and their role in cancer development

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications.

25 Oct 2024

Single treatment with CRISPR gene editing therapy offers hope for hereditary angioedema patients

A single treatment with, a CRISPR-Cas9 based gene editing therapy, is enough to replace the daily medication of patients with hereditary angioedema (HAE), a condition characterized by severe, painful and sudden onset of swelling, sometimes resulting in death.

25 Oct 2024

Daily internet use supercharges your memory!

Frequent internet use is linked to improved episodic memory, with daily users performing better in memory tasks than those who use it less often. The study suggests digital engagement may enhance cognitive abilities over time.

24 Oct 2024

Research highlights importance of quality improvement programs in stroke care

New research published this month shows the key role quality improvement programs play in ensuring hospitals can adequately fight one of the biggest public health threats facing our country: stroke.

24 Oct 2024

New drug TYRA-300 shows effectiveness in treating metastatic bladder cancer

Patients with advanced bladder cancer that had spread to other parts of the body (metastasized) have responded well in a phase I clinical trial of an investigational drug, TYRA-300.

24 Oct 2024

At-home phototherapy proves effective for psoriasis treatment

For decades, people with psoriasis have been treated in clinics with narrowband ultraviolet B phototherapy, or light therapy, to reduce sores, scales, and inflammation.

24 Oct 2024

Targeted therapy and immunotherapy improve outcomes in rare thyroid cancer

Researchers from The University of Texas MD Anderson Cancer Center demonstrated that anti-PD-L1 immunotherapy in combination with mutation-directed targeted therapy extended overall survival (OS) in patients with anaplastic thyroid carcinoma (ATC). Findings from the Phase II single center study published today in JAMA Oncology.

24 Oct 2024

Researchers develop first-of-its-kind therapy to enhance heart repair after a heart attack

Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind experimental therapy that has the potential to enhance heart repair following a heart attack, preventing the onset of heart failure.

24 Oct 2024

Therapy News and Research

Study provides new insights into the molecular causes of rare, fatal hereditary disease

Researchers uncover key mechanisms of CRISPR gene editing

New research unveils mechanism behind deadly neuroendocrine prostate cancer

Unlocking the secrets of Usher syndrome

Novel gene therapy PS-002 targets podocytes in IgA nephropathy

MALDI-TOF mass spectrometry proves effective for diagnosing onychomycosis in nail psoriasis

New analysis confirms canagliflozin's cardiovascular and kidney benefits in older adults

Study: GLP-1RA not associated with acute kidney injury risk during anti-cancer treatments

New research trial aims to address a disabling post-stroke condition

Extracellular vesicles play key role in cancer drug resistance

Study: High prevalence of depression found among people living with HIV in Nigeria

Tertiary lymphoid structures linked to improved outcomes in liver cancer patients

RNA modifications and their role in cancer development

Single treatment with CRISPR gene editing therapy offers hope for hereditary angioedema patients

Daily internet use supercharges your memory!

Research highlights importance of quality improvement programs in stroke care

New drug TYRA-300 shows effectiveness in treating metastatic bladder cancer

At-home phototherapy proves effective for psoriasis treatment

Targeted therapy and immunotherapy improve outcomes in rare thyroid cancer

Researchers develop first-of-its-kind therapy to enhance heart repair after a heart attack

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