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Promising development for women with triple-negative breast cancer

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer.

24 Apr 2013

Researchers decode toggle switch that can stimulate fat burning

For a long time, scientists have dreamt of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten a step closer to this goal: They decoded a "toggle switch" in mice which can significantly stimulate fat burning.

24 Apr 2013

Nanogels to attack lupus: an interview with Dr Look and Dr Fahmy, Yale University

Nanogels are synthetic particles that can be used for drug delivery. They are approximately 100 nm to 200 nm in diameter, and are made from safe, biocompatible materials: a gel-like interior and a lipid exterior.

24 Apr 2013

Research project to identify mechanisms underlying effects of cancer drug interferon-α

The immune system plays a decisive role in the fight against tumor cells. However, when tumor cells themselves prevent activation of the immune system, the immune system fails to destroy cancer cells.

24 Apr 2013

Study: Nearly two-thirds of children receiving stem cell transplants return to hospital within six months

Nearly two-thirds of children receiving stem cell transplants returned to the hospital within six months for treatment of unexplained fevers, infections or other problems, according to a study performed at Dana-Farber/Children's Hospital Cancer Center in Boston.

24 Apr 2013

CytRx reaches agreement with FDA for aldoxorubicin Phase 3 trial for treatment of soft tissue sarcomas

CytRx Corporation, a biopharmaceutical research and development company specializing in oncology, announced today that it has reached an agreement with the U.S. Food and Drug Administration under a special protocol assessment for a global pivotal Phase 3 trial with aldoxorubicin as a treatment for patients with soft tissue sarcomas who have relapsed or were refractory following prior treatment with chemotherapy.

24 Apr 2013

Thermo Scientific Scientific launches HyPerforma SUM DS 300 system for multiple uses

Thermo Fisher Scientific Inc., the world leader in serving science, today introduced the Thermo Scientific HyPerforma Single-Use Mixer DS 300 system, an innovative, cost-effective single-use mixer ideal for pilot-scale liquid preparations for vaccine and biologic manufacturing.

From Thermo Fisher Scientific Inc. 24 Apr 2013

Methodist Hospital will soon have new brain and pituitary tumor treatment center

Brain and pituitary tumor patients will soon have access to a state-of-the-art facility at The Methodist Hospital, a result of a $10 million dollar commitment from a Houston oil executive.

24 Apr 2013

Researchers studying lipids to learn more about normal, abnormal biology

When you have your cholesterol checked, the doctor typically gives you levels of three fats found in the blood: LDL, HDL and triglycerides. But did you know your body contains thousands of other types of fats, or lipids?

24 Apr 2013

Investigational treatment for ALS passes early phase clinical trial for safety

An investigational treatment for an inherited form of Lou Gehrig's disease has passed an early phase clinical trial for safety, researchers at Washington University School of Medicine in St. Louis and Massachusetts General Hospital report.

24 Apr 2013

Data from MK-5172 Phase II study for treatment of HCV genotype 1 infection to be presented at EASL meeting

Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced the presentation of the latest interim data from a Phase II, multi-center, randomized, dose-ranging clinical trial evaluating the safety and antiviral activity of MK-5172, for the treatment of chronic hepatitis C virus genotype 1 infection.

24 Apr 2013

Frequent binge drinking in college increases risk of cardiovascular disease later in life

Frequent binge drinking in college can cause more than a hangover. Regularly consuming multiple drinks in a short window of time can cause immediate changes in circulation that increase an otherwise healthy young adult's risk of developing cardiovascular disease later in life, according to research published online today in the Journal of the American College of Cardiology.

24 Apr 2013

Research shows sophisticated genetic circuits allow individual bacterium to act on its own

Individual freedom and social responsibility may sound like humanistic concepts, but an investigation of the genetic circuitry of bacteria suggests that even the simplest creatures can make difficult choices that strike a balance between selflessness and selfishness.

23 Apr 2013

Study shows intraventricular chemotherapy increases overall survival in LMC patients

Lung cancer is one of the most common primary cancers that cause leptomeningeal carcinomatosis (LMC), when cancer spreads to the membranes surrounding the spinal cord and brain. Cases of LMC have increased because of the improved survival of lung cancer patients with the help of new advances in treatment.

23 Apr 2013

Study suggests lung cancer patients with HER2 mutations may benefit from anti-HER2 drugs

New results from a retrospective study conducted in Europe suggest that anti-HER2 treatments, like the widely used breast cancer agent trastuzumab (Herceptin), have anti-cancer effects in a small subset of patients with advanced non-small cell lung cancer (NSCLC) harboring specific HER2 protein mutations.

23 Apr 2013

Individual cancer cells in blood stream are responsible for metastases in breast cancer patients

Individual cancer cells that break away from the original tumor and circulate through the blood stream are considered responsible for the development of metastases. These dreaded secondary tumors are the main cause of cancer-related deaths.

23 Apr 2013

Animal models of Huntington's disease allow better insights into disease's genetics

Scientific progress in Huntington's disease (HD) relies upon the availability of appropriate animal models that enable insights into the disease's genetics and/or pathophysiology.

23 Apr 2013

Review summarises current data on markers for pancreatic cancer

A team of researchers of the UPV/EHU together with researchers from the Hospital Clínico of Barcelona have produced a bibliographical review that summarises the data currently existing on the markers for pancreatic cancer, and have published it in the specialised journal Clinica Chimica Acta.

23 Apr 2013

Researchers find deficiency in anti-tumor protein can delay DNA repair after radiation treatment

Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression of two enzymes (JMJD2b and SUV39H1) that control the folding of DNA.

23 Apr 2013

Scientists discover new agent that removes potentially dangerous cells

Pluripotent stem cells can turn, or differentiate, into any cell type in the body, such as nerve, muscle or bone, but inevitably some of these stem cells fail to differentiate and end up mixed in with their newly differentiated daughter cells.

23 Apr 2013

Cell News and Research

Promising development for women with triple-negative breast cancer

Researchers decode toggle switch that can stimulate fat burning

Nanogels to attack lupus: an interview with Dr Look and Dr Fahmy, Yale University

Research project to identify mechanisms underlying effects of cancer drug interferon-α

Study: Nearly two-thirds of children receiving stem cell transplants return to hospital within six months

CytRx reaches agreement with FDA for aldoxorubicin Phase 3 trial for treatment of soft tissue sarcomas

Thermo Scientific Scientific launches HyPerforma SUM DS 300 system for multiple uses

Methodist Hospital will soon have new brain and pituitary tumor treatment center

Researchers studying lipids to learn more about normal, abnormal biology

Investigational treatment for ALS passes early phase clinical trial for safety

Data from MK-5172 Phase II study for treatment of HCV genotype 1 infection to be presented at EASL meeting

Frequent binge drinking in college increases risk of cardiovascular disease later in life

Research shows sophisticated genetic circuits allow individual bacterium to act on its own

Study shows intraventricular chemotherapy increases overall survival in LMC patients

Study suggests lung cancer patients with HER2 mutations may benefit from anti-HER2 drugs

Individual cancer cells in blood stream are responsible for metastases in breast cancer patients

Animal models of Huntington's disease allow better insights into disease's genetics

Review summarises current data on markers for pancreatic cancer

Researchers find deficiency in anti-tumor protein can delay DNA repair after radiation treatment

Scientists discover new agent that removes potentially dangerous cells

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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