Protein C News and Research

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Radiation therapy prolongs life in men with recurrent prostate cancer

Men whose tumors recur after prostate cancer surgery are three times more likely to survive their disease long term if they undergo radiotherapy within two years of the recurrence. Surprisingly, survival benefits were best in men whose new tumors were growing fastest, according to results of a 'look-back' study of 635 men by Johns Hopkins Medical Institutions researchers reported June 18 in the Journal of the American Medical Association.

17 Jun 2008

Magnetic resonance studies find clear differences between the structures of infectious and non-infectious prions

Infectious proteins known as prions have been identified as the cause of "mad cow" disease (BSE). The culprits are "incorrectly folded" proteins that can "infect" healthy proteins. The molecular bases for such prion diseases are not yet fully understood.

17 Jun 2008

Molecular imaging helps follow the progression of Alzheimer's disease

In the past, physicians were able only to follow the progression of Alzheimer's disease (AD) through careful clinical histories, noting the often subtle changes associated with cognitive decline over a number of years.

16 Jun 2008

New hope for patients with breast cancers resistant to tamoxifen

Researchers have found a new family of therapeutic agents that interferes with the ability of estrogen to stimulate the growth of breast cancer cells. The results of the new study will be presented by Nicole Patterson at The Endocrine Society's 90th Annual Meeting in San Francisco.

16 Jun 2008

Novel agents found to inhibit growth of estrogen-dependent breast cancer cells

Researchers have discovered a new family of agents that inhibit the growth of estrogen-dependent breast cancer cells. The finding, described at a meeting of the Endocrine Society, has opened an avenue of research into new drugs to combat estrogen-dependent breast cancers.

16 Jun 2008

Gene radiotherapy system shows promise for fighting treatment-resistant cancer cells

A gene radiotherapy system that detects and treats cancer cells that are resistant to traditional forms of chemotherapy and radiation showed success in the laboratory and could eventually prove beneficial for cancer patients, according to researchers at the Society of Nuclear Medicine's 55th Annual Meeting.

16 Jun 2008

Aerobics increases blood protein that may suppress appetite

Three months of aerobic exercise decreased body fat and calorie intake in overweight and obese people, according to a new study, and the researchers believe that changes to a central nervous system factor are responsible. The results will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

16 Jun 2008

Compound in grapes and red wine may help battle obesity

Resveratrol, a compound present in grapes and red wine, reduces the number of fat cells and may one day be used to treat or prevent obesity, according to a new study. The results will be presented at The Endocrine Society's 90th Annual Meeting in San Francisco.

16 Jun 2008

Discovery of mechanisms that direct cholinergic synapse assembly between neurons in vivo

Rapid information processing in the nervous system requires synapses, specialized contact sites between nerve cells and their targets. One particular synapse type, cholinergic, uses the chemical transmitter acetylcholine to communicate between nerve cells. Cholinergic synapses are essential for normal learning and memory, arousal, attention, and all autonomic (involuntary) nervous system functions.

16 Jun 2008

Fluorescent-probe in worm creates real-time "view" of cellular stress

Scientists at the University at Buffalo have created a mutant worm that changes color when it moves. The color change is generated by an optical sensor called stFRET. The sensor is composed of a pair of fluorescent molecules connected by a molecular spring that is inserted into structural proteins in the worm's cells.

16 Jun 2008

PolyTherics and Alligator Bioscience announce strategic collaboration for optimisation of next generation biopharmaceuticals

PolyTherics Ltd, a biopharmaceutical company specialised in the targeted application of polymers to biopharmaceuticals, and Alligator Bioscience AB ("Alligator"), a biotechnology company applying proprietary technology to the improvement of proteins, today announced the establishment of a new alliance.

16 Jun 2008

European researchers take lid off the genome

European researchers have made significant progress unravelling how genes are governed and why this sometimes goes wrong in disease.

15 Jun 2008

Collaborative effort by FDA and EMEA expected to yield additional safety data when assessing new drugs

In the first use of a framework allowing submission of a single application to the two agencies, the Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) worked together to allow drug companies to submit the results of seven new tests that evaluate kidney damage during animal studies of new drugs. The tests measure the levels of seven key proteins or "biomarkers" found in urine that can provide additional information about drug-induced damage to kidney cells, also known as renal toxicity.

15 Jun 2008

Nanoparticle delivers antisense agent to tumors

A multifunctional drug delivery system consisting of a lipid-based nanoparticle, a standard anticancer drug, and a short nucleic acid designed to augment the activity of that drug has demonstrated the ability to treat drug-resistant tumor cells.

15 Jun 2008

Targeted quantum rods probe blood-brain barrier

One of the chief difficulties in treating brain tumors involves getting potential tumor-killing drugs across the blood-brain barrier and into the brain.

15 Jun 2008

New technique provides greater understanding of how drugs get in and out of cells in our bodies

A team led by female scientists at the Universities of Bristol and Cambridge has developed an exciting new technique which may lead to a greater understanding of how drugs get in and out of the cells in our bodies. The method identifies the structures that guard the entrance and exits to cells.

15 Jun 2008

Protein C News and Research

Radiation therapy prolongs life in men with recurrent prostate cancer

Magnetic resonance studies find clear differences between the structures of infectious and non-infectious prions

Molecular imaging helps follow the progression of Alzheimer's disease

New hope for patients with breast cancers resistant to tamoxifen

Novel agents found to inhibit growth of estrogen-dependent breast cancer cells

Gene radiotherapy system shows promise for fighting treatment-resistant cancer cells

Aerobics increases blood protein that may suppress appetite

Compound in grapes and red wine may help battle obesity

Discovery of mechanisms that direct cholinergic synapse assembly between neurons in vivo

Fluorescent-probe in worm creates real-time "view" of cellular stress

PolyTherics and Alligator Bioscience announce strategic collaboration for optimisation of next generation biopharmaceuticals

European researchers take lid off the genome

Collaborative effort by FDA and EMEA expected to yield additional safety data when assessing new drugs

Nanoparticle delivers antisense agent to tumors

Targeted quantum rods probe blood-brain barrier

New technique provides greater understanding of how drugs get in and out of cells in our bodies

Scientists identify molecular trick that may explain part of Salmonella's fierceness

Researchers find gamma-secretase modulators being tested for Alzheimer’s work in unexpected and beneficial ways

Smad proteins regulate microRNA processing

Compugen announces discovery of novel drug targets for cancer antibody therapeutics

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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