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AKT inhibitor shows promise in a trial matching new treatments to cancer patients based on genetic make-up of tumors

In a trial matching new treatments to cancer patients based on the genetic make-up of their tumors, 22% of the patients treated with the AKT inhibitor drug ipatasertib had their tumors shrink.

27 Oct 2022

Study elucidates mechanism that is crucial for making hemophilia therapy effective

Hemophilia A is the most common severe form of hemophilia. It affects almost exclusively males. The disease can usually be treated well, but not for all sufferers.

27 Oct 2022

Research opens up new avenues for overcoming treatment resistance in colorectal cancer

Colorectal cancer is one of the most common cancers. Its treatment is mainly based on chemotherapy. However, over time, chemotherapy induces resistance in the majority of patients, who end up being unresponsive to the drugs.

27 Oct 2022

Advanced type of nanoparticle could help fight hard-to-treat cancers

Nanoparticles, or tiny molecules that can deliver a payload of drug treatments and other agents, show great promise for treating cancers.

27 Oct 2022

Study finds sexual dimorphism in the development of vascular insulin resistance induced by obesogenic lifestyle

A new study from the University of Missouri School of Medicine is the first evidence in humans that short-term lifestyle changes can disrupt the response to insulin of blood vessels. It's also the first study to show men and women react differently to these changes.

27 Oct 2022

Discovery points to a new understanding of Stargardt disease progression

Using a new stem-cell-based model made from skin cells, scientists found the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE).

27 Oct 2022

Study examines the severity of the SARS-CoV-2 Omicron BA.2 subvariant

In a recent study that represents the largest to date to examine the severity of the SARS-CoV-2 Omicron BA.2 subvariant (the strain making a re-emergence this fall), a team led by investigators at Massachusetts General Hospital (MGH) determined that the BA.2 subvariant is less severe than the previous Delta variant and less severe to an even greater extent than the original Omicron variant.

27 Oct 2022

New discovery may change the textbook model of GPCR-mediated signaling

Researchers at University of California San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs.

27 Oct 2022

Pioneering gene editing technique can repair faulty T cells in patients with CTLA-4 insufficiency

A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.

27 Oct 2022

Studies find cardiovascular effects of cigarettes and e-cigarettes to be strikingly similar

Two related studies, one in humans and the other in rats, found that the cardiovascular effects of cigarettes and e-cigarettes are strikingly similar, and these harmful effects on blood vessel function are likely caused by airway irritation due to inhalation of a foreign substance, rather than a specific component of the cigarette smoke or e-cigarette vapor (aerosol), according to new research published today in the American Heart Association's peer-reviewed journal Arteriosclerosis, Thrombosis and Vascular Biology.

27 Oct 2022

Hydrogel bioink can bioprint conduits that mimic the mechanics of native blood vessels

Cardiovascular diseases (CVDs) remain among the leading causes of global morbidity and mortality. In patients with CVD, blood vessels-which transport blood, oxygen, and nutrients-can become constricted or obstructed, leading to numerous complications.

27 Oct 2022

Is vaccine status associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients?

Researchers assessed the impact of SARS-CoV-2 vaccination on the occurrence and severity of symptoms in SARS-CoV-2 Omicron-infected hospitalized patients.

27 Oct 2022

Rare variants of type I IFN immunity genes could underlie life-threatening COVID-19

Researchers assessed whether loss-of-function variants of type I interferon immunity genes are associated with life-threatening COVID-19.

27 Oct 2022

Montana switches gears to try to bargain for lower health care costs for employees

Montana is signaling it might step away from an innovative way of setting the prices its public employee health plan pays hospitals for services, an approach that has saved the state millions of dollars and become a model for health plans nationwide.

27 Oct 2022

Employers are concerned about covering workers’ mental health needs, survey finds

Almost three years after the covid-19 pandemic upended workplaces, mental health coverage remains a priority for employers, according to an annual employer survey fielded by KFF.

27 Oct 2022

Researchers develop new method to calculate the delay of signal propagations in brains of MS patients

Researchers of the Human Brain Project have developed a new methodology to calculate the delay of signal propagations in brains of patients suffering from multiple sclerosis, a chronic inflammatory disease that affects more than 2 million people worldwide.

27 Oct 2022

Metabolite product from pomegranate improves the function of immune cells to fight against cancer

As part of an interdisciplinary project of the LOEWE Centre Frankfurt Cancer Institute (FCI), researchers from the Georg-Speyer-Haus in Frankfurt am Main, Germany, and Goethe University Frankfurt have succeeded in identifying a new approach for the therapy of colorectal cancer.

27 Oct 2022

Research News and Research

AKT inhibitor shows promise in a trial matching new treatments to cancer patients based on genetic make-up of tumors

Study elucidates mechanism that is crucial for making hemophilia therapy effective

Research opens up new avenues for overcoming treatment resistance in colorectal cancer

Advanced type of nanoparticle could help fight hard-to-treat cancers

Study finds sexual dimorphism in the development of vascular insulin resistance induced by obesogenic lifestyle

Discovery points to a new understanding of Stargardt disease progression

Study examines the severity of the SARS-CoV-2 Omicron BA.2 subvariant

New discovery may change the textbook model of GPCR-mediated signaling

Pioneering gene editing technique can repair faulty T cells in patients with CTLA-4 insufficiency

Studies find cardiovascular effects of cigarettes and e-cigarettes to be strikingly similar

Hydrogel bioink can bioprint conduits that mimic the mechanics of native blood vessels

Is vaccine status associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients?

Rare variants of type I IFN immunity genes could underlie life-threatening COVID-19

Montana switches gears to try to bargain for lower health care costs for employees

Employers are concerned about covering workers’ mental health needs, survey finds

Researchers develop new method to calculate the delay of signal propagations in brains of MS patients

Metabolite product from pomegranate improves the function of immune cells to fight against cancer

Some healthcare workers vaccinated against COVID-19 show unexpectedly low responses to immunizations

Cells in the brain's blood vessels necessary for fever reaction

Unique gut bacteria could be responsible for triggering rheumatoid arthritis in at-risk people

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