Hydrogel bioink can bioprint conduits that mimic the mechanics of native blood vessels

Cardiovascular diseases (CVDs) remain among the leading causes of global morbidity and mortality. In patients with CVD, blood vessels-which transport blood, oxygen, and nutrients-can become constricted or obstructed, leading to numerous complications. While revascularization and grafting are common procedures carried out during surgeries, biofabricated grafts used during these operations can have many drawbacks, for example, weak mechanical strength.

To overcome these issues, researchers at the Brigham used bioengineering advancements to improve 3D bioprinting of vascular tissues with functional and mechanical hallmarks. The team used crosslinking properties of natural polymers to develop a double-network hydrogel bioink capable for bioprinting conduits. These conduits had key physiological characteristics of blood vessels including strong vasoconstriction, vasodilation, perfusability, and barrier performance comparable to native vessels. In line with the ongoing COVID-19 pandemic, the researchers also showed the possibility of using these vessels for SARS-CoV-2 pseudoviral testing.

The vessels we have printed truly mimic a lot of the mechanics of native vessels. This research demonstrates the potential for such conduits to serve as vascular models for grafts in vascular surgeries, other disease studies, and broad biomedical applications."

Y. Shrike Zhang, PhD, Senior Corresponding Author, Division of Engineering in Medicine

The other co-corresponding authors included Xuanhe Zhao, PhD, of the Department of Mechanical Engineering at MIT, and C. Keith Ozaki, MD, of the Division of Vascular and Endovascular Surgery at the Brigham.

Journal reference:

Wang, D., et al. (2022) Microfluidic Bioprinting of Tough Hydrogel-based Vascular Conduits for Functional Blood Vessels. Science Advances. doi.org/10.1126/sciadv.abq6900.


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