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New research shows safety can be improved for people participating in medical experiments

In almost 90 per cent of cases, novel drugs tested on humans by pharmaceutical companies do not work as intended and must be scrapped. Often the drugs do not work, while at worst, test subjects die. New research from the University of Southern Denmark now shows that this number can be reduced.

12 Apr 2013

Researchers identify two specific tumor suppressor genes associated with breast cancer

Research led by Dr. Suresh Alahari, Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, is the first to report that two specific tumor suppressor genes work in concert to inhibit the growth and spread of breast tumor cells to the lungs.

12 Apr 2013

Targeting pathway may lead to better hypertension treatments for at-risk patients

Obesity, heart disease, and high blood pressure (hypertension) are all related, but understanding the molecular pathways that underlie cause and effect is complicated.

12 Apr 2013

MKK4 gene could be a promising therapeutic target for liver disease, study reveals

Chronic liver failure is a major health problem that causes about one million deaths around the world each year. A study published April 11th by Cell Press in the journal Cell reveals a new type of screen for identifying genes that promote liver repair in mouse models of both acute and chronic liver disease.

12 Apr 2013

Researchers identify defective gene responsible for isolated congenital asplenia

The spleen is rarely noticed, until it is missing. In children born without this organ, that doesn't happen until they become sick with life-threatening bacterial infections.

12 Apr 2013

Research on soy-based treatment for colorectal cancer presented at AACR annual meeting

Research on a soy-based treatment for colorectal cancer, a promising agent in ovarian cancer, and a new drug target for advanced prostate cancer was presented at the American Association for Cancer Research 2013 Annual Meeting.

12 Apr 2013

Researchers show how Src kinase influences inner workings of cells

Researchers at the University of North Carolina at Chapel Hill School of Medicine have "rationally rewired" some of the cell's smallest components to create proteins that can be switched on or off by command.

12 Apr 2013

Weight loss surgery causes changes in DNA modifications

Gastric bypass surgery can drastically reduce the body weight of obese individuals in a short timeframe. For reasons that are not entirely clear, the surgery also leads to early remission of type 2 diabetes in the vast majority of patients.

12 Apr 2013

Rising temperature induces key changes in dengue virus

Researchers have discovered that rising temperature induces key changes in the dengue virus when it enters its human host, and the findings represent a new approach for designing vaccines against the aggressive mosquito-borne pathogen.

12 Apr 2013

Study opens new avenues of research to improve care for patients with COPD

Researchers from Boston University School of Medicine have pinpointed a genetic signature for chronic obstructive pulmonary disease from airway cells harvested utilizing a minimally invasive procedure.

12 Apr 2013

Researchers determine 3D structure of two proteins for first time

A team led by David Reverter, a researcher at the Institute of Biotechnology and Biomedicine of the UAB, has determined for the first time the three-dimensional structure of a protein pair: LC8 and Nek9.

12 Apr 2013

Discovery suggests new therapeutic target for treating dysfunctional beta cells, type 2 diabetes

Researchers at the University of California, San Diego School of Medicine have identified a previously unknown biological mechanism involved in the regulation of pancreatic islet beta cells, whose role is to produce and release insulin.

12 Apr 2013

UT MD Anderson scientist receives AACR-CRI Lloyd J. Old Award in Cancer Immunology

The scientist whose discoveries led to the first drug approved for metastatic melanoma by "treating the immune system, not the cancer," also is the first to receive the AACR-CRI Lloyd J. Old Award in Cancer Immunology.

12 Apr 2013

Survey shows San Diego County drivers are distracted

According to experts in the Training, Research and Education for Driving Safety program at the University of California, San Diego School of Medicine, there were approximately 3,300 deaths and 400,000 injuries nationwide in 2011 due to collisions involving distracted driving.

11 Apr 2013

Androgen receptors found to be a potential target in breast cancer

Estrogen and progesterone receptors, and the gene HER2 - these are the big three markers and/or targets in breast cancer. Evidence presented at the AACR Annual Meeting 2013 adds a fourth: androgen receptors.

11 Apr 2013

Omeros' GPCR platform unlocks new drug targets against multiple sclerosis

Omeros Corporation today announced positive data in the most commonly used model for studying the clinical and pathological features of multiple sclerosis (MS), further advancing its development program of GPR17-targeting compounds for the treatment of MS. Compounds previously discovered by Omeros that inhibit GPR17, an orphan G protein-coupled receptor (GPCR) unlocked by Omeros, significantly improved function from experimental autoimmune encephalomyelitis (EAE) in mice.

11 Apr 2013

Gold nano-bullets to defeat cancer

Cutting edge research into an experimental therapy that deploys nano-particles of gold in the fight against cancer earned an Alberta high school student, 16, top national honours today in the 2013 "Sanofi BioGENEius Challenge Canada" (SBCC).

11 Apr 2013

OncoMed highlights progress of anti-cancer biologics at AACR annual meeting

OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer stem cells (CSCs), or tumor-initiating cells, today summarized new data highlighting the progress of OncoMed's pipeline of anti-cancer biologics presented this week in an oral presentation and five posters at the Annual Meeting of the American Association of Cancer Research in Washington, DC.

11 Apr 2013

Study demonstrates successful use of fat cells to support prolonged growth of human hematopoietic stem cells

One of the main obstacles that stands in the way of using human hematopoietic stem cells (hHSCs) to treat a variety of diseases is the difficulty growing them in culture—they quickly die or differentiate into other cell types. A series of experiments that demonstrate the successful use of fat cells as part of a feeder layer to support prolonged growth of hHSCs in culture is reported in an article in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers.

11 Apr 2013

New research reveals how autophagy keeps neural stem cells to replace damaged brain, nerve cells

Deep inside your brain, a legion of stem cells lies ready to turn into new brain and nerve cells whenever and wherever you need them most. While they wait, they keep themselves in a state of perpetual readiness - poised to become any type of nerve cell you might need as your cells age or get damaged.

11 Apr 2013

Cell News and Research

New research shows safety can be improved for people participating in medical experiments

Researchers identify two specific tumor suppressor genes associated with breast cancer

Targeting pathway may lead to better hypertension treatments for at-risk patients

MKK4 gene could be a promising therapeutic target for liver disease, study reveals

Researchers identify defective gene responsible for isolated congenital asplenia

Research on soy-based treatment for colorectal cancer presented at AACR annual meeting

Researchers show how Src kinase influences inner workings of cells

Weight loss surgery causes changes in DNA modifications

Rising temperature induces key changes in dengue virus

Study opens new avenues of research to improve care for patients with COPD

Researchers determine 3D structure of two proteins for first time

Discovery suggests new therapeutic target for treating dysfunctional beta cells, type 2 diabetes

UT MD Anderson scientist receives AACR-CRI Lloyd J. Old Award in Cancer Immunology

Survey shows San Diego County drivers are distracted

Androgen receptors found to be a potential target in breast cancer

Omeros' GPCR platform unlocks new drug targets against multiple sclerosis

Gold nano-bullets to defeat cancer

OncoMed highlights progress of anti-cancer biologics at AACR annual meeting

Study demonstrates successful use of fat cells to support prolonged growth of human hematopoietic stem cells

New research reveals how autophagy keeps neural stem cells to replace damaged brain, nerve cells

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