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Study: Atg2 tethers pre-autophagosomal membrane to endoplasmic reticulum during autophagosome formation

Postdoctoral Researcher Tetsuya Kotani, Associate Professor Hitoshi Nakatogawa, Honorary Professor Yoshinori Ohsumi and colleagues at Tokyo Institute of Technology have analyzed the Atg protein Atg2, whose function had been completely unknown, and have discovered that Atg2 tethers the pre-autophagosomal membrane to the endoplasmic reticulum during autophagosome formation.

23 Oct 2018

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., today announced detailed results from the Phase III SOLO-1 trial testing LYNPARZA (olaparib) 300 mg tablets twice-daily as a maintenance treatment for patients with newly diagnosed advanced BRCA-mutated ovarian cancer who were in complete or partial response following 1st-line standard platinum-based chemotherapy.

22 Oct 2018

Prion strain diversity may be greater than previously thought

The first example of prion strains that replicate independently in vitro and in vivo suggests that strain diversity may be greater than previously thought, according to a study published October 18 in the open-access journal PLOS Pathogens by Jason Bartz of Creighton University, and colleagues.

19 Oct 2018

Newly discovered compound shows potential for treating Parkinson's disease

A joint research group centered around Professor Hideyuki Okano and Associate Professor Jun Kohyama, Department of Physiology of the Keio University School of Medicine, together with a research group of Eisai Co., Ltd. has identified a compound that has the potential to be a treatment for Parkinson's disease by using dopaminergic neurons differentiated from induced pluripotent stem (iPS) cells from patients with familial Parkinson's disease.

19 Oct 2018

Mice study shows antibiotics are not always necessary to cure sepsis

Biochemists, microbiologists, drug discovery experts and infectious disease doctors have teamed up in a new study that shows antibiotics are not always necessary to cure sepsis in mice.

17 Oct 2018

Using Galleria mellonella to assess acute toxicity of chemicals

TruLarv is considered a non-animal technology in the context of UK animal use regulations where procedures on this species are not regulated.

17 Oct 2018

Researchers discover why heart contractions are weaker in individuals with HCM

When a young athlete suddenly dies of a heart attack, chances are high that they suffer from familial hypertrophic cardiomyopathy. Itis the most common genetic heart disease in the US and affects an estimated 1 in 500 people around the world.

17 Oct 2018

Study uses novel approach to investigate genetic origins of mental illnesses

A study in Biological Psychiatry has established a new analytical method for investigating the complex genetic origins of mental illnesses using brain cells that are grown in a dish from human embryonic stem cells.

16 Oct 2018

Tobacco heating products cause less staining to teeth than conventional cigarettes

A study by scientists at British American Tobacco has shown that e-cigarettes and tobacco heating products cause significantly less staining to teeth than conventional cigarettes.

15 Oct 2018

Researchers develop two-pronged approach for targeting Ebola virus

In a new study researchers have developed a two-pronged approach for targeting Ebola virus infection using linked nucleic acid (LNA) antisense oligonucleotides (ASOs)designed to interfere both genes essential for translation of Ebola virus genes and to block production of an intracellular human protein needed for the virus to enter cells.

12 Oct 2018

Synspira’s abstracts accepted for presentation at the 32nd Annual NACFC

Synspira, a privately held company developing a new class of inhaled glycopolymer-based therapeutics for the treatment of pulmonary disease, today announced that three abstracts have been accepted for presentation at the 32nd Annual North American Cystic Fibrosis Conference, occurring October 18-20 in Denver, CO.

12 Oct 2018

Cornell dots equipped with antibody fragments offer a new cancer weapon

Antibody-based imaging of a particularly aggressive form of breast cancer is undergoing clinical trials worldwide, but the path from trial to application is being hampered by a major obstacle: safety.

12 Oct 2018

Top journal publishes special issue on deep learning for drug discovery and biomarker development

While the many concepts in artificial intelligence date back to the 20th century, the revolution in deep learning started around 2014-2015 when AI systems started outperforming humans in many tasks ranging from video games and image recognition to autonomous driving.

11 Oct 2018

Otago scientists make a breakthrough in monkey malaria research

A breakthrough in monkey malaria research by University of Otago scientists encouraged the Bill & Melinda Gates Foundation to fund a special meeting in Dunedin recently.

11 Oct 2018

Scientists identify new biomarker for Alzheimer's disease of sporadic origin

The objective of the research, undertaken in the laboratories of the IBPM, is to develop a model for studying Alzheimer's disease of sporadic origin, in other words, not due to a hereditary genetic mutation.

10 Oct 2018

Antibody Screening Tools; Improving Workflows

Antibody screening tools have exponentially increased the rate that candidates can be screened, multiplexing will increase processing to thousands per hour.¬

From Sartorius 9 Oct 2018

Celmatix partners with Oncotest-Teva to bring Fertilome test to Israel

Today, Celmatix, a next-generation women's health company, has announced a commercial agreement with Oncotest-Teva Ltd, a subsidiary of Teva Pharmaceutical Industries Ltd. in Israel to bring the Fertilome test, the world's first multigene panel test for a woman's reproductive health and fertility, to the Israeli market.

9 Oct 2018

The feds’ termination of a tiny contract inflames bitter fight over fetal tissue

Federal health officials announced late last month they had terminated their contract with a company that supplies human fetal tissue for medical research and were checking that similar contracts, as well as studies conducted with that tissue, comply with federal law.

8 Oct 2018