Cell Signaling News and Research

RSS

Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

Research finds drugs for better long-term treatment of poorly controlled asthma

The waning effectiveness of drugs over time continues to be a major challenge in treating diseases, including asthma.

11 Oct 2019

Common genetic variant explains why immunotherapy often fails in Crohn's disease

The reason why a commonly used range of immunotherapy drugs is not effective in some patients with Crohn’s disease has so far not been identified, until now.

7 Oct 2019

New link between two important products of nitric oxide discovered

Ever since three US-based researchers working independently unveiled the role of nitric oxide in mediating blood vessel dilation, endothelial cell contraction and smooth muscle relaxation, their discoveries have served as a basis for novel treatments for high blood pressure and erectile dysfunction, among other conditions.

4 Oct 2019

Study explores how macrophage specialization gets disrupted by liver disease

Every tissue in the human body has an immune cell in it called a macrophage. Macrophages play important roles in the immune system's initial response to bacteria, viruses and wounds.

4 Oct 2019

Diabetic mice benefit from increased ‘good’ cholesterol levels

A new study has looked into the artificial increase in the level of 'good' cholesterol and its link to the reversal of atherosclerosis in arteries.

30 Sep 2019

Cancer Research Institute declares 2019 recipients of top scientific and philanthropic awards

The Cancer Research Institute (CRI), a nonprofit organization dedicated to advancing the discovery and development of powerful immunotherapies for all forms of cancer, has announced the 2019 recipients of its highest scientific and philanthropic awards.

27 Sep 2019

Leukemia drug appears to be effective in treating deadly pediatric brain tumor

A drug used to treat chronic myeloid leukemia appears to be more effective at stopping a type of medulloblastoma in mouse models than existing treatments for the deadly pediatric brain tumor, reports a multi-institutional team led by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego.

21 Sep 2019

Researchers discover potential approach to treating diabetic retinopathy

Boston University researchers have identified an enzymatic precursor that is toxic to retinal cells and could be used in new treatments for diabetic retinopathy.

20 Sep 2019

Discovery opens up new opportunities to understand the genetics of cancer

University of Delaware molecular biologist Mona Batish and collaborators at Harvard Medical School and University of California, Los Angeles, have identified a new circular ribonucleic acid (RNA) that increases tumor activity in soft tissue and connective tissue tumors.

13 Sep 2019

Antioxidant compound proves effective in kidney ischemia-reperfusion treatment

Russian researchers from the Moscow Institute of Physics and Technology, the Institute of Cell Biophysics, and elsewhere have shown an antioxidant compound known as peroxiredoxin to be effective in treating kidney injury in mice.

9 Sep 2019

High-fat diets contribute to irregularities in hypothalamus region of the brain

Much research has pointed to how an unhealthy diet correlates to obesity, but has not explored how diet can bring about neurological changes in the brain.

9 Sep 2019

Exercise during pregnancy shown to restore metabolic health

A new study has shown that exercise can restore key tissues and reduce the risk of metabolic disorders such as type 2 diabetes.

2 Sep 2019

A single cholesterol-derived molecule promotes adiposity

A single cholesterol-derived molecule, called 27-hydroxycholesterol (27HC), lurks inside your bloodstream and will increase your body fat, even if you don't eat a diet filled with red meat and fried food. That kind of diet, however, will increase the levels of 27HC and body weight.

29 Aug 2019

U of T scientists create antibodies with enormous potential for regenerative medicine

Our body makes antibodies to fight infections. But the synthetic versions of these molecules could hold the key to stimulating the body's ability to regenerate.

27 Aug 2019

Study uncovers potential new treatment approach for lung cancer

Lung cancer is the second most common cancer found in both men and women. It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway.

19 Aug 2019

Study shows how plants coordinate their internal circadian clocks

From cyanobacteria to humans, nearly all living things on Earth have an internal circadian clock that regulates their activities on a 24-hour cycle.

From PLOS ONE 16 Aug 2019

Promising antibody therapy reduces tumor growth, increases survival in mice with pancreatic cancer

Scientists have found a way to target and knock out a single protein that they have discovered is widely involved in pancreatic cancer cell growth, survival and invasion.

31 Jul 2019

Researchers develop new compound to block therapeutic target in aggressive blood cancer

Researchers at the UNC Lineberger Comprehensive Cancer Center have discovered a hyperactive cell signal that contributes to tumor growth in an aggressive blood cancer.

23 Jul 2019

Exosomes can restore health to brain cells affected by developmental disease

Like overpacked suitcases unloaded from the underbelly of a jet, molecular satchels called exosomes are continuously deployed from all cells in the body—each one brimming with an assortment of contents that another cell may unpack and use.

23 Jul 2019

New study reveals 'clutch' proteins responsible for putting T cell activation 'into gear'

In collaborative research, scientists from three continents were able to discover a crucial bit of information about how T cells move proteins inside them to drive the immune response. This could help evolve specific new treatments centered on T cell selectivity.

12 Jul 2019