Mesenchymal Stem Cells News and Research

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Scientists develop nanocombinatorics for directing stem cell differentiation

Northwestern University scientists have developed a powerful analytical method that they have used to direct stem cell differentiation. Out of millions of possibilities, they rapidly identified the chemical and physical structures that can cue stem cells to become osteocytes, cells found in mature bone.

7 Mar 2012

Early MSC transplantation can help repair neonatal brain damage

In a study to be presented today at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting -, in Dallas, Texas, researchers will report that early transplantation of human placenta-derived mesenchymal stem cells into the lateral ventricles of neonatal rats with birth-related brain damage is possible, and that the donor cells can survive and migrate in the recipient's brain.

13 Feb 2012

Novel stem-cell technique to enhance bone growth

A research team led by UC Davis Health System scientists has developed a novel technique to enhance bone growth by using a molecule which, when injected into the bloodstream, directs the body's stem cells to travel to the surface of bones.

7 Feb 2012

Researchers derive vessel-forming stem cells from amniotic fluid

Researchers at Rice University and Texas Children's Hospital have turned stem cells from amniotic fluid into cells that form blood vessels. Their success offers hope that such stem cells may be used to grow tissue patches to repair infant hearts.

7 Feb 2012

Vigorous exercise triggers MSC accumulation in skeletal muscle

University of Illinois researchers determined that an adult stem cell present in muscle is responsive to exercise, a discovery that may provide a link between exercise and muscle health. The findings could lead to new therapeutic techniques using these cells to rehabilitate injured muscle and prevent or restore muscle loss with age.

6 Feb 2012

Creighton researcher to study role of adult stem cells in repairing damaged coronary arteries

A Creighton University School of Medicine researcher has received a $3.3 million, five-year grant from the National Institutes of Health to study what role adult stem cells might play in repairing damaged coronary arteries, a complication that often occurs in patients after they undergo angioplasty and stenting.

24 Jan 2012

MSC-mediated RNAi transfer holds promise for Huntington's disease

A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington's disease, a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death.

20 Jan 2012

Bioengineers receive $2 million NIH grant to develop new toxicology tests

Chemicals in pharmaceutical drugs can obviously save lives. But as more and stronger chemicals have been introduced, our basic knowledge of the broader health impact of all these chemicals has not kept up with the rapid pace of innovation. There is exceptionally little information on how chemicals in our drugs and also in the environment around us, including on the food we eat, impact some of the most important cells in our body: stem cells. Without basic knowledge and tests on the impact of chemicals on our stem cells, we may be unwittingly damaging essential regenerative functions in our body.

18 Jan 2012

Osiris provides update on Prochymal Phase 2 trial for type 1 diabetes

Osiris Therapeutics, Inc., today provided an update on its Phase 2 trial evaluating Prochymal, a formulation of adult mesenchymal stem cells (MSCs), in patients with newly diagnosed type 1 diabetes.

4 Jan 2012

New cancer research findings presented at 53rd ASH annual meeting

Researchers from Seidman Cancer Center at University Hospitals (UH) Case Medical Center and Case Western Reserve University School of Medicine presented new research findings in 25 presentations this weekend at the 53rd Annual Meeting of the American Society of Hematology (ASH) at the San Diego Convention Center.

12 Dec 2011

Moffitt investigators to participate with 16 oral and 50 posters presentations at 53rd ASH meeting

When the American Society of Hematology convenes its 53rd Annual Meeting and Exposition on Dec. 10-13 in San Diego, Calif., researchers from Moffitt Cancer Center will break a new record for Moffitt participants with one plenary presentation, 16 oral presentations and more than 50 poster presentations on new research results in a variety of meeting programs that focus on blood cancer basic science and clinical applications, including bone marrow transplantation and clinical trials results.

5 Dec 2011

Implantable replacement cartilages hold promise for damaged knees, shoulders, ears and noses

A lab discovery is a step toward implantable replacement cartilage, holding promise for knees, shoulders, ears and noses damaged by osteoarthritis, sports injuries and accidents.

3 Dec 2011

Study examines how mice with genetic bone defects respond to infusions of BMMSC

A new study in Nature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance of the transplant recipient's immune system in stem cell regeneration.

21 Nov 2011

Stem cell therapy for heart failure: two studies two successes

The Center for Disease Control and Prevention says that heart failure affects nearly 6 million Americans leading to considerable risk of death, diminished quality of like and recurrent hospitalizations. Heart failure occurs when the heart can no longer pump enough blood to the rest of the body. The most common cause of heart failure is coronary artery disease, which narrows the small blood vessels that supply blood and oxygen to the heart.

17 Nov 2011

EPO-secreting engineered vessels could reverse anemia

Patients who rely on recombinant, protein-based drugs must often endure frequent injections, often several times a week, or intravenous therapy. Researchers at Children's Hospital Boston demonstrate the possibility that blood vessels, made from genetically engineered cells, could secrete the drug on demand directly into the bloodstream.

15 Nov 2011

Stem cell markers can aid in determining origin of pediatric sarcomas

The authors of a report in the current issue of the journal Pediatric and Developmental Pathology sought to use stem cell markers as an aid in determining the cell of origin. The expression of stem cell-associated proteins shows differences that can help identify how the tumors evolve. Eighty-one tumors were analyzed, all diagnosed in patients under 18 years old.

10 Nov 2011

Gene therapy and stem cell transplantation successfully reverse hemophilia A

For the first time, researchers have combined gene therapy and stem cell transplantation to successfully reverse the severe, crippling bleeding disorder hemophilia A in large animals, opening the door to the development of new therapies for human patients.

3 Nov 2011

MSCs can be reprogrammed to have enhanced survival and therapeutic efficacy

Chinese stem cell scientists have published new research that improves the survival and effectiveness of transplanted stem cells. The research led by Dr Hsiao Chang Chan, from the Chinese University of Hong Kong, is published in Stem Cells.

3 Nov 2011

Young microenvironment rejuvenates old stem cells

Old stem cells can be rejuvenated by being placed in a young microenvironment, research from The University of Texas Health Science Center San Antonio shows. This raises the possibility that patients' own stem cells may one day be rescued and banked to treat their age-related diseases.

2 Nov 2011