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Genmab/GSK receive FDA sBLA approval for Arzerra in combination with chlorambucil for treatment of CLL

GlaxoSmithKline plc and Genmab A/S announced today that the U.S. Food and Drug Administration (FDA) has approved a Supplemental Biologic License Application (sBLA) for the use of Arzerra® (ofatumumab), a CD20-directed cytolytic monoclonal antibody, in combination with chlorambucil for the treatment of previously untreated patients with chronic lymphocytic leukaemia (CLL) for whom fludarabine-based therapy is considered inappropriate.

21 Apr 2014

EcoHealth Alliance examines the origins of Ebola virus outbreaks

EcoHealth Alliance, a nonprofit organization that focuses on conservation and global public health issues, published a comprehensive review today examining the current state of knowledge of the deadly Ebola and Marburg virus.

21 Apr 2014

Study sheds light on tiny environments that stem cells occupy in animal bodies

Johns Hopkins researchers have discovered an unexpected phenomenon in the organs that produce sperm in fruit flies: When a certain kind of stem cell is killed off experimentally, another group of non-stem cells can come out of retirement to replace them.

21 Apr 2014

Study suggests that improving newborns' bacterial environment could fend off infections

Mothers give a newborn baby a gift of germs-germs that help to kick-start the infant's immune system. But antibiotics, used to fend off infection, may paradoxically interrupt a newborn's own immune responses, leaving already-vulnerable premature babies more susceptible to dangerous pathogens.

21 Apr 2014

Researchers reveal connection between Down syndrome and acute lymphoblastic leukemia

Although doctors have long known that people with Down syndrome have a heightened risk of developing acute lymphoblastic leukemia (ALL) during childhood, they haven't been able to explain why. Now, a team of Dana-Farber Cancer Institute investigators has uncovered a connection between the two conditions.

21 Apr 2014

New device uses space-tested concept of capillary flow to diagnose infectious diseases

A new medical-testing device is being prepped to enter the battle against infectious disease. This instrument could improve diagnosis of certain diseases in remote areas, thanks in part to knowledge gained from a series of investigations aboard the International Space Station on the behavior of liquids. The device uses the space-tested concept of capillary flow to diagnose infectious diseases such as HIV/AIDS and tuberculosis.

20 Apr 2014

Three Johns Hopkins researchers awarded grants for work on potential treatments for diabetes

Three Johns Hopkins University School of Medicine researchers have been awarded two-year grants for their work on potential treatments for diabetes, Novo Nordisk announced this month. Of the 110 initial submissions to the new Novo Nordisk Diabetes and Obesity Biologics Science Forum Program, only four projects were funded, three of which are led by Johns Hopkins researchers. They are Jonathan Powell, M.D., Ph.D.; G. William Wong, Ph.D.; and Elias Zambidis, M.D., Ph.D.

19 Apr 2014

Researchers discover new marker derived from human umbilical cord blood

The development of stem cell therapies to cure a variety of diseases depends on the ability to characterize stem cell populations based on cell surface markers.

18 Apr 2014

LSTM researchers to conduct extensive research on HIV and schistosomiasis coinfection in African children

Researchers from LSTM have called for more research to be carried out into HIV and schistosomiasis coinfection in children in sub-Saharan Africa.

18 Apr 2014

Research by UCI, Salk Institute points to novel therapies for minimizing stroke-induced brain damage

By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers at UC Irvine and the Salk Institute have opened the door to new therapies that may limit or prevent stroke-induced brain damage.

18 Apr 2014

Le Bonheur Children's takes aggressive steps to minimize blood loss during heart surgery

More than 20 percent of Le Bonheur Children's Hospital's open heart surgeries are now bloodless, meaning no blood or blood products given during surgery. The Memphis, Tenn., hospital's Heart Institute has been taking aggressive steps to minimize blood loss during surgery and reduce perioperative blood transfusions over the last 18 months.

18 Apr 2014

B1/Cdk1 protein which plays key role in cell division also boosts power of mitochondrial activity

An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process.

18 Apr 2014

ARCA biopharma announces genetic screening of first patient in GENETIC-AF Phase 2B/3 clinical trial

ARCA biopharma, Inc., a biopharmaceutical company developing genetically targeted therapies for cardiovascular diseases, today announced that the first patient has been genetically screened in GENETIC-AF, its Phase 2B/3 adaptive design clinical trial.

From Medtronic 18 Apr 2014

Adrenaline does not boost long-term survival rates in heart attack patients, says study

Giving patients adrenaline after they suffer a cardiac arrest outside of a hospital does not increase their prospects of surviving long-term, according to new research conducted at St. Michael's Hospital.

18 Apr 2014

Agios begins AG-348 Phase 1 study to treat PK deficiency

Agios Pharmaceuticals, Inc., a leader in the fields of cancer metabolism and inborn errors of metabolism (IEM), today announced dose administration of AG-348 in a Phase 1 study in healthy volunteers.

18 Apr 2014

New research may help scientists develop treatments or vaccines for Dengue fever

Two recent papers by a University of Colorado School of Medicine researcher and colleagues may help scientists develop treatments or vaccines for Dengue fever, West Nile virus, Yellow fever, Japanese encephalitis and other disease-causing flaviviruses.

18 Apr 2014

Deaths from viral Hepatitis B and C exceed deaths caused by HIV/AIDS

Deaths from viral Hepatitis B and C have surpassed HIV/AIDS in many countries, including Australia and in Western Europe, according to an analysis of the 2010 Global Burden of Disease study.

18 Apr 2014

Researchers identify novel vancomycin-resistant MRSA superbug in Brazil

An international research team led by Cesar A. Arias, M.D., Ph.D., at The University of Texas Health Science Center at Houston has identified a new superbug that caused a bloodstream infection in a Brazilian patient. The report appeared in the April 17 issue of The New England Journal of Medicine.

17 Apr 2014

Discovery could have far-reaching implications for diagnosis and treatment of diabetic retinopathy

Indiana University researchers have detected new early-warning signs of the potential loss of sight associated with diabetes. This discovery could have far-reaching implications for the diagnosis and treatment of diabetic retinopathy, potentially impacting the care of over 25 million Americans.

17 Apr 2014

Researchers examine effects of introducing rapid diagnostic tests for malaria in Africa

Researchers from the Cochrane Infectious Diseases Group conducted a review of the effects of introducing rapid diagnostic tests (RDTs) for diagnosing malaria in primary healthcare settings in Africa where laboratory services are unavailable.

17 Apr 2014

Blood News and Research

Genmab/GSK receive FDA sBLA approval for Arzerra in combination with chlorambucil for treatment of CLL

EcoHealth Alliance examines the origins of Ebola virus outbreaks

Study sheds light on tiny environments that stem cells occupy in animal bodies

Study suggests that improving newborns' bacterial environment could fend off infections

Researchers reveal connection between Down syndrome and acute lymphoblastic leukemia

New device uses space-tested concept of capillary flow to diagnose infectious diseases

Three Johns Hopkins researchers awarded grants for work on potential treatments for diabetes

Researchers discover new marker derived from human umbilical cord blood

LSTM researchers to conduct extensive research on HIV and schistosomiasis coinfection in African children

Research by UCI, Salk Institute points to novel therapies for minimizing stroke-induced brain damage

Le Bonheur Children's takes aggressive steps to minimize blood loss during heart surgery

B1/Cdk1 protein which plays key role in cell division also boosts power of mitochondrial activity

ARCA biopharma announces genetic screening of first patient in GENETIC-AF Phase 2B/3 clinical trial

Adrenaline does not boost long-term survival rates in heart attack patients, says study

Agios begins AG-348 Phase 1 study to treat PK deficiency

New research may help scientists develop treatments or vaccines for Dengue fever

Deaths from viral Hepatitis B and C exceed deaths caused by HIV/AIDS

Researchers identify novel vancomycin-resistant MRSA superbug in Brazil

Discovery could have far-reaching implications for diagnosis and treatment of diabetic retinopathy

Researchers examine effects of introducing rapid diagnostic tests for malaria in Africa

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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