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Uncovering the hidden architecture of the genome in three dimensions

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this oversimplification undersells the significance of the genome's 3D structure.

12 Jul 2025

Exploring the roles of orphan nuclear receptors in MASLD pathogenesis

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting approximately 30% of the global population, represents a spectrum of liver disorders ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis.

12 Jul 2025

Osteoblast estrogen receptor signaling found essential for bone integrity

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects bone health.

12 Jul 2025

Teclistamab shows promising results in heavily pretreated multiple myeloma

Teclistamab-cqyv (Tecvayli) led to clinically meaningful responses in patients with heavily pretreated multiple myeloma who would have been ineligible for the MajesTEC-1 trial, and identified a novel factor independently associated with outcomes.

12 Jul 2025

Scientists identify key role of T-bet in flu memory B cells

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the immune system, and immune cells produce a potentially lifesaving antibody against the virus. Antigen in, antibody out.

11 Jul 2025

More than 200 types of misfolded proteins could be associated with age-related cognitive decline

For decades, the story of Alzheimer's research has been dominated by a battle between A-beta and tau amyloids, both of which can kill neurons and impact the brain's ability to function.

11 Jul 2025

Scientists uncover key role of cypin in strengthening brain cell connections

Scientists have discovered how a key protein helps maintain strong connections between brain cells that are crucial for learning and memory.

11 Jul 2025

Erin Schuman wins 2026 HFSP Nakasone Award for neuroscience breakthrough

The International Human Frontier Science Program Organization (HFSPO) is pleased to award the 2026 HFSP Nakasone Award to Erin Schuman for her breakthrough related to the function and plasticity of neuronal synapses, their mRNA triggered function, and change during memory formation.

11 Jul 2025

Egr-1 gene identified as crucial regulator of regulatory T cells in multiple sclerosis

Autoimmune diseases, such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA), affect millions of people worldwide.

11 Jul 2025

Researchers develop novel engineered extracellular matrix to improve cartilage repair

Recently, a research team from Chongqing Medical University, led by Prof. Wei Huang, Dr. Wei Bao, and Dr. Yiting Lei, has successfully developed a novel engineered extracellular matrix (eECM) to address the challenge of cartilage repair.

11 Jul 2025

Monoclonal antibody delivered through the nose blocks hay fever in mice

Approximately 40% of the European population are allergic to pollen, and their symptoms cause an estimated loss of 100 million school- and workdays every year.

11 Jul 2025

Explainable AI helps decode the substrate specificity of γ-secretase enzyme

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research.

11 Jul 2025

New discovery uncovers hidden drivers of DNA transcription errors

Every living cell must interpret its genetic code - a sequence of chemical letters that governs countless cellular functions.

11 Jul 2025

Researchers create over 400 types of nerve cells from stem cells

Nerve cells are not just nerve cells. Depending on how finely we distinguish, there are several hundred to several thousand different types of nerve cell in the human brain according to the latest calculations.

11 Jul 2025

New device offers breakthrough for safe drug delivery into the brain

A new device combining ultrasound and advanced imaging to provide crucial information for the safe delivery of drugs into the brain has been developed by University of Queensland researchers.

11 Jul 2025

Introducing the iQue® 5 HTS Platform: empowering scientists with unbeatable speed and flexibility for high throughput screening by cytometry

The life science group Sartorius launches the new iQue® 5 High-Throughput Screening (HTS) Cytometer, transforming workflows with next-level flexibility and comprehensive analysis at unbeatable speeds. Building on core iQue® strengths as the market leading solution for HTS applications, the iQue® 5 expands experimental range with up to 27 channels (25 color options) and flexible workflows in 96- and 384-well formats.

From Sartorius 11 Jul 2025

Insecticide exposure could impair mental function in older adults

The study investigates the link between pesticide exposure and cognitive impairment in older adults, suggesting a need for improved prevention strategies.

11 Jul 2025

Hydrogels could be key to safer, smarter cancer drug delivery

Hydrogels could revolutionize cancer treatment by facilitating targeted drug delivery, reducing adverse effects, and enhancing therapeutic effectiveness.

11 Jul 2025

Weekly injectable drug offers hope for Parkinson's patients

A new weekly injectable drug could transform the lives of more than eight million people living with Parkinson's disease, potentially replacing the need for multiple daily tablets.

11 Jul 2025

Mitochondria and peroxisomes work together to defend against cell damage

An international team led by researchers at The Hospital for Sick Children (SickKids), Princess Margaret Cancer Centre, Dalhousie University, the University of Exeter (UK) and the Medical University of Vienna (Austria) has uncovered a surprising way compartments within cells work together to defend themselves against oxidative stress, a finding that could shift how we understand age-associated conditions such as diabetes and neurodegenerative diseases.

10 Jul 2025