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Study offers clearer explanation of the role of FOX01 molecule in wound-healing process

Skin provides a first line of defense against viruses, bacteria and parasites that might otherwise make people ill. When an injury breaks that barrier, a systematic chain of molecular signaling launches to close the wound and re-establish the skin's layer of protection.

16 Nov 2013

Collaborative initiative set up to create precision medicine treatment pathways for advanced cancers

The Joint Center for Cancer Precision Medicine, a collaborative initiative among Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston Children's Hospital, and the Broad Institute of MIT and Harvard, has been established to create "precision medicine treatment pathways" for patients with advanced cancers and to speed the development of personalized therapies.

16 Nov 2013

Bleach solution could provide new way to treat skin damage

Processes that age and damage skin are impeded by dilute bleach solution, according to a new study by researchers at the Stanford University School of Medicine.

16 Nov 2013

Study suggests novel approach for treatment of advanced metastatic prostate cancers

New study suggests that selective blockade of CRM1-dependent nuclear export represents a completely novel, tumour metastasis-selective approach for the treatment of advanced metastatic prostate cancers.

16 Nov 2013

MGH investigators identify molecule that plays key role in the breakdown of kidney filter

One of the most devastating side effects of diabetes is kidney failure, and one of the earliest signs of kidney damage is a disruption of the organ's filtering capacity. Diabetes patients who develop kidney failure must go on dialysis, seriously limiting their quality of life and placing them at significantly increased risk of death. The incidence of kidney disease is increasing with rising rates of obesity-associated type 2 diabetes, but very little progress has been made towards protecting the kidney's filter barrier during the past 50 years.

16 Nov 2013

GO drug may improve outcome of bone marrow transplantation for select pediatric leukemia patients

Combining the drug gemtuzumab ozogamicin with conventional chemotherapy may improve the outcome of bone marrow transplantation for some children battling high-risk acute myeloid leukemia, according to a study led by St. Jude Children's Research Hospital. The results appear in the current edition of the journal Cancer.

16 Nov 2013

Diplomat selected as provider of IMBRUVICA capsules for MCL treatment

Diplomat, the country's largest independent specialty pharmacy, announced today it is one of five specialty pharmacies selected as a provider of IMBRUVICA (ibrutinib) capsules, approved Nov. 13 by the U.S. Food and Drug Administration for the treatment of Mantle Cell Lymphoma.

16 Nov 2013

Research could refine next generation of drugs to help treat dementia

A £1.1 million grant to understand how one of the brain's key neurotransmitters called 'acetylcholine' influences brain activity has been awarded to University of Bristol researchers. The Wellcome Trust award will help scientists understand more precisely how the release of acetylcholine is changing brain cell activity to influence memory and cognition.

15 Nov 2013

WuXi PharmaTech subsidiary enters into supply arrangement with Pharmacyclics

WuXi PharmaTech, a leading pharmaceutical, biotechnology and medical device research and development outsourcing company with operations in China and the United States, today announced that its wholly owned subsidiary Shanghai SynTheAll Pharmaceutical Co., Ltd., has entered into a supply arrangement with Pharmacyclics, Inc.

15 Nov 2013

Researchers identify gene responsible for Warburg Micro syndrome

A collaborative team of researchers led by researchers at the Medical College of Wisconsin and the University of Edinburgh has identified a gene responsible for Warburg Micro syndrome, a rare genetic disease characterized by eye, brain and endocrine abnormalities. Patients with Warburg Micro syndrome are severely physically and mentally challenged, unable to learn how to walk or speak and become blind and paralyzed from an early age.

15 Nov 2013

Researchers use new approach to parse roles of key mutated protein that causes familial AD

Researchers at the University of California, San Diego School of Medicine have used genetic engineering of human induced pluripotent stem cells to specifically and precisely parse the roles of a key mutated protein in causing familial Alzheimer's disease, discovering that simple loss-of-function does not contribute to the inherited form of the neurodegenerative disorder.

15 Nov 2013

Research sheds light on how protein keeps people organized by promoting orderly skeletal growth

Most people think that their planners or their iPhones keep them organized, when proteins such as liver kinase b1 (Lkb1) actually have a lot more to do with it. New research from postdoctoral fellow Lick Lai in the lab of USC scientist Andy McMahon published in Proceedings of the National Academy of Sciences (PNAS) sheds light on how this important protein keeps people organized on a basic level by promoting orderly skeletal growth and preventing skeletal tumors.

15 Nov 2013

Scientists discover new drug mechanism to reduce risk of infections

Scientists at A*STAR's Singapore Immunology Network (SIgN) have discovered the exact mode of action by plerixafor, a drug commonly prescribed to stimulate immune responses in patients suffering from neutropenia, which causes them to become prone to oral, skin, genital infections and in worst cases, a fatal whole-body infection.

15 Nov 2013

Copper intake via food and water can accelerate growth of tumors

Copper imbalances have been associated with a number of pathological conditions, including cancer. Publishing in PNAS scientists at EPFL have found that copper in drinking water - given at the maximum levels permitted in public water supplies - accelerated the growth of tumors in mice. On the other hand, reducing copper levels reduced tumor growth.

15 Nov 2013

Lower doses of antimalarial drug effective in reducing malaria transmission

Lower doses of the antimalarial drug primaquine are as effective as higher doses in reducing malaria transmission, according to a study published today in Lancet Infectious Diseases by London School of Hygiene & Tropical Medicine researchers.

15 Nov 2013

Researchers exploit power of evolution to create new drug for use against heart disease

An international team of researchers led by the University of Leicester has "harnessed the power of evolution" to create a new drug for possible use against heart disease, inflammation and other illnesses.

15 Nov 2013

Small molecule compound shows significant success in controlling polyomaviruses

A team of scientists reports that a small molecule compound showed significant success in controlling the infectivity and spread of three polyomaviruses in human cell cultures. To date there has been no medicine approved to treat such viruses, which prey on transplant recipients, people with HIV, and others whose immune systems have been weakened.

15 Nov 2013

Identifying 'sensome' of microglia could improve treatments for neurodegenerative disorders

Massachusetts General Hospital investigators have used a new sequencing method to identify a group of genes used by the brain's immune cells - called microglia - to sense pathogenic organisms, toxins or damaged cells that require their response.

15 Nov 2013

Annexin A5 protein may have therapeutic potential for treatment of sepsis

Sepsis is the leading cause of in-hospital death and there is no specific treatment for it. Now, research led by Dr. Qingping Feng of Western University (London, Canada) suggests a protein called recombinant human annexin A5 may have therapeutic potential for the treatment of this disease. The paper is published in advance, online in Critical Care Medicine.

15 Nov 2013

FDA approves ibrutinib for treatment of mantle cell lymphoma

Today's U.S. Food and Drug Administration approval of ibrutinib to treat patients with mantle cell lymphoma is a significant advance for patients with this blood cancer. It was approved as a single agent for treatment of patients with MCL who have received at least one prior therapy.

14 Nov 2013

B Cell News and Research

Study offers clearer explanation of the role of FOX01 molecule in wound-healing process

Collaborative initiative set up to create precision medicine treatment pathways for advanced cancers

Bleach solution could provide new way to treat skin damage

Study suggests novel approach for treatment of advanced metastatic prostate cancers

MGH investigators identify molecule that plays key role in the breakdown of kidney filter

GO drug may improve outcome of bone marrow transplantation for select pediatric leukemia patients

Diplomat selected as provider of IMBRUVICA capsules for MCL treatment

Research could refine next generation of drugs to help treat dementia

WuXi PharmaTech subsidiary enters into supply arrangement with Pharmacyclics

Researchers identify gene responsible for Warburg Micro syndrome

Researchers use new approach to parse roles of key mutated protein that causes familial AD

Research sheds light on how protein keeps people organized by promoting orderly skeletal growth

Scientists discover new drug mechanism to reduce risk of infections

Copper intake via food and water can accelerate growth of tumors

Lower doses of antimalarial drug effective in reducing malaria transmission

Researchers exploit power of evolution to create new drug for use against heart disease

Small molecule compound shows significant success in controlling polyomaviruses

Identifying 'sensome' of microglia could improve treatments for neurodegenerative disorders

Annexin A5 protein may have therapeutic potential for treatment of sepsis

FDA approves ibrutinib for treatment of mantle cell lymphoma

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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