Protein C News and Research

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Pathogens use previously undescribed mechanism to sabotage host immune system

New research identifies a previously unknown enzymatic mechanism that subverts the early host immune response and promotes pathogenicity by manipulating a common signaling pathway in host cells.

10 Dec 2007

Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed

During muscle regeneration, which is a natural response to injury and disease, environmental cues cause adult muscle stem cells (satellite cells) to shift from dormancy to actively building new muscle tissue.

10 Dec 2007

Nilotinib and Dasatinib show promise as therapy for chronic myelogenous leukemia

Two drugs approved for use as second line therapy for chronic myelogenous leukemia are showing promising results as frontline therapy for newly diagnosed patients in two clinical trials, research teams led by scientists at The University of Texas M. D. Anderson Cancer Center report at the 49th annual meeting of the American Society of Hematology.

10 Dec 2007

Researchers photograph cystic fibrosis protein interaction

New microscopic pictures show the first-ever physical evidence of interaction between two proteins involved in Cystic Fibrosis (CF) disease.

10 Dec 2007

Complete response with oblimersen combination improves survival of CLL patients

Relapsed chronic lymphocytic leukemia (CLL) patients who had a complete response to combination therapy that included the drug oblimersen survived significantly longer than patients treated with chemotherapy alone, a team led by researchers at The University of Texas M. D. Anderson Cancer Center reports at the 49th Annual Meeting of the American Society of Hematology.

10 Dec 2007

Chikungunya virus spreads to new vectors

Researchers at the University of Texas Medical Branch have discovered how a key protein switch allows Chikungunya Virus (CHIKV) to spread to new vectors.

10 Dec 2007

Antioxidant cocktail shows good results in fight against prostate cancer

Prostate cancer trials undertaken at the University of Sydney have provided exciting results with reductions of up to 25 per cent of tumour growth in mouse models.

9 Dec 2007

Discovery of potential "getting drunk" gene

A variant of a gene involved in communication among brain cells has a direct influence on alcohol consumption in mice, according to a new study by scientists supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), and the U.S. Army.

5 Dec 2007

Pheromones identified that trigger aggression between male mice

A family of proteins commonly found in mouse urine is able to trigger fighting between male mice, a study in the Dec. 6, 2007, issue of Nature has found.

5 Dec 2007

Missing brain protein may be one of the culprits behind autism and other brain disorders

The protein helps synapses develop. Synapses--through which neurons communicate with one other-underlie our ability to learn and remember. Now Li-Huei Tsai, Picower Professor of Neuroscience at MIT, has uncovered an enzyme that is key to that protein's activity.

5 Dec 2007

Implanting embryonic cardiac cells prevents arrhythmias

When researchers at Cornell, the University of Bonn and the University of Pittsburgh transplanted living embryonic heart cells into cardiac tissue of mice that had suffered heart attacks, the mice became resistant to cardiac arrhythmias, thereby avoiding one of the most dangerous and fatal consequences of heart attacks.

5 Dec 2007

Cognitive 'fog' of normal aging linked to brain system disruption

Comparisons of the brains of young and old people have revealed that normal aging may cause cognitive decline due to deterioration of the connections among large-scale brain systems.

5 Dec 2007

Scientists characterize Alzheimer's neurotoxin structure - potential new treatment approaches

Amyloid plaques, the hallmark of Alzheimer's disease, are clumps of fiber-like misfolded proteins which many experts think cause this devastating neurodegenerative disease.

4 Dec 2007

Positive results from trial of investigational anti-epilepsy drug Brivaracetam

UCB has announced data demonstrating that anti-epileptic drug (AED) brivaracetam, with the proposed trade name Rikelta, administered as an adjunctive treatment in adults with refractory epilepsy with partial onset seizures, significantly reduced seizure frequency and had a side-effect profile comparable to placebo.

4 Dec 2007

Re-engineered Gleevec reduces heart risks

Using a new bottom-up approach for rational drug design, researchers at Rice University and the University of Texas M. D. Anderson Cancer Center have reengineered the powerful anticancer drug imatinib - best known by its brand name Gleevec - to more specifically target one type of cancer while potentially curbing a rare life-threatening cardiotoxic side effect.

4 Dec 2007

sLRP1-alpha provides relief from neuropathic pain

Injury to peripheral nerves (the causes of which include shingles, HIV-AIDS, toxins, alcoholism, repetitive motion disorders, surgery, and cancer) causes neuropathic pain, which differs from ordinary pain and is usually perceived as a steady burning, pins and needles, electric shock sensations, and/or tickling.

4 Dec 2007