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Study: Sleep allows brain to flush out damaging molecules linked with neurodegeneration

A good night's rest may literally clear the mind. Using mice, researchers showed for the first time that the space between brain cells may increase during sleep, allowing the brain to flush out toxins that build up during waking hours.

18 Oct 2013

CHOP offers new software toolkit to help researchers wrangle data

Biomedical researchers often confront large quantities of information that may be amassed in many forms: vital signs, blood cell counts, lengthy DNA sequences, bar graphs, MRIs, patient demographics, and so much more. How do researchers assemble, access and analyze all that data without having to become specialized database technicians themselves?

18 Oct 2013

Study shows how two miRNAs regulate FOXP2 gene implicated in speech, language impairments

A study led by Xiaoching Li, PhD, at the LSU Health Sciences Center New Orleans Neuroscience Center of Excellence, has shown for the first time how two tiny molecules regulate a gene implicated in speech and language impairments as well as autism disorders, and that social context of vocal behavior governs their function.

18 Oct 2013

Combination of heat, doxorubicin drug and nanotech system may improve ovarian cancer treatment

The combination of heat, chemotherapeutic drugs and an innovative delivery system based on nanotechnology may significantly improve the treatment of ovarian cancer while reducing side effects from toxic drugs, researchers at Oregon State University report in a new study.

18 Oct 2013

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

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17 Oct 2013

Neurons strengthen their synapses to remain active after loss of input

The brain is an extremely adaptable organ - but it is also quite conservative. That's in short, what scientists from the Max Planck Institute of Neurobiology in Martinsried and their colleagues from the Friedrich Miescher Institute in Basel and the Ruhr-Universit-t Bochum were now able to show.

17 Oct 2013

Proteins in CSF predict cognitive impairment before onset of disease

Johns Hopkins researchers say that by measuring levels of certain proteins in cerebrospinal fluid (CSF), they can predict when people will develop the cognitive impairment associated with Alzheimer's disease years before the first symptoms of memory loss appear.

17 Oct 2013

Researchers develop new microfluidic device that could speed monitoring of bacterial infections

There are good bacteria and there are bad bacteria -- and sometimes both coexist within the same species. Take, for instance, Pseudomonas aeruginosa, a microbe common in soil and water.

17 Oct 2013

New method to display viral DNA in host cells at single-molecule resolution

The medical, humanitarian and economical impact of viral diseases is devastating to humans and livestock. There are no adequate therapies available against most viral diseases, largely because the mechanisms by which viruses infect cells are poorly known.

17 Oct 2013

Nintedanib drug to treat NSCLC is submitted for approval from European Medicines Agency

Boehringer Ingelheim announced the submission of a Marketing Authorisation Application to the European Medicines Agency for the approval of its oral triple angiokinase inhibitor nintedanib, in combination with docetaxel, for the treatment of patients with locally advanced, metastatic or recurrent non-small cell lung cancer (NSCLC) of adenocarcinoma tumour histology after first line chemotherapy.

17 Oct 2013

Researchers find novel drug target for anaplastic thyroid carcinomas

Anaplastic thyroid carcinomas are aggressive tumors that do not respond to traditional radio- or chemotherapeutic agents, and there currently is no cure or effective treatment available. Median survival from diagnosis is 5 months, and although ATC accounts for only 1.7% of all thyroid cancers in the U.S., it is responsible for a large proportion of thyroid cancer-related deaths.

17 Oct 2013

Scientists identify 127 mutated genes that appear to drive development of tumors in the body

Examining 12 major types of cancer, scientists at Washington University School of Medicine in St. Louis have identified 127 repeatedly mutated genes that appear to drive the development and progression of a range of tumors in the body. The discovery sets the stage for devising new diagnostic tools and more personalized cancer treatments.

17 Oct 2013

Research in mouse whiskers reveals signal pathway from touch neuron to brain

Human fingertips have several types of sensory neurons that are responsible for relaying touch signals to the central nervous system. Scientists have long believed these neurons followed a linear path to the brain with a "labeled-lines" structure.

17 Oct 2013

Research findings point the way to new class of antibiotics for skin and heart infections

Researchers at NYU Langone Medical Center have discovered a new mechanism by which the deadly Staphylococcus aureus bacteria attack and kill off immune cells. Their findings, published today in the journal Cell Host & Microbe, explain a critical survival tactic of a pathogen that causes more skin and heart infections than any other microbe, and kills more than 100,000 Americans every year.

17 Oct 2013

Light pulses stimulate designer peptides to trigger death pathway in cancerous cells

Researchers at Cardiff University have created a peptide (a small piece of protein), linked to a light-responsive dye, capable of switching 'on' death pathways in cancer cells. The peptide remains inactive until exposed to external light pulses which convert it into a cell death signal.

17 Oct 2013

Imaxio Sells Genomics Division To Hybrigenics

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16 Oct 2013

Trovagene launches pharmaceutical alliance to monitor lung cancer patients' EGFR mutational status

Trovagene, Inc., a developer of cell-free molecular diagnostics, today announced that it will collaborate with a pharmaceutical company to evaluate Trovagene's proprietary, urine-based, cell-free DNA technology for the detection of certain epidermal growth factor receptor mutations associated with lung cancer.

16 Oct 2013

CU researchers explore why maximum heart rate decreases with age

Researchers at the University of Colorado have new insight into the age-old question of why maximum heart rate decreases with age. This decrease in maxHR not only limits the performance of aging athletes but it is also a leading cause for nursing home admittance for otherwise-healthy elderly individuals who no longer have the physical capacity required for independent living.

16 Oct 2013

Study aims to identify age-related changes in metabolic pathways

Have you ever wondered why young children can eat bags of Halloween candy and feel fine the next day - compared to adults who experience all sorts of agony following the same junk food binge? Evolution and a gene called Foxo may be to blame. Working in fruit flies, scientists at the Buck Institute have identified a mechanism that helps the flies adapt to changes in diet when they're young; they've discovered that same mechanism gets misregulated as the flies age, disrupting metabolic homeostasis, or balance.

16 Oct 2013

Ticagrelor drug may reduce risk of dying following heart attack

Scientists from the University of Sheffield have discovered ground breaking clues as to how the pioneering heart drug ticagrelor might reduce the risk of dying following a heart attack, in comparison to previous standard treatments.

16 Oct 2013

B Cell News and Research

Study: Sleep allows brain to flush out damaging molecules linked with neurodegeneration

CHOP offers new software toolkit to help researchers wrangle data

Study shows how two miRNAs regulate FOXP2 gene implicated in speech, language impairments

Combination of heat, doxorubicin drug and nanotech system may improve ovarian cancer treatment

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

Neurons strengthen their synapses to remain active after loss of input

Proteins in CSF predict cognitive impairment before onset of disease

Researchers develop new microfluidic device that could speed monitoring of bacterial infections

New method to display viral DNA in host cells at single-molecule resolution

Nintedanib drug to treat NSCLC is submitted for approval from European Medicines Agency

Researchers find novel drug target for anaplastic thyroid carcinomas

Scientists identify 127 mutated genes that appear to drive development of tumors in the body

Research in mouse whiskers reveals signal pathway from touch neuron to brain

Research findings point the way to new class of antibiotics for skin and heart infections

Light pulses stimulate designer peptides to trigger death pathway in cancerous cells

Imaxio Sells Genomics Division To Hybrigenics

Trovagene launches pharmaceutical alliance to monitor lung cancer patients' EGFR mutational status

CU researchers explore why maximum heart rate decreases with age

Study aims to identify age-related changes in metabolic pathways

Ticagrelor drug may reduce risk of dying following heart attack

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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