Antigen News and Research

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New skin test for TB infection proves safe, effective in clinical trials

A new skin test for tuberculosis infection has proven safe, easy to administer and accurate in two Phase III clinical trials, according to research presented at the ATS 2016 International Conference.

19 May 2016

Study shows expression of high-affinity TCRs linked with spontaneous control of HIV infection

A small number of patients infected by HIV spontaneously control viral replication without antiretroviral therapy, and do not develop the disease. The ability of these rare patients, known as "HIV controllers", to suppress HIV replication appears to be down to a highly effective immune response.

19 May 2016

Understanding antibody transport mechanisms in the brain

Diseases of the central nervous system (CNS), such as stroke, brain cancer, and Alzheimer's disease, are a serious threat affecting over 50 million Americans with an associated cost of over $750 billion per year, which is expected to grow significantly over the coming decades.

19 May 2016

New IsoPSA test identifies molecular structural changes in protein biomarkers to detect prostate cancer

A promising new test is detecting prostate cancer more precisely than current tests, by identifying molecular changes in the prostate specific antigen (PSA) protein, according to Cleveland Clinic research presented today at the American Urological Association annual meeting.

12 May 2016

Lawson Health scientists capture prostate cancer images using unique molecule

Scientists at Lawson Health Research Institute are the first in Canada to capture prostate cancer images using a new molecule. Known as a Prostate Specific Membrane Antigen (PSMA) probe, the new molecule is used in Positron Emissions Tomography (PET) scans.

11 May 2016

Serum biomarkers can help predict risk of IBD development and complications

Years before inflammatory bowel disease (IBD) is diagnosed and symptoms exist, biomarkers are already circulating that can help predict risk not only of disease development but also of complications, according to research published online last week, which will also appear in the June 15th print issue of Alimentary Pharmacology & Therapeutics.

6 May 2016

T cell gives precise mechanical tugs to detect friends and foes

T cells, the security guards of the immune system, use a kind of mechanical "handshake" to test whether a cell they encounter is a friend or foe, a new study finds.

6 May 2016

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

University of Alabama at Birmingham researchers report the first documentation that suppressing a key cell-signaling pathway in a rat model of Parkinson's disease reduces pathogenesis. Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson's.

4 May 2016

NSCLC MAGE-A3 immunotherapy development halted

Disease-free survival is not prolonged with adjuvant MAGE-A3 immunotherapy in patients with surgically resected non-small-cell lung cancer, according to a placebo-controlled trial.

4 May 2016

LJI study could provide important target for autoimmune disease interventions

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensable for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones.

3 May 2016

New model can increase active surveillance for low-risk prostate cancer patients

Urologists at University of California, San Diego School of Medicine and Genesis Healthcare Partners have tested a new model of care for patients with low-risk prostate cancer. The evidence-based approach uses best practices to appropriately select and follow patients to avoid disease overtreatment. Results of the three-year study are now published online in the journal of Urology.

28 Apr 2016

Experimental therapy has over 90% remission rate for advanced leukemia patients

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells (disease-fighting immune cells) were genetically engineered to fight their cancers.

28 Apr 2016

HBcrAg may predict HCC development

Research suggests a role for hepatitis B core-related antigen in the prediction of hepatocellular carcinoma development in nucleos(t)ide analogue treatment-naïve patients with chronic hepatitis B virus infection.

27 Apr 2016

Study highlights potential emergence of new swine flu strains

The wide diversity of flu in pigs across multiple continents, mostly introduced from humans, highlights the significant potential of new swine flu strains emerging, according to a study to be published in eLife.

26 Apr 2016

Naturally-occurring molecule can cause immune cells to go into hyperactive state

Researchers at Boston Children's Hospital report that a fatty chemical naturally found in damaged tissues can induce an unexpected kind of immune response, causing immune cells to go into a "hyperactive" state that is highly effective at rallying infection-fighting T-cells. The findings, published online by Science on April 21, could enhance vaccines and make them much more effective.

22 Apr 2016

CWRU scientists develop computational tools to quantify effects of prostate cancer laser ablation

Prostate cancers are either low-grade, low-risk forms that may be monitored but otherwise untreated. Or they're serious enough to require surgery and radiation.

20 Apr 2016

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests. Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection.

20 Apr 2016

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

In a clinical trial of the immunotherapy drug pembrolizumab, half of 25 patients with a rare type of virus-linked skin cancer called Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long, on average, than with conventional chemotherapy.

20 Apr 2016

Researchers find mechanism behind pancreatic cancer cells' resistance to certain drugs

Pancreatic cancer is on track to become the second leading cause of cancer-related deaths by 2020. These statistics are due, in part, to pancreatic cancer's resistance to most targeted cancer therapies. Working with pancreatic cancer cells, researchers have now found a mechanism that could be responsible for the cancer's resistance to at least one targeted approach.

19 Apr 2016

Penn researchers report results of CAR therapy trial in brain cancer patients

Immune cells engineered to seek out and attack a type of deadly brain cancer known as glioblastoma (GBM) were found to have an acceptable safety profile and successfully migrate to and infiltrate tumors, researchers from Penn Medicine and Harvard University reported at the AACR Annual Meeting 2016.

19 Apr 2016

Antigen News and Research

New skin test for TB infection proves safe, effective in clinical trials

Study shows expression of high-affinity TCRs linked with spontaneous control of HIV infection

Understanding antibody transport mechanisms in the brain

New IsoPSA test identifies molecular structural changes in protein biomarkers to detect prostate cancer

Lawson Health scientists capture prostate cancer images using unique molecule

Serum biomarkers can help predict risk of IBD development and complications

T cell gives precise mechanical tugs to detect friends and foes

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

NSCLC MAGE-A3 immunotherapy development halted

LJI study could provide important target for autoimmune disease interventions

New model can increase active surveillance for low-risk prostate cancer patients

Experimental therapy has over 90% remission rate for advanced leukemia patients

HBcrAg may predict HCC development

Study highlights potential emergence of new swine flu strains

Naturally-occurring molecule can cause immune cells to go into hyperactive state

CWRU scientists develop computational tools to quantify effects of prostate cancer laser ablation

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

Researchers find mechanism behind pancreatic cancer cells' resistance to certain drugs

Penn researchers report results of CAR therapy trial in brain cancer patients

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