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New research shows how fat controls energy levels in the brain

An enzyme secreted by the body's fat tissue controls energy levels in the brain, according to new research at Washington University School of Medicine in St. Louis. The findings, in mice, underscore a role for the body's fat tissue in controlling the brain's response to food scarcity, and suggest there is an optimal amount of body fat for maximizing health and longevity.

24 Apr 2015

Mitotech reports positive results from SkQ1 Phase II trial in patients with moderate to severe dry eye syndrome

Mitotech S.A, a Luxembourg-based clinical-stage biotechnology company developing novel antioxidant molecules targeting mitochondria, today announced that it has achieved significant positive results in its U.S. Phase II clinical trial of SkQ1 compound in patients with moderate to severe dry eye syndrome.

24 Apr 2015

Mitotech reports positive results from SkQ1 Phase II trial in patients with moderate to severe dry eye syndrome

24 Apr 2015

Remogliflozin etabonate: A potential treatment option for management of NASH and NAFLD

Data presented today at The International Liver Congress 2015 demonstrates that remogliflozin etabonate, an investigational drug in type 2 diabetes, is a potential treatment option for the management of patients with non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD).

23 Apr 2015

Capsaicin has beneficial effects on liver damage, study reveals

Results revealed today at the International Liver Congress 2015 show that the daily consumption of capsaicin, the active compound of chilli peppers, was found to have beneficial effects on liver damage.

23 Apr 2015

Scientists report novel approach to reverse Parkinson's-like symptoms in rats

As baby boomers age, the number of people diagnosed with Parkinson's disease is expected to increase. Patients who develop this disease usually start experiencing symptoms around age 60 or older. Currently, there's no cure, but scientists are reporting a novel approach that reversed Parkinson's-like symptoms in rats.

23 Apr 2015

Chemists working to develop 'greener' processes for discovering, developing medicines

Chemists funded by NIH's National Institute of General Medical Sciences are working to develop "greener" processes for discovering, developing and manufacturing medicines and other molecules with therapeutic potential, as well as compounds used in biomedical research.

22 Apr 2015

Botanical formula improves effect of tamoxifen drug in ER+ human breast cancer

Researchers at the Cancer Research Laboratory, Methodist Research Institute, Indiana University Health found that a botanical formula for breast health inhibited the growth of estrogen receptor-positive (ER+) human breast cancer cells. More importantly, the researchers also found that the formula enhanced the anti-cancer benefits of the drug tamoxifen in the treatment of breast cancer.

22 Apr 2015

Honokiol extract holds promise as adjunct treatment for bladder and kidney cancers

The botanical extract honokiol, a biologically active molecule isolated from the bark of Magnolia spp., holds promise as an adjunct treatment for aggressive bladder and kidney cancers, as reported in two new studies. New research on honokiol in bladder cancer was presented at the American Association for Cancer Research Annual Meeting 2015.

22 Apr 2015

BioReliance inks non-exclusive license agreement with QTS for proprietary B-CLEAR technology

BioReliance, Sigma-Aldrich Corporation's biologics and early-development services business under SAFC Commercial, is pleased to announce a non-exclusive license agreement with Qualyst Transporter Solutions for its proprietary B-CLEAR technology.

21 Apr 2015

BrainStorm presents positive results from NurOwn phase 2a study in ALS at AAN annual meeting

BrainStorm Cell Therapeutics Inc., a leading developer of adult stem cell technologies for neurodegenerative diseases, is presenting results from its phase 2a study of NurOwn in amyotrophic lateral sclerosis (ALS) at a poster session today at the American Academy of Neurology annual meeting, taking place in Washington D.C.

21 Apr 2015

Global changes in cancer cells' epigenome may determine disease progression

Genomic studies have illuminated the ways in which malfunctioning genes can drive cancer growth while stunting the therapeutic effects of chemotherapy and other treatments. But new findings from Weill Cornell Medical College investigators indicate that these genes are only partly to blame for why treatment that was at one point effective ultimately fails for about 40 percent of patients diagnosed with the most common form of non-Hodgkin Lymphoma.

21 Apr 2015

Novel treatment strategy targets treatment-resistant CML

Researchers have shown that the coiled-coil mimetic CCmut3 can inhibit cell growth and promote apoptosis in cell lines expressing BCR–ABL1, including those resistant to tyrosine kinase inhibitors.

20 Apr 2015

CiRA, Takeda collaborate to develop clinical applications of iPS cells

Center for iPS Cell Research Application of Kyoto University and Takeda Pharmaceutical Company Limited announced today that they will work together to develop clinical applications of induced pluripotent stem cells in areas such as heart failure, diabetes mellitus, neurological disorders and cancer immunotherapy.

17 Apr 2015

Electronic micropump combined with anticonvulsant drug may treat brain diseases

Many potentially efficient drugs have been created to treat neurological disorders, but they cannot be used in practice. Typically, for a condition such as epilepsy, it is essential to act at exactly the right time and place in the brain.

16 Apr 2015

New study shows nicotine exposure promotes alcohol dependence

Why do smokers have a five to ten times greater risk of developing alcohol dependence than nonsmokers? Do smokers have a greater tendency toward addiction in general or does nicotine somehow reinforce alcohol consumption? Now, a study led by scientists at The Scripps Research Institute helps provide insight into these questions, showing that, in rat models, nicotine exposure actually promotes alcohol dependence.

16 Apr 2015

Ancient natural compound can protect the heart from hypertrophy

A natural compound derived from the bark of the magnolia tree, can protect the heart from hypertrophy, a thickening of cardiac muscle often caused by chronic high blood pressure that can lead to heart failure, researchers report in the April 14 issue of the online journal Nature Communications.

15 Apr 2015

Optibrium to integrate ChemAxon's Plexus with StarDrop software platform

Optibrium and ChemAxon, developers of software and cheminformatics solutions for drug discovery, today announced the results of a collaboration to integrate ChemAxon's Plexus with Optibrium's StarDrop software suite. The integration of these platforms further enables researchers to develop strategies for efficient, high quality compound library design.

15 Apr 2015

TSRI Scientists find that nicotine use increases compulsive alcohol consumption

15 Apr 2015

iCardiac launches industry-first full risk-sharing program for cardiac safety studies

iCardiac Technologies, a market and scientific leader in the conduct of cardiac safety assessments, announced today that it has launched the industry’s first full risk-sharing program for Thorough QT studies. Leveraging its innovative High Precision QT™ methodology for analyzing ECG waveforms, iCardiac’s program guarantees to sponsors that one of two desirable outcomes will be achieved.

14 Apr 2015

Compound News and Research

New research shows how fat controls energy levels in the brain

Mitotech reports positive results from SkQ1 Phase II trial in patients with moderate to severe dry eye syndrome

Mitotech reports positive results from SkQ1 Phase II trial in patients with moderate to severe dry eye syndrome

Remogliflozin etabonate: A potential treatment option for management of NASH and NAFLD

Capsaicin has beneficial effects on liver damage, study reveals

Scientists report novel approach to reverse Parkinson's-like symptoms in rats

Chemists working to develop 'greener' processes for discovering, developing medicines

Botanical formula improves effect of tamoxifen drug in ER+ human breast cancer

Honokiol extract holds promise as adjunct treatment for bladder and kidney cancers

BioReliance inks non-exclusive license agreement with QTS for proprietary B-CLEAR technology

BrainStorm presents positive results from NurOwn phase 2a study in ALS at AAN annual meeting

Global changes in cancer cells' epigenome may determine disease progression

Novel treatment strategy targets treatment-resistant CML

CiRA, Takeda collaborate to develop clinical applications of iPS cells

Electronic micropump combined with anticonvulsant drug may treat brain diseases

New study shows nicotine exposure promotes alcohol dependence

Ancient natural compound can protect the heart from hypertrophy

Optibrium to integrate ChemAxon's Plexus with StarDrop software platform

TSRI Scientists find that nicotine use increases compulsive alcohol consumption

iCardiac launches industry-first full risk-sharing program for cardiac safety studies

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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