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Prolong Pharmaceuticals' SANGUINATE granted FDA Orphan Drug Designation for SCD treatment

Prolong Pharmaceuticals, LLC, a biopharmaceutical company dedicated to developing products for the treatment of anemias, cancers and their debilitating comorbidities, announced today that the U.S. Food and Drug Administration has granted Orphan Drug Designation for its flagship product SANGUINATE for the treatment of Sickle Cell Disease (SCD).

8 Apr 2015

Scientists identify brain molecule that triggers schizophrenia-like behaviors, brain changes

Scientists at The Scripps Research Institute have identified a molecule in the brain that triggers schizophrenia-like behaviors, brain changes and global gene expression in an animal model. The research gives scientists new tools for someday preventing or treating psychiatric disorders such as schizophrenia, bipolar disorder and autism.

8 Apr 2015

Researchers explore influence of low-frequency magnetic fields on neurodegenerative disorders

Low-frequency alternating magnetic fields such as those generated by overhead power lines are considered a potential health risk because epidemiological studies indicate that they may aggravate, among other things, neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

8 Apr 2015

CUMC researchers identify cellular defect that could lead to potential new treatment for diabetes

A cellular defect that can impair the body's ability to handle high glucose levels and could point the way to a potential new treatment for diabetes has been identified by Columbia University Medical Center researchers.

8 Apr 2015

New study could point to potential ways to address defects in learning, memory

Just as some people seem built to run marathons and have an easier time going for miles without tiring, others are born with a knack for memorizing things, from times tables to trivia facts. These two skills—running and memorizing—are not so different as it turns out.

8 Apr 2015

Study identifies gut immune system as new, effective target for diabetes

A commonly-used drug to treat inflammatory bowel disease, such as Crohn's disease, has been shown to lower blood sugar levels in obese mice, potentially identifying the gut immune system as a new and effective target in treating diabetes in humans.

8 Apr 2015

Research finding may lead to new potential therapeutic targets for lung cancer

Lung cancer is the second most common type of cancer and the number one cause of cancer-related mortality. It is estimated that more than 158,000 people will die from lung cancer in the United States this year. Many scientists believe that targeting a type of cell called a cancer stem cell may be necessary to completely cure lung cancer.

8 Apr 2015

Experimental oligonucleotide-based drug stimulates human immune system to fight infections

An experimental single-stranded oligonucleotide-based drug, MGN1703, comprised only of natural DNA components, stimulates the human immune system to fight infections and attack cancer cells without causing the harmful side effects associated with similar compounds that also contain non-natural DNA components.

8 Apr 2015

St. Luke’s Cancer Center offers new Phase II oncolytic viral therapy clinical trial for advanced melanoma

St. Luke’s Cancer Center is a leader in offering clinical trials for patients with melanoma, the most unusual type of skin cancer and also the most deadly. Physicians such as Sanjiv Agarwala, MD, Chief of Medical Oncology and Hematology for St. Luke’s University Health Network and an internationally recognized melanoma specialist, are committed to bringing the most promising studies to the Lehigh Valley.

8 Apr 2015

Northwestern University researchers find safer way to improve surgery outcomes

A Northwestern University research team potentially has found a safer way to keep blood vessels healthy during and after surgery.

7 Apr 2015

CXCR3 molecule is key mediator of melanoma metastasis, shows research

In a unique partnership demonstrating excellence in "team science," Dartmouth investigators from Norris Cotton Cancer Center identified a role for the molecule CXCR3 (widely known to regulate the migration of immune cells) as a key mediator of melanoma metastasis.

7 Apr 2015

RNA could be a potential target for new anticancer drugs, say UC Berkeley scientists

Most of today's anticancer drugs target the DNA or proteins in tumor cells, but a new discovery by University of California, Berkeley, scientists unveils a whole new set of potential targets: the RNA intermediaries between DNA and proteins.

7 Apr 2015

Study: Key signaling pathway in B-cell lymphoma can be blocked using compounds

Cancer researchers from the University of Zurich have identified a key signaling pathway in B-cell lymphoma, a malignant type of blood cancer.

7 Apr 2015

Common cancers deform mitochondria to create conducive environment for tumor growth

In a breakthrough in the understanding of how cancer does its deadly work, researchers at the University of Virginia School of Medicine have shown that many cancers - including nearly all pancreatic cancers - enslave and deform mitochondria, the powerhouses of cells, to create an environment more conducive to tumor growth.

7 Apr 2015

Arvinas, Merck team up to create new therapeutics using protein degradation technology

Arvinas LLC, a private biotechnology company creating a new class of drugs based on protein degradation, announced a strategic collaboration with Merck, known as MSD outside of the United States and Canada, in which Arvinas' novel PROTAC technology will be used to degrade target proteins, with the goal of creating novel therapeutics.

7 Apr 2015

MGH investigators identify inflammatory molecule that plays key role in lupus

Massachusetts General Hospital (MGH) investigators have identified an inflammatory molecule that appears to play an essential role in the autoimmune disorder systemic lupus erythematosus, commonly known as lupus.

7 Apr 2015

New model can help predict how humans adapt to high- and low-altitude hypoxia

There are few times in life when one should aim for suboptimal performance, but new research at Rice University suggests scientists who study metabolism and its role in evolution should look for signs of just that.

7 Apr 2015

Study: Broken communication in brain regions appears to worsen Huntington's disease

Indiana University researchers have found that broken communication in a specific part of the brain plays a role in the involuntary physical movements that affect individuals with Huntington's disease.

7 Apr 2015

High Throughput ChIP Sequencing

Chromatrap®, a business unit of Porvair Sciences, has announced a major product launch at the European Human Genetics Conference (Glasgow, UK) and the Festival of Genomics (Boston, USA) on the 6th June 2015 and 22nd-24th June 2015 respectively

From Chromatrap® - Porvair Sciences Ltd 6 Apr 2015

Natera raises $55.5 million in funding led by Sofinnova Ventures

Natera, Inc., a leader in non-invasive genetic testing, today announced that it has raised approximately $55.5 million in funding led by Silicon Valley life sciences investment firm Sofinnova Ventures. This financing round also includes participation from Capital Research and Management, Franklin Templeton Investments, Jennison Associates, RA Capital Management, Healthcor Partners and OrbiMed Advisors.

From Natera 6 Apr 2015

Cell News and Research

Prolong Pharmaceuticals' SANGUINATE granted FDA Orphan Drug Designation for SCD treatment

Scientists identify brain molecule that triggers schizophrenia-like behaviors, brain changes

Researchers explore influence of low-frequency magnetic fields on neurodegenerative disorders

CUMC researchers identify cellular defect that could lead to potential new treatment for diabetes

New study could point to potential ways to address defects in learning, memory

Study identifies gut immune system as new, effective target for diabetes

Research finding may lead to new potential therapeutic targets for lung cancer

Experimental oligonucleotide-based drug stimulates human immune system to fight infections

St. Luke’s Cancer Center offers new Phase II oncolytic viral therapy clinical trial for advanced melanoma

Northwestern University researchers find safer way to improve surgery outcomes

CXCR3 molecule is key mediator of melanoma metastasis, shows research

RNA could be a potential target for new anticancer drugs, say UC Berkeley scientists

Study: Key signaling pathway in B-cell lymphoma can be blocked using compounds

Common cancers deform mitochondria to create conducive environment for tumor growth

Arvinas, Merck team up to create new therapeutics using protein degradation technology

MGH investigators identify inflammatory molecule that plays key role in lupus

New model can help predict how humans adapt to high- and low-altitude hypoxia

Study: Broken communication in brain regions appears to worsen Huntington's disease

High Throughput ChIP Sequencing

Natera raises $55.5 million in funding led by Sofinnova Ventures

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