Immune Response News and Research

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New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule.

3 Apr 2021

Combination of tumor cell vaccine and checkpoint therapy creates effective immune response

A personalized tumor cell vaccine strategy targeting Myc oncogenes combined with checkpoint therapy creates an effective immune response that bypasses antigen selection and immune privilege, according to a pre-clinical study for neuroblastoma and melanoma.

3 Apr 2021

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

There have been concerns that several SARS-CoV-2 variants have mutations that allow them to evade the immune system. A new study published in the Open Forum Infectious Diseases suggests otherwise. Led by Aaron AR Tobian of Johns Hopkins University School of Medicine, results showed that except for one from the B.1.351 variant, CD8+ T cells showed a broad response to all SARS-CoV-2 variants.

2 Apr 2021

Muscle strength and mass may predict hospital stay duration in COVID-19 patients

Researchers found that COVID-19 patients with good muscle strength and higher muscle mass had a shorter stay in the hospital.

2 Apr 2021

Can asymptomatic COVID-19 confer long-term immunity?

Researchers examined the antibody responses in symptomatic and asymptomatic individuals recovered from COVID-19 to see if there was a discernable difference in their humoral immune responses and long-term protection from reinfection with SARS-CoV-2.

1 Apr 2021

Researchers develop a recombinant SARS-CoV-2 receptor-binding domain trimer vaccine candidate

New research deals with the development of RBD trimer as a potent target for SARS-CoV-2 subunit vaccines. This study revealed the development of a trimeric RBD subunit vaccine candidate that could induce strong humoral and cellular immune responses in nonhuman primates (NHPs), namely, rhesus macaques.

1 Apr 2021

Temperature difference in the upper and lower respiratory tract influences SARS-CoV-2 replication

A team of researchers from the Institute for Infectious Diseases (IFIK) at the University of Bern and the Federal Institute of Virology and Immunology (IVI) have assessed virus growth and activation of the cellular defense mechanisms in the respiratory tract.

1 Apr 2021

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

An investigational vaccine designed to protect against the B.1.351 SARS-CoV-2 variant has been administered as part of a new Phase 1 clinical trial evaluating the vaccine candidate's safety and immunogenicity in adult volunteers.

31 Mar 2021

Tamper-proof temperature indicator could help monitor ideal storage conditions of mRNA vaccines

Scientists have developed vaccines for COVID-19 with record speed. The first two vaccines widely distributed in the U.S. are mRNA-based and require ultracold storage (-70 C for one and -20 C for the other).

31 Mar 2021

New mRNA COVID-19 vaccine candidate shows promise in vivo

Researchers report that a new lipid nanoparticle mRNA coronavirus disease 2019 (COVID-19) vaccine candidate protected 70% of mice expressing the human angiotensin-converting enzyme 2 (ACE2), while all the non-vaccinated mice died.

31 Mar 2021

Are marine mammals are at risk of COVID-19?

Researchers have identified a number of marine mammal species native to Italian seawaters that may be highly susceptible to the disease. Additionally, these species inhabit ocean areas where the virus may be present even after receiving sewage treatment, thus highlighting the need for strict sewage improvement plans.

31 Mar 2021

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is now established to be more likely to lead to symptomatic and serious illness in males relative to females. This may extend as far back as pregnancy, suggests a recent study.

31 Mar 2021

Infliximab may hinder the effectiveness of some COVID-19 vaccines

A new study reports reduced vaccine efficacy following the use of a single COVID-19 vaccine dose in people who are on the immunosuppressive monoclonal antibody Infliximab.

31 Mar 2021

SARS-CoV-2 inhibits the cellular response to interferon

Researchers have explored the effect of SARS-CoV-2 infection on the function of RIG-I and MDA5, and ultimately on interferon production.

31 Mar 2021

NIAID researchers identify key player in the immune response to SARS-CoV-2

When variants of SARS-CoV-2 (the virus that causes COVID-19) emerged in late 2020, concern arose that they might elude protective immune responses generated by prior infection or vaccination, potentially making re-infection more likely or vaccination less effective.

31 Mar 2021

Study finds remarkable differences in the way individuals respond to malaria

Scientists have discovered that tracking malaria as it develops in humans is a powerful way to detect how the malaria parasite causes a range of infection outcomes in its host.

31 Mar 2021

Scientists receive NIH grant to monitor COVID-19 in wastewater

Everyone poops, and now scientists are using this bodily function to develop a detailed analysis of the virus that causes COVID-19, known as SARS-CoV-2.

31 Mar 2021

Study of twins reveals differences in adaptive immunity towards SARS-CoV-2

Twins may look alike on the outside, but not so much on the inside. That's one takeaway from a new preprint study posted to the medRxiv server where Brazilian researchers observed different T-cell responses in two pairs of identical twins exposed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One twin who was reinfected with SARS-CoV-2 four months after had low recognition of CD4+ and CD8+ T-cell epitopes.

31 Mar 2021

New coronavirus variant with E484K mutation detected in Arizona

Arizona joins the ever-growing list of American states harboring a variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A study led by Efrem S. Lim of Arizona State University confirms evidence of the B.1.243.1 with an E484K mutation on the spike protein.

30 Mar 2021

SARS-CoV-2 mutation T478K spreading at alarming speed in Mexico

Several SARS-CoV-2 variants have emerged, posing a renewed threat to COVID-19 containment and to vaccine and drug efficacy. In this study, we analyzed more than 820,000 SARS-CoV-2 genomic sequences deposited up to March 26, 2021 and identified a novel T478K mutation located on the SARS-CoV-2 Spike protein.

30 Mar 2021

Immune Response News and Research

New approach to CAR T gene therapy yields efficient and longer-lasting response against HIV

Combination of tumor cell vaccine and checkpoint therapy creates effective immune response

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

Muscle strength and mass may predict hospital stay duration in COVID-19 patients

Can asymptomatic COVID-19 confer long-term immunity?

Researchers develop a recombinant SARS-CoV-2 receptor-binding domain trimer vaccine candidate

Temperature difference in the upper and lower respiratory tract influences SARS-CoV-2 replication

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

Tamper-proof temperature indicator could help monitor ideal storage conditions of mRNA vaccines

New mRNA COVID-19 vaccine candidate shows promise in vivo

Are marine mammals are at risk of COVID-19?

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

Infliximab may hinder the effectiveness of some COVID-19 vaccines

SARS-CoV-2 inhibits the cellular response to interferon

NIAID researchers identify key player in the immune response to SARS-CoV-2

Study finds remarkable differences in the way individuals respond to malaria

Scientists receive NIH grant to monitor COVID-19 in wastewater

Study of twins reveals differences in adaptive immunity towards SARS-CoV-2

New coronavirus variant with E484K mutation detected in Arizona

SARS-CoV-2 mutation T478K spreading at alarming speed in Mexico

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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