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Simple blood test can detect a wide range of diseases

In diagnostic medicine, biopsies, where a sample of tissue is extracted for analysis, is a common tool for the detection of many conditions. But this approach has several drawbacks - it can be painful, doesn't always extract the diseased tissue, and can only be used in a sufficiently advanced disease stage, making it, in some cases, too late for intervention.

9 Feb 2021

Pancreatic β cells secrete miR-29 in response to high levels of free fatty acids

In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang's group and Antonio Vidal-Puig's group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output.

9 Feb 2021

New study describes the evolutionary tale of poisonous butterflies

The Atala butterfly (Eumaeus atala) and its five closest relatives in the genus Eumaeus like to display their toxicity.

8 Feb 2021

Study elucidates the mode of action of SGLT2 inhibitors in diabetes

Although SGLT-2 inhibitors are central to the treatment of diabetes, their exact mode of action was hitherto unknown.

8 Feb 2021

Experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients

A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized.

8 Feb 2021

How does SARS-CoV-2 infect the pancreas?

To understand how SARS-CoV-2 infects the pancreas and investigate its effects, a team of researchers used the human iPSC (induced pluripotent stem cells)-derived pancreatic cultures and analyzed the post-infection cellular and molecular changes.

5 Feb 2021

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called "cellular senescence," a permanent cell cycle arrest resulting from multiple stresses.

5 Feb 2021

New combination therapy proven to be highly effective in HBV infection model

Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer.

4 Feb 2021

Gut microbiome can modulate the immune response in liver cancer patients with NAFLD

The distinctive gut microbiome profile of a person with liver cancer linked to non-alcoholic fatty liver disease (NAFLD) could be the key to predicting someone's risk of developing the cancer, say researchers from the UNSW Microbiome Research Centre.

4 Feb 2021

Study finds cancer as the leading cause of death among patients with diabetes

Cancer is the leading cause of death among people with diabetes in England. This is the finding of an 18-year-study of over 300,000 people with diabetes in England, from scientists from Imperial College London and published in the journal The Lancet Diabetes & Endocrinology.

4 Feb 2021

Report estimates cancer incidence and mortality at the global level

Cancer ranks as a leading cause of death in every country in the world, and, for the first time, female breast cancer is the most commonly diagnosed cancer, overtaking lung cancer, according to a collaborative report, Global Cancer Statistics 2020, from the American Cancer Society and the International Agency for Research on Cancer.

4 Feb 2021

Study: Nalfurafine drug can help treat spinal morphine-induced itch in pregnant women

For years, many pregnant women and surgery patients have suffered from chronic itching when they get spinal or epidural morphine to reduce pain.

4 Feb 2021

Study shows that human hormones also follow a seasonal pattern

Our minds may be affected by winter's long nights or spring's flowers, but what about our bodies? A new study at the Weizmann Institute of Science reveals that our hormones also follow a seasonal pattern.

4 Feb 2021

Study: Remote supervision could expand access to neurointerventional technologies

Physicians training on novel technologies and surgical devices by other already experienced physicians, known as proctoring, is a fundamental aspect of medicine.

4 Feb 2021

Prevalence of underlying medical conditions related to severe COVID-19 is higher among cancer survivors

New study finds more than half (56.4%) of cancer survivors in the United States reported having additional underlying medical conditions associated with severe COVID-19 illness.

3 Feb 2021

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Pompe disease is a hereditary genetic disorder caused by a deficiency of acid alpha-glucosidase leading to build-up of glycogen in the lyosomes, which then causes cell damage in various tissues, in particular the heart, the muscles, the liver and the nervous system.

3 Feb 2021

Two studies describe processes that affect the generation of new fat cells

Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases.

3 Feb 2021

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

A new study by researchers at the University of Manchester, UK, reports on the compounds of interest that were identified as having potential for the treatment of COVID-19, from a library of almost 2,000 compounds from the APExBIO DiscoveryProbe library.

3 Feb 2021

Combining PD-1 and VEGF inhibitors with chemotherapy can help control cholangiocarcinoma

Cholangiocarcinoma (CCA) is considered as a diverse group of epithelial cancers characterized by poor outcomes. Cholangiocarcinoma can be divided into three types according to the original position: Intrahepatic Cholangiocarcinoma (ICC), Perihilar Cholangiocarcinoma (PCC), and Distal Extrahepatic Tumors (DET).

3 Feb 2021

Comprehensive study on prenatal causes of kidney disease in adults

A research group from Inselspital, Universitätsspital Bern and the University of Bern has published a comprehensive study on prenatal causes of kidney disease in adults in "Nature Communications".

3 Feb 2021

Liver News and Research

Simple blood test can detect a wide range of diseases

Pancreatic β cells secrete miR-29 in response to high levels of free fatty acids

New study describes the evolutionary tale of poisonous butterflies

Study elucidates the mode of action of SGLT2 inhibitors in diabetes

Experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients

How does SARS-CoV-2 infect the pancreas?

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

New combination therapy proven to be highly effective in HBV infection model

Gut microbiome can modulate the immune response in liver cancer patients with NAFLD

Study finds cancer as the leading cause of death among patients with diabetes

Report estimates cancer incidence and mortality at the global level

Study: Nalfurafine drug can help treat spinal morphine-induced itch in pregnant women

Study shows that human hormones also follow a seasonal pattern

Study: Remote supervision could expand access to neurointerventional technologies

Prevalence of underlying medical conditions related to severe COVID-19 is higher among cancer survivors

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Two studies describe processes that affect the generation of new fat cells

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

Combining PD-1 and VEGF inhibitors with chemotherapy can help control cholangiocarcinoma

Comprehensive study on prenatal causes of kidney disease in adults

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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