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Fluidigm announces universal sample prep workflow for single-cell DNA sequencing

Fluidigm Corporation today announced a universal sample prep workflow for single-cell DNA sequencing that runs on its C1TM Single-Cell Auto Prep System. This workflow streamlines targeted, whole exome and whole genome sequencing in heterogeneous cell populations and enables researchers to discover and screen somatic mutations, such as SNP, small indels, and translocations.

24 Dec 2013

Paired exchange and incompatible kidney transplant program launched by UAB

Ann Marie Reynolds, a 32-year-old who has been in and out of hospitals fighting chronic kidney disease since she was a teenager, had a less than 1 percent chance of receiving a kidney without the University of Alabama at Birmingham's groundbreaking organ donation system that helped her and two other hard-to-match patients get kidneys in a three-way, incompatible kidney exchange earlier this year.

24 Dec 2013

U.S. FDA grants Veloxis Orphan Drug status for Envarsus

Veloxis Pharmaceuticals A/S, today announced that Envarsus was granted Orphan Drug status by the U.S. Food and Drug Administration (FDA) for prophylaxis of organ rejection in patients receiving allogenic kidney transplants.

24 Dec 2013

Researchers report new gene delivery method that targets tumor blood vessels

Working in mice, researchers at Washington University School of Medicine in St. Louis report developing a gene delivery method long sought in the field of gene therapy: a deactivated virus carrying a gene of interest that can be injected into the bloodstream and make its way to the right cells.

24 Dec 2013

Epithelial-to-mesenchymal transition beneficial to cardiac regeneration

Cell-based therapies have been shown to enhance cardiac regeneration, but autologous (patient self-donated) cells have produced only "modest results." In an effort to improve myocardial regeneration through cell transplantation, a research team from Germany has taken epithelial cells from placenta (amniotic epithelial cells, or AECs) and converted them into mesenchymal cells. After transplanting the transitioned cells into mice modelling a myocardial infarction, the researchers found that the epithelial-to-mesenchymal transition was beneficial to cardiac regeneration by lowering infarct size.

24 Dec 2013

New CANHEART health index measures behaviours, health factors for optimal heart health

Fewer than 1 in 10 adult Canadians is in ideal cardiovascular health, according to the new CANHEART health index developed to measure heart health published in CMAJ (Canadian Medical Association Journal).

24 Dec 2013

Research review examines effectiveness of treatments for chronic skin wounds

A systematic review of 66 research papers focused on the treatment of skin ulcers suggests that most are so technically flawed that their results are unreliable. And even of those that pass muster, there is only weak evidence that some treatments work better than standard compression therapy or special stockings.

24 Dec 2013

Inosine drug raises blood and cerebrospinal fluid urate levels in Parkinson disease patients

The drug inosine appears to be a safe and effective way to raise blood and cerebrospinal fluid urate levels in patients with early Parkinson disease, suggesting it may be a potential strategy to slow the disability progression of the degenerative neurological disorder, according to a report published by JAMA Neurology, a JAMA Network publication.

23 Dec 2013

Hazards of dietary supplements, new birth control device explored

Dietary supplements account for nearly 20 percent of drug-related liver injuries reported by hospitals, according to The New York Times, while a surge in adverse event reports about Essure, a device hailed as next generation birth control, is explored by the Chicago Tribune. NPR looks at the increase in newborn screening tests.

23 Dec 2013

ANP reports positive interim results from ATL1103 Phase II clinical trial for acromegaly

Antisense Therapeutics Limited is pleased to advise that positive results have been achieved from the interim analysis of a subset of available data from its Phase II clinical trial of ATL1103 in patients with the growth disorder, acromegaly.

23 Dec 2013

First Edition: December 23, 2013

The early morning highlights from the major news organizations examine today's deadline for enrolling for health insurance that would begin Jan. 1, as well as a variety of other health law stories and several articles on mental health issues:

23 Dec 2013

European Commission approves update of Erbitux to treat patients with RAS wild-type mCRC

Merck Serono, the biopharmaceutical division of Merck, today announced that the European Commission has approved the Type II variation to amend the Erbitux(cetuximab) product information, updating the indication for Erbitux to the treatment of patients with RAS wild-type metastatic colorectal cancer (mCRC).

23 Dec 2013

Polymer Technology acquires A1CNow family of products from Bayer Diabetes Care

Polymer Technology Systems, Inc., the U.S.-based manufacturer of the CardioChek family of point-of-care diagnostic products, announced today that it has acquired the A1CNow® family of products from Bayer Diabetes Care.

23 Dec 2013

Study shows CAC screening plays prominent role in determining person's risk for heart attack and stoke

A new study shows that coronary artery calcium (CAC) screening, an assessment tool that is not currently recommended for people considered at low risk, should play a more prominent role in helping determine a person's risk for heart attack and heart disease-related death, as well as the need for angioplasty or bypass surgery.

23 Dec 2013

Icahn School of Medicine receives $1.3M grant to build collaborative research infrastructure for stroke center

The Icahn School of Medicine at Mount Sinai joins a top-flight network of 25 regional stroke centers announced by the National Institute of Health that will focus on prevention, treatment, and recovery from stroke.

23 Dec 2013

Researchers develop new vaccine that protects against lethal pneumonia caused by staph bacteria

University of Iowa researchers have developed a new vaccine that protects against lethal pneumonia caused by Staphylococcus aureus (staph) bacteria, including drug-resistant strains like MRSA.

23 Dec 2013

Death rates two times higher in postmenopausal women with anti-CCP and RA antibodies

New research shows mortality rates are two times higher in postmenopausal women with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (anti-CCP) antibodies. Findings published in the American College of Rheumatology (ACR) journal Arthritis & Rheumatism, soon to be called Arthritis & Rheumatology, indicate the higher mortality rates persisted after adjusting for age, positive rheumatoid factor, positive antinuclear antibodies (ANA) and disease modifying anti-rheumatic drug (DMARD) use.

23 Dec 2013

Report: Examine high-billing docs' Medicare billing to root out fraud

A report from the Department of Health and Human Services' inspector general to be released Friday will call for closer scrutiny of doctors' total billing. Elsewhere, ProPublica looks at how ineffective federal oversight is in looking for fraud in Medicare prescribing.

23 Dec 2013

Type 2 diabetes in women less than 45 triples risk of early menopause

Type 2 diabetes - the most common type of diabetes - triples the risk of an early menopause in women younger than 45 years of age, according to new research published in the peer-reviewed journal Climacteric.

23 Dec 2013

TSRI scientists identify compound that shows promise for treating obesity-linked diabetes

Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff-it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work.

23 Dec 2013

Blood News and Research

Fluidigm announces universal sample prep workflow for single-cell DNA sequencing

Paired exchange and incompatible kidney transplant program launched by UAB

U.S. FDA grants Veloxis Orphan Drug status for Envarsus

Researchers report new gene delivery method that targets tumor blood vessels

Epithelial-to-mesenchymal transition beneficial to cardiac regeneration

New CANHEART health index measures behaviours, health factors for optimal heart health

Research review examines effectiveness of treatments for chronic skin wounds

Inosine drug raises blood and cerebrospinal fluid urate levels in Parkinson disease patients

Hazards of dietary supplements, new birth control device explored

ANP reports positive interim results from ATL1103 Phase II clinical trial for acromegaly

First Edition: December 23, 2013

European Commission approves update of Erbitux to treat patients with RAS wild-type mCRC

Polymer Technology acquires A1CNow family of products from Bayer Diabetes Care

Study shows CAC screening plays prominent role in determining person's risk for heart attack and stoke

Icahn School of Medicine receives $1.3M grant to build collaborative research infrastructure for stroke center

Researchers develop new vaccine that protects against lethal pneumonia caused by staph bacteria

Death rates two times higher in postmenopausal women with anti-CCP and RA antibodies

Report: Examine high-billing docs' Medicare billing to root out fraud

Type 2 diabetes in women less than 45 triples risk of early menopause

TSRI scientists identify compound that shows promise for treating obesity-linked diabetes

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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