Protein C News and Research

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Genetics of bipolar disorder

The likelihood of developing bipolar disorder depends in part on the combined, small effects of variations in many different genes in the brain, none of which is powerful enough to cause the disease by itself, a new study shows.

9 May 2007

Gene mutation linked to cognition is found only in humans

The human and chimpanzee genomes vary by just 1.2 percent, yet there is a considerable difference in the mental and linguistic capabilities between the two species.

9 May 2007

Researchers create agent that protects cells from the lethal effects of radiation

No drugs exist to protect the public from the high levels of radiation that could be released by a "dirty" bomb or nuclear explosion.

9 May 2007

Abbott seeks U.S. and E.U. approvals for Humira as a treatment for juvenile rheumatoid arthritis

Abbott has announced it has simultaneously submitted a supplemental Biologics License Application (sBLA) with the U.S. Food and Drug Administration (FDA) and a Type II Variation to the European Medicines Agency (EMEA) seeking approval to market HUMIRA (adalimumab) as a treatment for juvenile rheumatoid arthritis (JRA) in the U.S. and juvenile idiopathic arthritis (JIA) in the European Union (EU).

9 May 2007

Alzheimer's disease, Parkinson's disease, type 2 diabetes similar at the molecular level

Alzheimer's disease, Parkinson's disease, type 2 diabetes, the human version of mad cow disease (Creutzfeldt-Jakob disease), and other degenerative diseases are more closely related at the molecular level than many scientists realized, an international team of researchers, including an ESRF researcher, report in the journal Nature.

8 May 2007

New compounds promising candidates for neurodegenerative disease drug development

Scientists have developed a novel strategy for tackling neurodegenerative diseases such as Huntington's disease: encouraging an individual's own cells to "eat" the malformed proteins that lead to the disease.

8 May 2007

Discovery may lead to new treatments for lung cancer and blood cancer

The research team uses a genetically modified mouse that produces a muted and constantly active CAAX protein. This is a new model for an extremely aggressive lung cancer and a mild form of blood cancer. In these mice, the production of an enzyme called GGTas1 can also be stopped.

8 May 2007

Heart-assist devices may help some end-stage heart failure patients avoid transplant

Implanted pumps improved heart function enough in a small percentage of patients awaiting a heart transplant that they were able to leave the hospital without a pump and without a new heart, according to a study in Circulation: Journal of the American Heart Association.

8 May 2007

First comprehensive profile of cell movement

Researchers at the University of California, San Diego (UCSD) School of Medicine have developed new technology which, combined with proteomics, the large-scale study of the structure and function of proteins and their functions, has allowed them to map an extensive network of the signaling proteins that control cell movement.

8 May 2007

Current approach to drug discovery for Lou Gehrig's disease be re-examined

Most research on Lou Gehrig's disease therapeutics has been based on the assumption that its two forms (sporadic and hereditary) are similar in their underlying cause.

8 May 2007

Loss of a single gene in kidney cancer cells causes them to stop making mitochondria

Studying a rare inherited syndrome, researchers at Johns Hopkins have found that cancer cells can reprogram themselves to turn down their own energy-making machinery and use less oxygen, and that these changes might help cancer cells survive and spread.

8 May 2007

Brain scans of people with mild cognitive impairment show signs of early Alzheimer's disease

For the study, PET scans were performed on the brains of 13 elderly men and women with mild cognitive impairment (MCI) and 14 elderly people without memory problems.

8 May 2007

Antidepressants induce new nerve cell growth in the hippocampus

The growth of new nerve cells in the hippocampus has been suggested as the way antidepressants work in rodents, says Eric Nestler, MD, PhD, of the University of Texas Southwestern Medical Center.

8 May 2007

How inhaled anthrax paralyzes the body's defenses

University of Florida researchers have revealed how the inhaled form of anthrax paralyzes the body's defenses and prevents immune cells from reaching the site of infection.

8 May 2007

Chickens which may have eaten contaminated feed go to market

The Agriculture Department in the United States (USDA) has given approval for 20 million chickens to be sold which may have been given feed contaminated with the chemical melamine.

8 May 2007

Health officials say low risk to humans from food containing melamine

There is very low risk to human health from consuming meat from hogs and chickens known to have been fed animal feed supplemented with pet food scraps that contained melamine and melamine-related compounds, according to an assessment conducted by scientists from five federal agencies.

7 May 2007

Health officials say low risk to humans from food containing melamine

7 May 2007

Molecule that destroys bone also protects it

An immune system component that is a primary cause of bone destruction and inflammation in autoimmune diseases such as rheumatoid arthritis actually protects bone in the oral cavity from infectious pathogens that play a major role in periodontal disease in humans, research at the University at Buffalo has shown.

7 May 2007

Increasing SUMO protein in brain could be a way of treating epilepsy and schizophrenia

The brain contains about 100 million nerve cells, each having 10,000 connections to other nerves cells. These connections, called synapses, chemically transmit the information that controls all brain function via proteins called receptors. These processes are believed to be the basis of learning and memory.

7 May 2007

Oral vaccine prevents prion disease in mice

An oral vaccine can prevent mice from developing a brain disease similar to mad cow disease, according to research presented at the American Academy of Neurology's 59th Annual Meeting in Boston.

4 May 2007

Protein C News and Research

Genetics of bipolar disorder

Gene mutation linked to cognition is found only in humans

Researchers create agent that protects cells from the lethal effects of radiation

Abbott seeks U.S. and E.U. approvals for Humira as a treatment for juvenile rheumatoid arthritis

Alzheimer's disease, Parkinson's disease, type 2 diabetes similar at the molecular level

New compounds promising candidates for neurodegenerative disease drug development

Discovery may lead to new treatments for lung cancer and blood cancer

Heart-assist devices may help some end-stage heart failure patients avoid transplant

First comprehensive profile of cell movement

Current approach to drug discovery for Lou Gehrig's disease be re-examined

Loss of a single gene in kidney cancer cells causes them to stop making mitochondria

Brain scans of people with mild cognitive impairment show signs of early Alzheimer's disease

Antidepressants induce new nerve cell growth in the hippocampus

How inhaled anthrax paralyzes the body's defenses

Chickens which may have eaten contaminated feed go to market

Health officials say low risk to humans from food containing melamine

Health officials say low risk to humans from food containing melamine

Molecule that destroys bone also protects it

Increasing SUMO protein in brain could be a way of treating epilepsy and schizophrenia

Oral vaccine prevents prion disease in mice

Industry Focus eBook - Cell biology (5th edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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