Protein C News and Research

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Variants of two genes involved in the inflammatory system linked to cognitive decline after heart surgery

Duke University Medical Center researchers believe their findings could help physicians identify patients at risk of suffering mental decline after heart surgery and raises the possibility that these patients could be treated with drugs that are known to dampen the inflammatory response.

2 May 2007

Biomarker discovery bodes well for better cancer diagnostics

While new findings from Ohio State University scientists suggest a genetic marker that could help distinguish between chronic pancreatitis and pancreatic cancer and gauge who will do well with cancer treatment, a pharmacologist at the Kimmel Cancer Center at Jefferson in Philadelphia sees the discovery as much more.

2 May 2007

Soy consumption and weight loss

Research shows that when soy consumption goes up, weight goes down.

2 May 2007

Evidence of very early onset defective bone mineralization in the lumbar spine revealed in children with cystic fibrosis

In a study of children with cystic fibrosis, French researchers found evidence of very early onset defective bone mineralization in the lumbar spine that was not caused by either nutritional status or lung disease.

2 May 2007

Rituximab reduces disease activity in multiple sclerosis

A new drug under investigation shows a reduction in disease activity in multiple sclerosis (MS), according to two studies that will be presented at the American Academy of Neurology's 59th Annual Meeting in Boston. The drug reduced disease activity as indicated by MRI scans.

2 May 2007

Wrapping version of Gleevec fights drug-resistant cancer

A new study highlighted on the cover of this week's issue of Cancer Research finds that the anti-cancer drug Gleevec? is far more effective against a drug-resistant strain of cancer when the drug wraps the target with a molecular bandage that seals out water from a critical area.

2 May 2007

Unstable leukemia stem cells may predispose patients to drug resistance

The BCR-ABL gene in chronic myeloid leukemia stem cells has a tendency to quickly mutate, and this may help explain why patients are predisposed to resistance to drugs like imatinib that target that gene, according to a study in the May 2 Journal of the National Cancer Institute.

2 May 2007

Combination treatment cures mice of a very aggressive human breast tumor

A combination of three different drugs that block the HER-2 receptor, a critical cellular growth signal for some breast cancers, eradicated aggressive breast tumors in mice and could point the way toward developing better treatments inpatients, said researchers from the Breast Center at Baylor College of Medicine in a report that appears today in the Journal of the National Cancer Institute.

2 May 2007

Methods for marking molecules to identify gene alterations and metabolic shifts

Physical alterations of DNA in chromosomes can cause serious diseases such as Down syndrome, Prader-Willi syndrome, or cancer.

2 May 2007

Mechanisms of glucose homeostasis and early diabetes

Glucose homeostasis, the appropriate balancing of blood sugar levels, is impaired early in patients who become diabetic, causing life-threatening complications such as kidney failure and heart attacks.

1 May 2007

New interactive map shows spread of avian flu virus

Scientists here have designed a new, interactive map of the spread of the avian flu virus (H5N1) that for the first time incorporates genetic, geographic and evolutionary information that may help predict where the next outbreak of the virus is likely to occur.

1 May 2007

Simvastatin may help sufferers with Alzheimer's

Treatment with Simvastatin, one of the statin drugs widely used for lowering cholesterol in humans, significantly improved spatial memory - how to navigate a water maze - in mice genetically bred to have an Alzheimer's like disease.

1 May 2007

Caution against over-aggressive use of erythropoiesis-stimulating agents for cancer-related anemia

Echoing recent FDA warnings, a research group from Northern Ireland cautions against over-aggressive use of a group of drugs called "erythropoiesis-stimulating agents" (ESAs) to treat anemia in some cancer patients, according to a commentary in the April issue of The Oncologist, published by AlphaMed Press.

1 May 2007

Google maps used to track avian flu spread

An interactive "supermap" that portrays the mutations and spread of the avian flu around the globe over time should help researchers and policy makers better understand the virus and anticipate further outbreaks, according to a new study involving University of Colorado at Boulder and Ohio State University researchers.

1 May 2007

Macadamia nuts can reduce cardiovascular disease risks

Incorporating macadamia nuts into a heart healthy diet can reduce cardiovascular disease risks according to Penn State researchers.

1 May 2007

Scientists find new way to analyze the moving parts of large proteins

Scientists from Baylor College of Medicine (BCM) and Rice University have discovered a new way to analyze the moving parts of large proteins , a breakthrough that will make it easier for structural biologists to classify and scrutinize the active sites of proteins implicated in cancer and other diseases.

1 May 2007

Alzheimer's, Parkinson's, type 2 diabetes are more closely related at the molecular level than scientists realized

Alzheimer's disease, Parkinson's disease, type 2 diabetes, the human version of mad cow disease, and other degenerative diseases are more closely related at the molecular level than scientists realized, a team reports this week in an advanced online publication of the journal Nature.

1 May 2007