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New gene associated with Lou Gehrig's disease

A collaborative research effort spanning nearly a decade between researchers at Massachusetts General Hospital (MGH) and King's College London (KCL) has identified a novel gene for inherited amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease).

26 Feb 2009

Amyloid plaques may increase the activity of astrocytes

The impact of the amyloid plaques that appear in the brains of patients with Alzheimer's disease may extend beyond the deposits' effects on neurons – the cells that transmit electrochemical signals throughout the nervous system.

26 Feb 2009

A second MND gene mutation in one year signifies rapid research progress

A collaborative research project involving Professor Christopher Shaw of the Institute of Psychiatry, King's College London (KCL), Dr Tom Kwiatkowski at Massachusetts General Hospital (MGH) and Professor Robert H Brown at University of Massachusetts, has revealed that mutations in a gene called FUS (fused in sarcoma) cause familial Motor Neuron Disease (also known as Amyotrophic Lateral Sclerosis).

26 Feb 2009

Scientists make electrically active motor neurons from iPS cells

Stem cells scientists at UCLA showed for the first time that human induced pluripotent stem (iPS) cells can be differentiated into electrically active motor neurons, a discovery that may aid in studying and treating neurological disorders.

25 Feb 2009

Stages of sleep have distinct influence on process of learning and memory

Research on the sleeping brain has revealed some fascinating stage-dependent interactions between areas involved in formation and storage of long term memories.

25 Feb 2009

Researchers find evidence for precise communication across brain areas during sleep

By listening in on the chatter between neurons in various parts of the brain, researchers from the California Institute of Technology (Caltech) have taken steps toward fully understanding just how memories are formed, transferred, and ultimately stored in the brain--and how that process varies throughout the various stages of sleep.

25 Feb 2009

Brain mechanism recruited to reduce noise during challenging tasks

New research reveals a sophisticated brain mechanism that is critical for filtering out irrelevant signals during demanding cognitive tasks.

25 Feb 2009

New insights into addiction

A new comprehensive review by researchers at the Montreal Neurological Institute (MNI), McGill University and the University of Cambridge, England provides vital insights into the neurological basis of addiction by investigating Parkinson's disease patients, who in some instances develop various addictions when undergoing medical treatment.

25 Feb 2009

Protein found linking stress and depression

Stress, the ever-present threat to health and happy living, is tough on the brain. If the strain goes on too long, it can lead to debilitating psychological problems.

25 Feb 2009

New theory of how animals smell

In the real world, odors don't happen one puff at a time. Animals move through, and subsequently distort, plumes of odor molecules that constantly drift, changing direction as the wind disperses them.

25 Feb 2009

Chili Peppers continue to help unravel mechanism of pain sensation

Capsaicin, the active ingredient in chili peppers, generally is viewed as an irritant that produces a burning sensation when applied to a sensitive area of the body, such as the cornea.

25 Feb 2009

Researchers generate functional neurons from induced pluripotent stem (iPS) cells

In a new study, researchers were able to generate functionally mature motor neurons from induced pluripotent stem (iPS) cells, which are engineered from adult somatic cells and can differentiate into most other cell types.

24 Feb 2009

Significant Rett syndrome discovery

A paper published online today in Nature Neuroscience reveals the presence of methyl CpG binding protein 2 (MeCP2) in glia. MeCP2 is a protein associated with a variety of neurological disorders, including Rett Syndrome, the most physically disabling of the autism spectrum disorders.

23 Feb 2009

Mechanisms that prevent Alzheimer's Disease: Enzymatic activity plays key role

In a project involving the collaboration of several institutes, research scientists of the Johannes Gutenberg University Mainz have succeeded in gaining further insight in the functioning of endogenous mechanisms that protect against the development of Alzheimer's disease.

23 Feb 2009

Human stem cells provide a new model for Lou Gehrig's disease

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a devastating condition in which motor neuron degeneration causes progressive loss of movement and muscle tone, leading to death.

23 Feb 2009

Researchers develop 'wireless' activation of brain circuits

Traditionally, stimulating nerves or brain tissue involves cumbersome wiring and a sharp metal electrode.

23 Feb 2009

Decoding short-term memory with functional magnetic resonance imaging

People voluntarily pick what information they store in short-term memory.

22 Feb 2009

Lynx2 gene linked to nervous behavior in mice

To measure anxiety in a mouse and suggest it's similar to anxiety in a person may seem like a stretch, but the metrics sound uncannily familiar.

20 Feb 2009

Drug sodium phenylbutyrate could improve the memory of those with Alzheimer's disease

The results of the project, developed by researchers of the Center for Applied Medical Research (CIMA) of the University of Navarra have been published in the journal Neuropsychopharmacology.

20 Feb 2009

Forgotten and lost -- when proteins 'shut down' our brain

Which modules of the tau protein, in neurons of Alzheimer disease patients, may act in a destructive manner were investigated by researchers from the Max Planck Institute for Biophysical Chemistry (Göttingen) and the Max Planck Unit for Structural Molecular Biology (Hamburg) with the help of Nuclear Magnetic Resonance Spectroscopy ( PLoS Biology , February 17, 2009).

18 Feb 2009