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Specific combinations of therapies kill cancer cells, reduce tumors

Controlling the time and sequence of cancer therapies may hold the key to unlocking better outcomes for patients with aggressive cancers, according to research published today.

12 Feb 2015

Understanding the pattern of cellular changes that lead to retinal ganglion cell death in glaucoma

Glaucoma, the second leading cause of blindness, usually stems from elevated eye pressure, which in turn damages and destroys specialized neurons in the eye known as retinal ganglion cells. To better understand these cellular changes and how they influence the progression and severity of glaucoma, researchers at University of California, San Diego School of Medicine and Shiley Eye Institute turned to a mouse model of the disease.

12 Feb 2015

USF researchers awarded grant to test new drug for age-related hearing loss

A successful treatment for age-related hearing loss (ARHL) is a step closer to reality, thanks to a group of researchers from the University of South Florida. The research team comprised of faculty and students has been awarded $400,000 by Autifony Therapeutics, Ltd, a company based in the United Kingdom, to test a new drug the company developed for ARHL.

12 Feb 2015

Oral pathogen protects different tumor cells from being killed by immune cells

Bacteria that are commonly found in the mouth are often abundant in patients with colon cancer, but the potential role these microbes play in tumor development has not been clear. A study published by Cell Press February 18th in the journal Immunity reveals that the oral pathogen Fusobacterium nucleatum protects a variety of tumor cells from being killed by immune cells.

12 Feb 2015

Diabetes medication can help white blood cells fight bacterial infections

Pioglitazone, a medication approved for treatment of type 2 diabetes, can help bypass genetic defects in chronic granulomatous disease to help white blood cells fight bacterial infections, according to researchers at National Jewish Health.

12 Feb 2015

Retigabine drug shows promise in protecting the brain against effects of ischemic stroke

Retigabine, a drug approved to treat epilepsy, protected the brain against the effects of ischemic stroke in a study conducted at The University of Texas Health Science Center at San Antonio.

12 Feb 2015

Study shows targeted therapeutic after chemotherapy kills transitional cancer cells

Timing may be decisive when it comes to overcoming cancer's ability to evade treatment. By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital (BWH) were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models.

12 Feb 2015

Common protein may play strategic role in tumor growth

A common, yet previously undistinguished protein, which is elevated in many late-stage cancers, may play a strategic role in tumor growth through a non-conventional pathway, researchers at the Indiana University School of Medicine report in the Feb. 10 issue of the Proceedings of the National Academy of Sciences.

12 Feb 2015

Expert panel makes new sleep-time recommendations

Loyola University Chicago Stritch School of Medicine researcher Lydia DonCarlos, PhD, is a member of an expert panel that's making new recommendations on how much sleep people need.

12 Feb 2015

Researchers develop novel approach to identify potential antimalarial drugs

Each year nearly 600,000 people--mostly children under age five and pregnant women in sub-Saharan Africa--die from malaria, caused by single-celled parasites that grow inside red blood cells. The most deadly malarial species--Plasmodium falciparum--has proven notoriously resistant to treatment efforts.

12 Feb 2015

SRI Biosciences awarded contract to develop novel polymers to neutralize chemical, biological threats

SRI Biosciences, a division of SRI International, has been awarded a $10 million contract under a DARPA program to reimagine how proteins are constructed and to develop novel medicines and diagnostics as countermeasures to chemical and biological threats.

12 Feb 2015

Franziska Michor named winner of Creative Promise Prize in Biomedical Science

Franziska Michor was picked as the winner of a Creative Promise Prize in Biomedical Science for her research that fuses evolutionary biology, mathematics, and clinical research toward a better understanding of cancer genesis and treatments.

12 Feb 2015

FDA advisory committees to review Amgen's talimogene laherparepvec for metastatic melanoma treatment

Amgen announced today that the Cellular, Tissue and Gene Therapies Advisory Committee and the Oncologic Drugs Advisory Committee of the U.S. Food and Drug Administration will jointly review the Company's Biologics License Application (BLA) for talimogene laherparepvec.

11 Feb 2015

Cumberland initiates clinical development of Boxaban (ifetroban) oral capsule for AERD treatment

Cumberland Pharmaceuticals Inc. today announced an expansion of its pipeline with a new Phase II development program. The Company has initiated the clinical development of Boxaban (ifetroban) oral capsule for the treatment of aspirin-exacerbated respiratory disease (AERD).

11 Feb 2015

Virginia Tech purchases two Bruker fluorescence microscope solutions

The Vutara 350 can break the optical diffraction limit by an order of magnitude, opening up a myriad of research opportunities in single-molecule cellular processes.

From Bruker 11 Feb 2015

Synthetic DNA gel could bring researchers closer to printing artificial organs

A two-part water-based gel made of synthetic DNA and peptide could bring the inventors of a 3D bio printer closer to being able to print organs for transplant, or to replace animal testing. The teams led by Dongsheng Liu (Tsinghua University) and Will Shu (Heriot-Watt University) faced two main challenges: finding a matrix or scaffold to support the live cells in 3D, and being able to produce a consistent product which would not be rejected by transplant recipients.

11 Feb 2015

First human clinical study of ChromaDex's NIAGEN nicotinamide riboside meets primary endpoint

ChromaDex Corp. announced today that the initial results of the first human clinical study for the company's NIAGEN nicotinamide riboside (NR) has met its primary endpoint.

11 Feb 2015

Research finds that mtDNA can move from healthy cell to dysfunctional tumour cell

Ground-breaking research from Griffith University on the Gold Coast has some scientists wondering if the entire study of cellular biology needs to be adjusted.

11 Feb 2015

OSU researchers discover impact of antibiotics on microorganisms that live in animal's gut

Researchers at Oregon State University have discovered that antibiotics have an impact on the microorganisms that live in an animal's gut that's more broad and complex than previously known.

11 Feb 2015

Single genomic change can make beneficial bacteria into pathogenic bacteria

We, as most animals, host many different beneficial bacteria. Being beneficial to the host often pays off for the bacteria, as success of the host determines the survival and spread of the microbe. But if bacteria grow too much they may become deadly.

11 Feb 2015

Cell News and Research

Specific combinations of therapies kill cancer cells, reduce tumors

Understanding the pattern of cellular changes that lead to retinal ganglion cell death in glaucoma

USF researchers awarded grant to test new drug for age-related hearing loss

Oral pathogen protects different tumor cells from being killed by immune cells

Diabetes medication can help white blood cells fight bacterial infections

Retigabine drug shows promise in protecting the brain against effects of ischemic stroke

Study shows targeted therapeutic after chemotherapy kills transitional cancer cells

Common protein may play strategic role in tumor growth

Expert panel makes new sleep-time recommendations

Researchers develop novel approach to identify potential antimalarial drugs

SRI Biosciences awarded contract to develop novel polymers to neutralize chemical, biological threats

Franziska Michor named winner of Creative Promise Prize in Biomedical Science

FDA advisory committees to review Amgen's talimogene laherparepvec for metastatic melanoma treatment

Cumberland initiates clinical development of Boxaban (ifetroban) oral capsule for AERD treatment

Virginia Tech purchases two Bruker fluorescence microscope solutions

Synthetic DNA gel could bring researchers closer to printing artificial organs

First human clinical study of ChromaDex's NIAGEN nicotinamide riboside meets primary endpoint

Research finds that mtDNA can move from healthy cell to dysfunctional tumour cell

OSU researchers discover impact of antibiotics on microorganisms that live in animal's gut

Single genomic change can make beneficial bacteria into pathogenic bacteria

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