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Inherited mutations in DNA repair genes may predispose to metastatic prostate cancer

Inherited mutations in genes that function to repair DNA may contribute to metastatic prostate cancer more than previously recognized, according to a study out today in the New England Journal of Medicine.

7 Jul 2016

World’s most intelligent prosthetic limb? An interview with Professor Saeed Zahedi

The main challenges for lower limb amputees are safety and pain. Lack of sensory feedback leading to an increased risk of falling, compensatory movements due to instability causing lower back pain and discomfort between the residual limb and prosthesis all contribute to a significant reduction in confidence and an inability to live a full life.

7 Jul 2016

New study estimates cost involved in training Teaching Health Center residents

A new study reveals that the average cost to train a Teaching Health Center resident is estimated to be $157,602 per year.

4 Jul 2016

Mitochondrial DNA levels may represent accurate, predictive measure of embryo viability in IVF

Despite the claims and counter-claims for new embryo assessment techniques introduced over the past two decades, the search for the holy grail of assisted reproduction - the key to the embryo destined to implant - continues.

4 Jul 2016

Researchers design E. coli-based transport capsule to help fight pneumococcal disease

Most people recoil at the thought of ingesting E. coli. But what if the headline-grabbing bacteria could be used to fight disease?

4 Jul 2016

Advances in inhaled drug delivery: an interview with Dr Robert Clarke

Delivering drugs to the lungs via inhalation has a number of potential advantages over traditional routes of administration like pills or injections. For treating pulmonary diseases, the obvious logic we are applying is topical delivery to the airways via inhalation.

1 Jul 2016

Resistant starch in diet improves balance of gut bacteria, decreases cholesterol

The secret ingredient is in the flour, but its impact lies within the gut. Adding resistant starch to the diets of people with metabolic syndrome can improve bacteria in the gut, according to research from South Dakota State University.

1 Jul 2016

New AAV 3.0 program to create next-generation viral vectors for better treatment of inherited diseases

The Perelman School of Medicine at the University of Pennsylvania has launched a new program, called AAV 3.0, to create new viral vectors to find quicker and better treatments for an array of diseases. James M. Wilson, MD, PhD, a professor of Medicine and director of the Orphan Disease Center, will lead an interdisciplinary team of over 30 scientists to create this new technology platform with support provided by the University of Pennsylvania Health System.

30 Jun 2016

Scientists use Sanger sequencing to conduct detailed genetic screening of PD patients

A team of scientists at the University of Granada has used a next-generation genetic sequencing method and a technique known as "Sanger sequencing" to conduct a detailed genetic screening of patients in Granada suffering from Parkinson's disease.

29 Jun 2016

Oncogene signatures could help design new drug treatments for breast cancer

Drug treatments for breast cancer patients might soon be designed based on the unique genetic autograph of their tumor.

25 Jun 2016

Cardiologist Emelia Benjamin receives AHA 2016 Gold Heart Award

Emelia J. Benjamin, MD, ScM, FACC, FAHA, professor of medicine in the section of cardiovascular medicine at Boston University School of Medicine, is the recipient of the American Heart Association's 2016 Gold Heart Award.

25 Jun 2016

Mice study shows influence of dad's obesity on daughter’s body weight and breast cancer risk

Obese male mice and normal weight female mice produce female pups that are overweight at birth through childhood, and have delayed development of their breast tissue as well as increased rates of breast cancer.

24 Jun 2016

Simple method may help predict type 2 diabetes risk in women with gestational diabetes

An international team of researchers has discovered a simple, accurate new way to predict which women with gestational diabetes will develop type 2 diabetes after delivery.

23 Jun 2016

New light-based technology facilitates deeper look into human body

New light-based technologies that facilitate a look inside the human body using light -- and without cutting into the tissue -- promise to enable both compact, wearable devices for point-of-care diagnostics as well as powerful new systems that provide even more information and from even deeper under the skin.

23 Jun 2016

Study shows many people may have potential to develop Huntington's disease

More people may have the potential to develop Huntington's disease than previously thought, according to a study published in the June 22, 2016, online issue of Neurology, the medical journal of the American Academy of Neurology.

23 Jun 2016

VUMC researchers aim to decode genetic underpinnings of human immune system

Researchers at Vanderbilt University Medical Center this month began recruiting volunteers to participate in a clinical trial aimed at decoding the human "immunome," the genetic underpinnings of the immune system.

22 Jun 2016

Experts use next-generation genetic sequencing to diagnose suspected brain infections

In a proof-of-principle study, a team of physicians and bioinformatics experts at Johns Hopkins reports they were able to diagnose or rule out suspected brain infections using so called next-generation genetic sequencing of brain tissue samples.

21 Jun 2016

Tumour protein TP53 can locate DNA targets autonomously to prevent cancer

Geneticists from KU Leuven, Belgium, have shown that tumour protein TP53 knows exactly where to bind to our DNA to prevent cancer. Once bound to this specific DNA sequence, the protein can activate the right genes to repair damaged cells.

17 Jun 2016

Adaptive Biotechnologies demonstrates use of high-throughput sequencing platform for MRD

Adaptive Biotechnologies, the leader in combining next-generation sequencing (NGS) and expert bioinformatics to profile T- and B-cell receptors of the adaptive immune system, and collaborators will be presenting five studies demonstrating how Adaptive’s high-throughput sequencing platform enables diagnosis, detection and assessment of prognosis in hematological malignances and has increased sensitivity over flow cytometry.

16 Jun 2016

NCMC develops national roadmap for large-scale manufacturing of cell-based therapeutics

An industry-driven consortium has developed a national roadmap designed to chart the path to large-scale manufacturing of cell-based therapeutics for use in a broad range of illnesses including cancer, neuro-degenerative diseases, blood and vision disorders and organ regeneration and repair.

15 Jun 2016

Next Generation News and Research

Inherited mutations in DNA repair genes may predispose to metastatic prostate cancer

World’s most intelligent prosthetic limb? An interview with Professor Saeed Zahedi

New study estimates cost involved in training Teaching Health Center residents

Mitochondrial DNA levels may represent accurate, predictive measure of embryo viability in IVF

Researchers design E. coli-based transport capsule to help fight pneumococcal disease

Advances in inhaled drug delivery: an interview with Dr Robert Clarke

Resistant starch in diet improves balance of gut bacteria, decreases cholesterol

New AAV 3.0 program to create next-generation viral vectors for better treatment of inherited diseases

Scientists use Sanger sequencing to conduct detailed genetic screening of PD patients

Oncogene signatures could help design new drug treatments for breast cancer

Cardiologist Emelia Benjamin receives AHA 2016 Gold Heart Award

Mice study shows influence of dad's obesity on daughter’s body weight and breast cancer risk

Simple method may help predict type 2 diabetes risk in women with gestational diabetes

New light-based technology facilitates deeper look into human body

Study shows many people may have potential to develop Huntington's disease

VUMC researchers aim to decode genetic underpinnings of human immune system

Experts use next-generation genetic sequencing to diagnose suspected brain infections

Tumour protein TP53 can locate DNA targets autonomously to prevent cancer

Adaptive Biotechnologies demonstrates use of high-throughput sequencing platform for MRD

NCMC develops national roadmap for large-scale manufacturing of cell-based therapeutics

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