Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Researchers identify molecular processes crucial for the maturation of Group 2 innate lymphoid cells

Scientists have discovered a novel mechanism of ILC2 immune cell development which may be involved in exacerbating allergic diseases.

11 Jul 2024

GLP-1 drugs found to lower cancer risk in diabetes patients

Research finds that GLP-1 receptor agonists significantly reduce the risk of 10 out of 13 obesity-associated cancers in type 2 diabetes patients compared to insulins, but show varied results against metformin.

8 Jul 2024

New hope for solid tumors with enhanced CAR-T cells

A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more efficiently. Thanks to a recent study published in Molecular Therapy – Methods & Clinical Development from Dan Cappabianca and Krishanu Saha at the Wisconsin Institute for Discovery, Chimeric Antigen Receptor (CAR) T-cell therapy can be improved by altering the conditions the T cells are grown in. And it was all discovered by chance.

3 Jul 2024

High-impact exercise boosts bone density without harming knee health in postmenopausal women

Study demonstrates that six months of high-impact unilateral exercise significantly improves femoral neck bone density in postmenopausal women without negatively affecting knee osteoarthritis progression.

2 Jul 2024

Early detection of aggressive multiple myeloma through molecular analysis

Multiple myeloma is one of the most common forms of cancer of the immune cells in the bone marrow. It is considered incurable.

1 Jul 2024

Targeted gene therapy may reduce AML burden and protect the heart from cardiotoxicity

Researchers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia (AML) more sensitive to chemotherapy, while also protecting the heart against toxicity often caused by cancer treatments.

27 Jun 2024

Early diagnosis key in combating the deadly effects of AL amyloidosis

AL (immunoglobulin light chain) amyloidosis is a rare disease that often results in progressive organ dysfunction, organ failure and eventual death.

27 Jun 2024

New curative treatment for sickle cell disease shows promising results in international trial

Vanderbilt University Medical Center (VUMC) researchers are touting data from a multicenter, international phase 2 clinical trial showing a new, curative treatment for sickle cell disease (SCD).

25 Jun 2024

Hematopoietic stem cells in the bone marrow age differently in genetically identical mice

Our bone marrow - the fatty, jelly-like substance inside our bones - is an unseen powerhouse quietly producing 500 billion new blood cells every day.

21 Jun 2024

Ohio State study unveils white blood cells' role in nerve fiber regeneration

In a new study, neuroscience researchers at The Ohio State University have discovered a special type of human white blood cell that has the potential to regrow nerve fibers.

20 Jun 2024

JAK inhibitor ruxolitinib enhances immunotherapy in Hodgkin lymphoma patients

Checkpoint inhibitor therapies can be thought of as the molecular "brake release" for the immune system.

20 Jun 2024

New bone marrow atlas offers detailed view of cell function and organization

While research has uncovered many details about how blood cells function within bone marrow, the work of other cells existing in that space remained a relative mystery.

18 Jun 2024

Promising gene editing therapy shows hope in sickle cell disease cure

Researchers have presented the latest findings from a clinical trial aimed at discovering a cure for sickle cell disease, a painful genetic blood disorder with limited treatment options.

14 Jun 2024

MEK inhibitor trametinib shows potential in pediatric JMML treatment

The MEK inhibitor trametinib (Mekinist) was an effective treatment for pediatric patients with relapsed or refractory juvenile myelomonocytic leukemia (JMML) enrolled in a phase II clinical trial, with seven of 10 patients alive after a median of two years.

13 Jun 2024

Stanford study finds low risk of secondary blood cancers after CAR-T cell therapy

A large study by researchers at Stanford Medicine has found that the risk of secondary blood cancers after CAR-T cell therapy - a cell-based cancer treatment that exploded on the scene in 2017 as a treatment for intractable blood cancers - is low, despite a Food and Drug Administration warning.

12 Jun 2024

Precision medicine revolutionizes outcomes for high-risk pediatric cancer patients

In a world-first, Australian researchers and clinicians have shown that precision medicine – where treatment is tailored to an individual child's cancer – leads to significantly improved outcomes in children with high risk cancer.

6 Jun 2024

Unveiling the heterogeneity of skeletal stem cells across skeletal regions and developmental stages

SSCs are essential for bone development, homeostasis, and repair. Recent studies have identified distinct SSC populations in long bones, craniofacial bones, and spine.

5 Jun 2024

Applied Cells releases game-changing reagent kits to empower cell therapy development

Applied Cells is excited to announce the launch of its MARS® Ingenuity™ Reagent kits for fast and easy cell isolation. This innovative product line features both RUO and GMP-grade reagents, and has been specifically optimized for use on Applied Cells’ proprietary MARS® Bar platform.

From Applied Cells 4 Jun 2024

Young bone marrow transplants show promise in reversing Alzheimer's symptoms in mice

Researchers found that young bone marrow transplants rejuvenate aging immune cells, reducing Alzheimer's symptoms in mice models, suggesting a potential therapeutic approach for the disease.

4 Jun 2024

Type 2 diabetes linked to higher cancer risk, especially with diabetic retinopathy, study finds

A recent study in BMC Medicine found that type 2 diabetes significantly increases the risk of various cancers, with the risk being even higher in patients with diabetic retinopathy (DR).

2 Jun 2024