Glioblastoma News and Research

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Glioblastoma is the most aggressive and malignant form of glioma, a type of primary brain cancer. Surgery is often used to treat gliomas, along with radiation. However, since surgery and radiation fail to cure the disease, doctors may turn to additional radiation or chemotherapy. In early stages glioblastoma tumors often grow without symptoms and therefore can become quite large before symptoms arise. When the tumor becomes symptomatic, tumor growth is usually very rapid and is accompanied by altered brain function, and if left untreated the disease becomes lethal. Although primary treatment is often successful in temporarily stopping the progression of the tumor, glioblastomas almost always recur and become lethal.

Barrow Institute initiates $50 million effort to seek cure for glioblastoma

Barrow Neurological Institute has initiated a $50 million effort, supported by the single largest research grant in the history of brain tumor research, to seek a cure for the deadliest form of brain cancer.

11 Sep 2018

Researchers uncover secret of immortality mechanism in aggressive glioblastoma

UC San Francisco researchers have discovered how a mutation in a gene regulator called the TERT promoter -- the third most common mutation among all human cancers and the most common mutation in the deadly brain cancer glioblastoma -- confers "immortality" on tumor cells, enabling the unchecked cell division that powers their aggressive growth.

10 Sep 2018

Novel approach reveals metabolic vulnerabilities in kidney cancer

In order to halt the growth of cancer cells, you have to know what feeds them. Researchers at the nationally recognized Kidney Cancer Program at UT Southwestern's Harold C. Simmons Comprehensive Cancer Center have developed a novel approach using glucose that may open up new opportunities for therapeutic intervention.

30 Aug 2018

Cancer-hunting stem cells may be potential drug delivery tool for medulloblastoma

The latest in a series of laboratory breakthroughs could lead to a more effective way to treat the most common brain cancer in children.

30 Aug 2018

Additional inhibitor could be key to helping anti-VEGF therapies overcome resistance in glioblastoma

Adding another inhibitor to therapies that cut off a tumor's access to blood vessels could be the key to helping those therapies overcome resistance in glioblastoma, a deadly form of brain cancer.

27 Aug 2018

Death of Sen. John McCain sheds new light on aggressive brain tumor

The death today of Sen. John McCain (R-Ariz.) sheds a new light on glioblastoma, a form of brain cancer that the American Brain Tumor Association estimated would be diagnosed in nearly 13,000 people this year.

27 Aug 2018

Mccain’s complicated health care legacy: He hated the ACA. He also saved it.

There are many lawmakers who made their names in health care, seeking to usher through historic changes to a broken system.

27 Aug 2018

Brain tumors trap immune cells needed to fight cancer in the bone marrow, finds research

Certain brain cancers are associated with low numbers of immune system T-cells circulating in the peripheral blood. Low T-cell numbers can be a side-effect of cancer treatment. But it now appears that there is more to the story of these missing T-cells.

20 Aug 2018

Scientists explore ways for drug therapies to reach deadly brain tumors

The blood-brain barrier is a specialized network of vascular and brain cells that acts as the brain's security system, helping to safeguard the brain and regulate the flow of substances into and out of it.

15 Aug 2018

Duke researchers track missing T-cells in glioblastoma patients

Glioblastoma brain tumors can have an unusual effect on the body's immune system, often causing a dramatic drop in the number of circulating T-cells that help drive the body's defenses.

13 Aug 2018

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

In the first such clinical trial in the United States, physician-scientists with the University of Maryland School of Medicine are investigating the use of MRI-guided focused ultrasound to open the blood-brain barrier.

10 Aug 2018

Scientists deliver nano-size packets of genetic code to treat brain tumors in mice

In a "proof of concept" study, scientists at Johns Hopkins Medicine say they have successfully delivered nano-size packets of genetic code called microRNAs to treat human brain tumors implanted in mice.

12 Jul 2018

Researchers elucidate role of mutations in deadly brain cancer

Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have discovered how different mutations in a specific gene help drive glioblastoma, the most lethal form of brain cancer.

11 Jul 2018

Altitude sickness drug may offer significant gains for patients with glioblastoma

A drug used to treat altitude sickness -- as well as glaucoma, epilepsy, heart failure and seizures -- may also offer significant gains for patients with a fast-growing brain tumor known as glioblastoma, according to a study published July 4, 2018, in the journal Science Translational Medicine.

10 Jul 2018

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

A Ludwig Cancer Research study explains why a particular mutation in the epidermal growth factor receptor, a cell surface protein, results in more aggressive tumors and poorer overall survival of patients diagnosed with the brain cancer glioblastoma multiforme.

10 Jul 2018

Engineers develop new method to measure and reconstruct interstitial fluid flow in the brain

Interstitial fluid transports nutrients and removes waste between the organs and tissues in our body. In the brain, interstitial fluid is thought to be composed of circulating cerebrospinal fluid, cellular waste and blood plasma, and past research has shown a link between interstitial fluid flow and an increased invasion rate of glioblastoma, or brain tumor, cells.

4 Jul 2018

Viral immunotherapy shows promise to treat pediatric brain tumors

A viral immunotherapy using a herpes virus to treat brain tumors has been shown to be safe and well-tolerated in a pediatric study from the University of Alabama at Birmingham and Children's of Alabama.

4 Jul 2018

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

The California Institute for Regenerative Medicine board has awarded City of Hope $3.7 million to develop a phase 1 clinical trial for glioblastoma patients that will genetically engineer their stem cells to better tolerate chemotherapy's side effects, allowing them to receive higher doses of the therapy.

30 Jun 2018

Study finds sex-based differences in genetic risk factors for developing gliomas

Glioma is the most common type of primary malignant brain tumor in the United States; glioblastoma being the most common type of glioma in adults.

29 Jun 2018

Genetic biomarker can help predict survival outcomes in patients with certain gliomas

A DNA-level biomarker (MGMT promoter methylation) can be used to help predict survival outcomes in patients with high-risk, low-grade gliomas, according to a new study conducted through the NRG Oncology/RTOG collaborative clinical trials group and led by scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

28 Jun 2018

Glioblastoma News and Research

Further Reading

Barrow Institute initiates $50 million effort to seek cure for glioblastoma

Researchers uncover secret of immortality mechanism in aggressive glioblastoma

Novel approach reveals metabolic vulnerabilities in kidney cancer

Cancer-hunting stem cells may be potential drug delivery tool for medulloblastoma

Additional inhibitor could be key to helping anti-VEGF therapies overcome resistance in glioblastoma

Death of Sen. John McCain sheds new light on aggressive brain tumor

Mccain’s complicated health care legacy: He hated the ACA. He also saved it.

Brain tumors trap immune cells needed to fight cancer in the bone marrow, finds research

Scientists explore ways for drug therapies to reach deadly brain tumors

Duke researchers track missing T-cells in glioblastoma patients

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

Scientists deliver nano-size packets of genetic code to treat brain tumors in mice

Researchers elucidate role of mutations in deadly brain cancer

Altitude sickness drug may offer significant gains for patients with glioblastoma

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

Engineers develop new method to measure and reconstruct interstitial fluid flow in the brain

Viral immunotherapy shows promise to treat pediatric brain tumors

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

Study finds sex-based differences in genetic risk factors for developing gliomas

Genetic biomarker can help predict survival outcomes in patients with certain gliomas

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