Glioma News and Research

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Glioma is a cancer of the brain that begins in glial cells (cells that surround and support nerve cells).

Nanodiamonds deliver chemotherapy directly into brain tumors

Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed an innovative drug-delivery system in which tiny particles called nanodiamonds are used to carry chemotherapy drugs directly into brain tumors.

13 Sep 2013

Umbilical cord mesenchymal stem cells may have targeting capacity for glioma

Glioblastoma is the most common ma-lignant primary brain tumor in adults. The aggressive growth manner, characterized by marked angiogenesis and extensive tumor cell invasion into normal brain parenchyma with frequent formation of tumor microsatellites at distal sites, makes eradication impossible even after extensive microsurgical resection combined with current standard chemoradiation and adjuvant temozolomide.

11 Sep 2013

New drug delivery system using NDs allows for direct application of chemotherapy to brain tumors

Researchers at UCLA's Jonsson Comprehensive Cancer Center have developed a new drug delivery system using nanodiamonds (NDs) that allows for direct application of chemotherapy to brain tumors with fewer harmful side effects and better cancer-killing efficiency than existing treatments.

10 Sep 2013

BMP linked to increased risk of benign tumors, not cancers

Patients undergoing spinal fusion surgery with bone morphogenetic protein (BMP) appear to be at increased risk of benign tumors—but not cancers, reports a study in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

7 Sep 2013

Scientists develop robotic systems for image-guided removal of hard-to-reach brain tumors

NIBIB-funded scientists and engineers are teaming up with neurosurgeons to develop technologies that enable less invasive, image-guided removal of hard-to-reach brain tumors.

6 Sep 2013

Protein activated by inflammation converts glioblastoma multiforme cells to most aggressive form

A prominent protein activated by inflammation is the key instigator that converts glioblastoma multiforme cells to their most aggressive, untreatable form and promotes resistance to radiation therapy, an international team lead by researchers at The University of Texas MD Anderson Cancer Center reported online today in the journal Cancer Cell.

30 Aug 2013

Virttu Biologics treats first cohort of patients in SEPREHVIR Phase I/IIa study

Virttu Biologics Limited, a UK biotechnology company with expertise in the field of oncolytic viruses, has announced that it has treated the first cohort of patients in its Phase I/IIa clinical study of its oncolytic virus, SEPREHVIR (HSV1716) for the treatment of malignant pleural mesothelioma.

27 Aug 2013

Bioactive compounds in coffee may prevent prostate cancer recurrence, delay progression

Coffee consumption is associated with a lower risk of prostate cancer recurrence and progression, according to a new study by Fred Hutchinson Cancer Research Center scientists that is online ahead of print in Cancer Causes & Control.

27 Aug 2013

Neural stem cells transplantation in tumor-bearing rats can hinder tumor cell growth

Neural stem cells transplanted into tumor-bearing rats can hinder tumor cell growth and prolife-ration; however, the mechanism remains unclear.

14 Aug 2013

Brain tumor cells in arrested development contribute to cell variety that protects cancer

A program that pushes immature cells to grow up and fulfill their destiny as useful, dedicated cells is short-circuited in the most common and deadly form of brain tumor, scientists at The University of Texas MD Anderson Cancer Center report this week in the Early Edition of the Proceedings of the National Academy of Sciences.

8 Aug 2013

Affymetrix introduces new OncoScan FFPE Assay Kit

Affymetrix, Inc. announced the launch of the new OncoScan™ FFPE Assay Kit, a whole-genome copy number assay for highly degraded FFPE solid tumor samples, at the Cancer Cytogenomics Microarray Consortium conference being held in Chicago this week.

5 Aug 2013

Nektar completes enrollment in NKTR-102 BEACON trial in patients with metastatic breast cancer

Nektar Therapeutics (NASDAQ: NKTR) today announced that enrollment is complete in the pivotal clinical study of etirinotecan pegol (NKTR-102) in patients with metastatic breast cancer.

31 Jul 2013

Diffusion tensor imaging fiber tracking can show fiber bundles in human brain

Diffusion tensor imaging fiber tracking with reliable tracking orientation and flexible step size can show white matter fiber bundles in the healthy corpus callosum.

24 Jul 2013

3-D hydrogel approach to study aggressive and deadly forms of brain cancer

Human glioblastoma multiforme, one of the most common, aggressive and deadly forms of brain cancer, is notoriously difficult to study. Scientists have traditionally studied cancer cells in petri dishes, which have none of the properties of the brain tissues in which these cancers grow, or in expensive animal models.

24 Jul 2013

TAp73 protein frequently overexpressed in wide range of human tumors

They say you can pick your friends, but not your family. The same may hold true for related proteins. The protein TAp73 is a relative of the well-known, tumor-suppressor protein p53. It shares extensive common gene sequences with p53 and, as suggested by some previous studies, it may function similar to p53 to prevent tumor formation.

17 Jul 2013

GAPVAC aims to develop personalized therapeutic vaccines for cancer

A highly innovative project supported by a €6 million European Union Framework 7 (EU FP7) program grant to develop a novel class of therapeutic cancer vaccines is now under way.

4 Jul 2013

Abnormal metabolic pathway drives cancer-cell growth in glioblastoma subtype

A study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has identified an abnormal metabolic pathway that drives cancer-cell growth in a particular glioblastoma subtype. The finding might lead to new therapies for a subset of patients with glioblastoma, the most common and lethal form of brain cancer.

14 Jun 2013

New weapon in the fight against childhood brain cancer emerges

A relatively new weapon in the fight against childhood brain cancer has emerged that improves upon standard magnetic resonance imaging by providing information about tumor metabolism and extent of cancer in children diagnosed with glioma, a growth caused by the abnormal division of glial cells in the brain, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting.

11 Jun 2013

Scientists pinpoint genetic traits of cells that give rise to gliomas

A multi-institutional team of researchers have pinpointed the genetic traits of the cells that give rise to gliomas - the most common form of malignant brain cancer. The findings, which appear in the journal Cell Reports, provide scientists with rich new potential set of targets to treat the disease.

4 Jun 2013

Radiotherapy: First choice treatment for low-grade glioma

In a large, international, randomized trial, initial radiotherapy was compared to temozolomide chemotherapy. A statistically significant difference between the two treatment strategies was not observed for progression-free survival, although radiotherapy was numerically favored. However, molecular tumor characterization may allow the treatment approach to be personalized and one or the other treatment modality to be selected.

30 May 2013