Induced Pluripotent Stem Cells News and Research

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Researchers develop first blood-brain barrier chip using stem cells

Researchers at Ben-Gurion University of the Negev and Cedars-Sinai Medical Center in Los Angeles have, for the first time, duplicated a patient's blood-brain barrier, creating a human BBB chip with stem cells, which can be used to develop personalized medicine and new techniques to research brain disorders.

13 Jun 2019

URMC biotech start-up receives funding to develop cell-based therapies for neurological disorders

Oscine Therapeutics, a new biotechnology company based on discoveries made and developed at the University of Rochester Medical Center has received a significant multi-year investment to support both research and development of cell-based therapies for neurological disorders.

11 Jun 2019

'Eye-in-a-dish' model helps scientists to uncover 'surprising' AMD gene variant

Researchers have discovered a new genetic variant responsible for blood vessel dysregulation in the development of age-related macular degeneration (AMD).

29 May 2019

Study reveals how genetic message to produce healthy heart tissue is altered during stress, aging

Researchers at the Fralin Biomedical Research Institute at Virginia Tech Carilion have revealed how a genetic message to produce healthy heart tissue is altered in the body during stress and aging to contribute to sudden cardiac death.

29 May 2019

Stem cell study reveals the harmful effects of flavored e-cigarette liquids

Your favorite vape flavor may be more harmful than the nicotine itself. Using stem cells to investigate the impact of e-liquids on cardiovascular disease, a new study has revealed the harmful effects of flavored e-cigarette liquids and e-cigarette use.

28 May 2019

Acute exposure to flavored e-liquids exacerbates endothelial cell dysfunction, study finds

There has been a rapid rise in e-cigarette use, but its health effects have not been well-studied and their effect on vascular health remains unknown.

28 May 2019

Rutgers-led study pinpoints key gene linked to impaired memory in Down syndrome

Targeting a key gene before birth could someday help lead to a treatment for Down syndrome by reversing abnormal embryonic brain development and improving cognitive function after birth, according to a Rutgers-led study.

24 May 2019

'Eye-in-a-dish' model reveals genetic variants that may contribute to AMD

Age-related macular degeneration is one of the most common causes of vision loss in people over age 65.

10 May 2019

Scientists successfully create melanocyte precursor cells using stem cell technology

Our hair, skin and eyes are colored by a pigment called melanin, which is produced by pigment cells called melanocytes. Scientists have used stem cell technology to successfully create melanocyte precursor cells.

10 May 2019

Human iPSCs make more tiny 'cargo packets' to deliver cellular aging therapies

Johns Hopkins scientists report that adult cells reprogrammed to become primitive stem cells, called induced pluripotent stem cells, make tiny "cargo packets" able to deliver potentially restorative or repairing proteins, antibodies or other therapies to aged cells.

From Johns Hopkins Medicine 8 May 2019

Scientists describe how cells 'decide' between pluripotency and differentiation

Induced pluripotent stem cells can turn into any type of cell in the body or remain in their original form. In the current edition of Molecular Cell, scientists from the Helmholtz Zentrum München describe how cells “decide” which of these two directions to take.

3 May 2019

Genetic mutations in brain development lead to discovery of rare genetic diseases

Mutations in a gene involved in brain development have led to the discovery of two new neurodevelopmental diseases by an international team led by researchers at McGill University and CHU Sainte-Justine Research Center.

26 Apr 2019

Combining biomaterial scaffolds with stem cells for tissue engineering applications

StemJournal, a new open access, peer-reviewed journal published by IOS Press, announces publication of its inaugural article, "Combining Stem Cells and Biomaterial Scaffolds for Constructing Tissues and Cell Delivery," by Stephanie M. Willerth, PhD, and Shelly E. Sakiyama-Elbert, PhD.

25 Apr 2019

Researchers create a working model of cerebral tract to study brain function

It takes a lot of connections to create human intelligence. Brain function depends on contacts between multiple regions within the brain.

19 Apr 2019

Two new epigenetic regulators maintain self-renewal of embryonic stem cells

Embryonic stem cells have the ability to self-renew, and, being pluripotent have the potential to create almost any cell type in the body.

19 Apr 2019

New catalog of DNA mutation 'fingerprints' could help doctors pinpoint cancer culprits

Scientists in Cambridge and London have developed a catalog of DNA mutation 'fingerprints' that could help doctors pinpoint the environmental culprit responsible for a patient's tumor - including showing some of the fingerprints left in lung tumors by specific chemicals found in tobacco smoke.

16 Apr 2019

Scientists investigate processes that lead to neuronal death in ALS patients

Amyotrophic lateral sclerosis is an incurable disease of the central nervous system. In most cases, ALS is fatal within a short period following diagnosis.

15 Apr 2019

Human iPSCs-derived mesenchymal stem cells could avoid ageing-related shortfalls

The use of primary mesenchymal stem cells is fraught with ageing-related shortfalls such as limited expansion and early senescence.

11 Apr 2019

UC San Diego Health treats first cancer patient with iPSC-derived cell therapy

After 10 years in remission, Derek Ruff's cancer returned, this time as stage IV colon cancer. Despite aggressive rounds of chemotherapy, palliative radiotherapy and immunotherapy, his disease progressed.

2 Apr 2019

Researchers develop new technology to mass produce cerebral cortex neurons

Korea Brain Research Institute (KBRI, President Pann Ghill Suh) announced on Mar. 4 that its research team led by principal researcher Yoichi Kosodo developed a technology to mass produce cerebral cortex neurons utilizing Induced pluripotent Stem Cells.

28 Mar 2019