Ritonavir News and Research

RSS

Ritonavir, also known as Norvir, is a type of medicine called a protease inhibitor (PI). PIs act by blocking protease, a protein that HIV needs to make more copies of itself. Ritonavir was approved by the FDA on March 1, 1996, for use with other antiretroviral agents in the treatment of HIV infection in adults and children 2 years of age or older. Ritonavir is now approved with other anti-HIV drugs in the treatment of HIV-1 infection in children in individuals over 1 month in age. Studies have shown that ritonavir works as a booster for some other PIs. Taking ritonavir makes it possible to take a lower dose of the other PIs. This medicine does not cure or prevent HIV infection or AIDS and does not reduce the risk of passing the virus to other people.

Abbott Labs agrees to settle lawsuit over antiretroviral Norvir pricing

Abbott Laboratories on Wednesday agreed to pay between $10 million and $27.5 million to settle an antitrust lawsuit filed by HIV/AIDS advocates and other drug companies over an increase in the price of the company's antiretroviral drug Norvir, the AP/International Herald Tribune reports (AP/International Herald Tribune, 7/31).

3 Aug 2008

Gilead initiates phase III trial of Elvitegravir

Gilead Sciences, Inc. has announced that it has begun enrolling patients in a Phase III clinical trial of its investigational antiretroviral agent elvitegravir (GS 9137), a novel oral integrase inhibitor that is being evaluated for the treatment of HIV-1 infection.

22 Jul 2008

Clinton Foundation, UNITAID announce new antiretroviral discounts

The Clinton Foundation HIV/AIDS Initiative and UNITAID on Monday announced that they have negotiated agreements with generic drug companies that will reduce the cost of some antiretroviral drugs and provide new pediatric formulations, the Wall Street Journal reports.

29 Apr 2008

Pharmacies, drug wholesaler file lawsuit against Abbott over price of antiretroviral Norvir

Four pharmacy chains and one pharmaceutical wholesaler on Monday filed a lawsuit against Abbott Laboratories over the price of its antiretroviral drug Norvir, the Wall Street Journal reports.

30 Oct 2007

Etravirine reduces HIV viral loads when taken with Prezista

The experimental antiretroviral drug etravirine, made by Johnson & Johnson subsidiary Tibotec Pharmaceuticals, greatly reduces HIV viral loads in people with a history of drug resistance when taken in combination with Tibotec's antiretroviral Prezista, according to two studies published Saturday in the journal The Lancet.

10 Jul 2007

Darunavir-ritonavir shows benefits for patients with HIV

Darunavir-ritonavir should be considered as a treatment option across the range of treatment-experienced patients with HIV infection, conclude Jose Madruga (Centro de Referencia e Treinamento DST/AIDS, Sao Paulao, Brazil) and colleagues in an Article in this week's issue of The Lancet.

8 Jul 2007

WHO welcomes decision by Abbott Labs to reduce price of lopinavir/ritonavir

The World Health Organization (WHO) is committed to work towards universal access, by 2010, to HIV prevention services and to treatment and care for people living with HIV/AIDS.

11 Apr 2007

Abbott agrees with WHO to expand access to lopinavir / ritonavir

Abbott and World Health Organization (WHO) Director-General, Margaret Chan, have agreed on a balanced approach to provide Kaletra/Aluvia (lopinavir/ritonavir) capsules and tablets to more patients in the developing world, while supporting continued long-term biopharmaceutical research and development.

10 Apr 2007

Bristol-Myers Squibb receives FDA approval for new formulation of antiretroviral Reyataz

Bristol-Myers Squibb on Friday announced that it has received FDA approval for a single 300 mg capsule formulation of its protease inhibitor Reyataz to be taken as part of combination therapy, Reuters reports.

24 Oct 2006

Treatments used for SARS no benefit to victims

Researchers have found, following a systematic review of all studies done on the 2003 SARS epidemic, that none of the treatments used to treat patients appear to have worked.

13 Sep 2006

SARS: Systematic review of treatment effects

The SARS virus set alarm bells ringing across the world when it first appeared in 2002, but now a review of the effectiveness of the treatments used against it has found no evidence that any of them worked.

12 Sep 2006

Researchers find way to decrease risk of atherosclerosis that accompanies long-term use of protease inhibitors

Physiologists may have found a way to decrease the risk of hardening of the arteries that accompanies the long-term use of protease inhibitors, a class of drugs that has emerged as the most effective treatment against HIV and AIDS.

5 Sep 2006

Simpler and less expensive method of controlling the progression of HIV

There might be a simpler and less expensive method of controlling the progression of HIV, according to several preliminary studies presented last Thursday at the XVI International AIDS Conference in Toronto, the Los Angeles Times reports (Chong, Los Angeles Times, 8/18).

20 Aug 2006

FDA approves Prezista (darunavir)

FDA approves Prezista (darunavir), a new drug for adults whose infection with the human immunodeficiency virus (HIV) has not responded to treatment with other antiretroviral drugs.

26 Jun 2006

Tibotec Pharmaceuticals receives NDA for investigational HIV protease inhibitor

Tibotec Pharmaceuticals has announced that the New Drug Application (NDA) for TMC114, an investigational HIV protease inhibitor, has been accepted for priority review by the United States Food and Drug Administration (FDA).

7 Mar 2006

HIV/AIDS drugs may also be effective against malaria

Researchers at The Queensland Institute of Medical Research (QIMR) have found that drugs used to treat HIV Aids may also be effective against the biggest killer in the world - malaria.

2 Jun 2005

FDA recommends approval of the investigational anti-HIV drug tipranavir

Boehringer Ingelheim today announced that the U.S. Food and Drug Administration's (FDA) Antiviral Drugs Advisory Committee recommended the approval of the investigational anti-HIV drug tipranavir (11-3). Tipranavir is a non-peptidic protease inhibitor that requires boosting with low-dose ritonavir and must be used in combination with other antiretroviral agents.

20 May 2005

Roche to discontinue the sale and distribution of Fortovase (saquinavir)

Roche announced today that it has decided to discontinue the sale and distribution of Fortovase (saquinavir), as clinical demand for the drug has declined significantly due to the availability of a new formulation of Invirase (saquinavir mesylate), which increasingly has become the preferred formulation of saquinavir.

18 May 2005

New compounds for the treatment of HIV/AIDS

Scientists from Tibotec Pharmaceuticals Ltd. presented data on several new compounds for the treatment of HIV/AIDS at the 12th Conference on Retroviruses and Opportunistic Infections (CROI), held February 22-25 in Boston, MA, USA.

27 Feb 2005

HIV drugs known as protease inhibitors also protect against Malaria

Scientists from The Queensland Institute of Medical Research (QIMR) have found that a group of HIV drugs known as protease inhibitors may also be effective for treating or preventing malaria.

11 Nov 2004