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Italian study evaluates COVID-19 reinfection risk among previously infected and vaccinated individuals

Researchers from Italy investigated the risk of SARS-CoV-2 reinfection and hospitalization among individuals with vaccinations and previous SARS-CoV-2 infections.

31 Oct 2022

Study refutes the nicotinic hypothesis of SARS-CoV-2 infection mechanism

A new study confirmed that the SARS-CoV-2 spike protein does not bind to human AChR’s orthosteric sites, nor does it compete with ACh, choline, or nicotine.

28 Oct 2022

Ancient viral DNA in human genomes protects cells against present-day viruses

Viral DNA in human genomes, embedded there from ancient infections, serve as antivirals that protect human cells against certain present-day viruses, according to new research.

27 Oct 2022

Increased Gibbs energy of binding indicates greater infectivity of SARS-CoV-2 BA.2.75

Researchers explore the thermodynamic properties of the SARS-CoV-2 Omicron subvariant BA.2.75 to understand its increased transmissibility.

27 Oct 2022

Study finds that ACE-2 is not biochemically required for SARS-CoV2 membrane fusion

A study tested the hypothesis that the ACE-2 receptor of SARS-CoV-2 is not only an attachment factor in viral infection but also plays a role in activating the viral spike protein to facilitate membrane fusion.

27 Oct 2022

Some healthcare workers vaccinated against COVID-19 show unexpectedly low responses to immunizations

A subset of healthcare workers vaccinated against COVID-19 had unexpectedly low responses to the immunizations, according to Cedars-Sinai investigators.

27 Oct 2022

How important is sterilizing immunity in protection against SARS-CoV-2?

The authors discussed the underlying principles of sterilizing immunity and its importance in protecting individuals against SARS-CoV-2 reinfections during the COVID-19 pandemic.

26 Oct 2022

Omicron BA.4/BA.5 bivalent mRNA vaccine booster elicits similar neutralizing antibody responses to monovalent vaccine

Researchers analyzed the antibody response induced by the new bivalent mRNA SARS-CoV-2 vaccines in individuals who have been fully vaccinated with monovalent vaccines and those who have had breakthrough infection with the SARS-CoV-2 Omicron BA.4/BA.5 variants.

26 Oct 2022

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

Researchers analyzed the phenotypes of the SARS-CoV-2 variants of concern (VOCs), the molecular responses to infections from these VOCs, and the evolving virus-host interactions using a comparative genomic and proteomic approach.

26 Oct 2022

SARS-CoV-2 BQ.1 variant cases may increase in Europe

A recent epidemiological update by the European Center for Disease Prevention and Control indicated that a new SARS-CoV-2 Omicron sublineage was likely to increase COVID-19 case numbers.

26 Oct 2022

Using a nanotechnology-packed bubble to detect SARS-CoV-2 virus

Scientists have shown that they can detect SARS-CoV-2, the virus that causes COVID-19, in the air by using a nanotechnology-packed bubble that spills its chemical contents like a broken piñata when encountering the virus.

25 Oct 2022

Is there a difference in the risk of hospital admission between BA.1 and BA.2 cases treated with Sotrovimab?

Researchers compared the risk associated with hospitalization of sotrovimab-treated individuals infected with SARS-CoV-2 Omicron variants.

25 Oct 2022

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

Researchers designed a COVID-19 vaccine construct using hybrid SARS-CoV-2 S protein (containing SARS-CoV-2 Delta and Omicron variant mutations) and N protein peptides that confer T lymphocyte-mediated immune protection.

25 Oct 2022

Study reveals how SARS-CoV-2 infection of macrophages promotes inflammatory responses

Dysregulation of macrophages during SARS-CoV-2 infection and the over-exuberant production of pro-inflammatory cytokines by these macrophages has been hypothesized to contribute to severity of COVID-19 disease.

25 Oct 2022

What is the efficacy of mulberry component Kuwanon C against COVID-19?

A recent study determined the underlying antiviral mechanism of KC associated with the inhibition of SARS-CoV-2.

24 Oct 2022

Longitudinal cohort study of primary healthcare workers reveals long-lasting SARS-CoV-2 humoral immunity in the absence of vaccination

Researchers performed a longitudinal cohort study to assess the levels of immunoglobulins M (IgM), G (IgG), and A (IgA) against the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

24 Oct 2022

Booster vaccinations in the elderly lead to impaired neutralization of SARS-CoV-2 and atypical B cells

Researchers examine neutralizing antibody responses against SARS-CoV-2 in elderly individuals who received one mRNA booster dose.

23 Oct 2022

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

Researchers at Boston University made a chimeric recombinant SARS-CoV-2 encoding the spike glycoprotein gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate.

22 Oct 2022

Breakthrough infection risk and immune responses to vaccines associated with human leukocyte antigen alleles

Researchers from the U.K. used data from clinical trials of the Oxford-AstraZeneca COVID-19 vaccine ChAdOx1 nCoV-19 to understand the genetic factors contributing to the individual variations in the antibody responses to the vaccine.

20 Oct 2022

Research uncovers mechanisms governing SARS-CoV-2 Omicron subvariant entry

In a recent study posted to the bioRxiv* preprint server, researchers at Ohio State University and the University of Texas Medical Branch assessed the underlying mechanisms involved in the fusogenicity and endosomal entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants.

20 Oct 2022

Spike Protein News and Research

Italian study evaluates COVID-19 reinfection risk among previously infected and vaccinated individuals

Study refutes the nicotinic hypothesis of SARS-CoV-2 infection mechanism

Ancient viral DNA in human genomes protects cells against present-day viruses

Increased Gibbs energy of binding indicates greater infectivity of SARS-CoV-2 BA.2.75

Study finds that ACE-2 is not biochemically required for SARS-CoV2 membrane fusion

Some healthcare workers vaccinated against COVID-19 show unexpectedly low responses to immunizations

How important is sterilizing immunity in protection against SARS-CoV-2?

Omicron BA.4/BA.5 bivalent mRNA vaccine booster elicits similar neutralizing antibody responses to monovalent vaccine

Study reveals conserved and divergent host responses to infections with SARS-CoV-2 variants of concern

SARS-CoV-2 BQ.1 variant cases may increase in Europe

Using a nanotechnology-packed bubble to detect SARS-CoV-2 virus

Is there a difference in the risk of hospital admission between BA.1 and BA.2 cases treated with Sotrovimab?

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

Study reveals how SARS-CoV-2 infection of macrophages promotes inflammatory responses

What is the efficacy of mulberry component Kuwanon C against COVID-19?

Longitudinal cohort study of primary healthcare workers reveals long-lasting SARS-CoV-2 humoral immunity in the absence of vaccination

Booster vaccinations in the elderly lead to impaired neutralization of SARS-CoV-2 and atypical B cells

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

Breakthrough infection risk and immune responses to vaccines associated with human leukocyte antigen alleles

Research uncovers mechanisms governing SARS-CoV-2 Omicron subvariant entry

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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