Thromboembolism News and Research

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Isis commences ISIS-FXIRx Phase 2 study in knee replacement surgery patients

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 2 comparator-controlled study evaluating ISIS-FXIRx in patients undergoing knee replacement surgery, also referred to as total knee arthroplasty (TKA).

29 Oct 2012

VTE care improvements may be linked to implementation of treatment guidelines

The quality of care of patients hospitalized with venous thromboembolism (VTE) significantly improved between 2005 and 2009, and researchers suggest these improvements may be due to the implementation of VTE treatment guidelines.

22 Oct 2012

Obesity does not affect VTE risk after knee surgery

Being morbidly obese does not increase the risk for developing venous thromboembolism after total knee arthroplasty surgery, report US researchers.

15 Oct 2012

Best-practices protocol significantly reduces ventilator-associated pneumonia

An intensive care unit-initiated protocol implementing “best practices” significantly reduces ventilator-associated pneumonia, research shows.

8 Oct 2012

VTE risk highlighted for rheumatoid arthritis patients

Individuals with rheumatoid arthritis are at an increased risk for venous thromboembolism, research confirms.

8 Oct 2012

Patients with RA more likely to develop venous thromboembolism

A study that included more than 45,000 residents of Sweden with rheumatoid arthritis finds that individuals with this disease had an associated higher risk of venous thromboembolism (a blood clot that forms within a vein), and that this elevated risk was stable for 10 years after the time of diagnosis, according to a study in the October 3 issue of JAMA.

3 Oct 2012

Warfarin therapy should not be stopped completely after GI bleeding

The decision to not resume warfarin therapy following a gastrointestinal bleeding event is linked to an increased risk for thrombosis and mortality, researchers suggest.

27 Sep 2012

Warfarin therapy should not be stopped completely after GI bleeding

The decision to not resume warfarin therapy following a gastrointestinal bleeding event is linked to an increased risk for thrombosis and mortality, researchers suggest.

25 Sep 2012

Many AF patients not receiving oral anticoagulant therapy despite rapid adoption of dabigatran

A novel blood thinner recently approved by the FDA, dabigatran (Pradaxa), has been rapidly adopted into clinical practice, yet thus far has had little impact on improving treatment rates for atrial fibrillation.

24 Sep 2012

Measures of kidney function may be linked to thrombosis

Estimated glomerular filtration rate and albumin-creatinine ratio are independently associated with venous thromboembolism, research suggests.

18 Sep 2012

Measures of kidney function may be linked to thrombosis

Estimated glomerular filtration rate and albumin-creatinine ratio are independently associated with venous thromboembolism, research suggests.

18 Sep 2012

Apixaban offers minor added benefit for adult patients after hip replacement

The clot-inhibiting drug apixaban was approved in May 2011 for the prevention of thrombosis (blood clots) after operations to replace a hip or knee joint.

18 Sep 2012

Dabigatran increasingly being used off-label

Dabigatran has increasingly been used for off-label indications, including venous thromboembolism, in the USA between 2007 and 2011, a study suggests.

13 Sep 2012

Early CATCH improves thrombocytopenia outcomes

One in five patients using heparin to protect against venous thromboembolism develops thrombocytopenia, reveal results from the CATCH Registry.

12 Sep 2012

Female sex associated with increased risk of stroke for AF patients aged ≥75 years

Female gender increases the risk of stroke in patients with atrial fibrillation (AF) aged >75 years by 20%, according to a study presented today at the ESC Congress 2012. The findings were presented by Anders Mikkelsen, from Denmark.

27 Aug 2012

CKD may raise stroke, bleeding risk in AF patients

Danish study results show that the presence of chronic kidney disease appears to raise the risk for stroke, systemic thromboembolism, and bleeding among patients with atrial fibrillation.

22 Aug 2012

CKD may raise stroke, bleeding risk in AF patients

Danish study results show that the presence of chronic kidney disease appears to raise the risk for stroke, systemic thromboembolism, and bleeding among patients with atrial fibrillation.

21 Aug 2012

Dabigatran ‘still effective in obese’

The oral direct thrombin inhibitor dabigatran is an effective thromboprophylactic therapy for patients undergoing total hip or knee replacement regardless of their body mass index, researchers assert.

9 Aug 2012

Low blood anticoagulant levels increase risk for VTE

Low plasma levels of antithrombin, protein C, and protein S significantly increase the risk for venous thromboembolism, Italian research shows.

25 Jul 2012

HAS-BLED: Atrial fibrillation patients undergoing angioplasty can still take anticoagulants

Researchers say that oral anticoagulation could improve the prognosis of atrial fibrillation patients who undergo percutaneous coronary intervention, even if they have a high bleeding risk according to the HAS-BLED score.

19 Jul 2012