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Study suggests Golgi as potential drug target for Alzheimer's treatment

Alzheimer's disease (AD) progresses inside the brain in a rising storm of cellular chaos as deposits of the toxic protein, amyloid-beta (Aβ), overwhelm neurons. An apparent side effect of accumulating Aβ in neurons is the fragmentation of the Golgi apparatus, the part of the cell involved in packaging and sorting protein cargo including the precursor of Aβ. But is the destruction the Golgi a kind of collateral damage from the Aβ storm or is the loss of Golgi function itself part of the driving force behind Alzheimer's? This was the question for Yanzhuang Wang, Gunjan Joshi, and colleagues at the University of Michigan, Ann Arbor, as they set out to uncover the mechanism damaging the Golgi, using a transgenic mouse and tissue culture models of AD to look at what was going on.

6 Dec 2014

Genetics may play major role in Lou Gehrig's disease, study reveals

Genetics may play a larger role in causing Lou Gehrig's disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive genetic studies to date of patients who suffer from the condition also known as amyotrophic lateral sclerosis, or ALS.

6 Dec 2014

Research findings may lead to new ways to thwart drug resistance

Penicillin, the wonder drug discovered in 1928, works in ways that are still mysterious almost a century later. One of the oldest and most widely used antibiotics, it attacks enzymes that build the bacterial cell wall, a mesh that surrounds the bacterial membrane and gives the cells their integrity and shape. Once that wall is breached, bacteria die -- allowing us to recover from infection.

6 Dec 2014

Study sheds new light on well-known mechanism required for immune response

A new study published in the scientific journal Proceedings of the National Academy of Sciences of the United States of America sheds new light on a well-known mechanism required for the immune response. Researchers at the IRCM, led by Tarik Möröy, PhD, identified a protein that controls the activity of the p53 tumour suppressor protein known as the "guardian of the genome".

6 Dec 2014

Researchers suggest new strategy to control cellular identity and fate

A team of scientists that included researchers from UCLA has discovered a novel mechanism of RNA regulation in embryonic stem cells. The findings are strong evidence that a specific chemical modification, or "tag," on RNA plays a key role in determining the ability of embryonic stem cells to adopt different cellular identities.

6 Dec 2014

Researchers identify important neural mechanism responsible for certain chronic pain disorders

Pain typically has a clear cause-but not always. When a person touches something hot or bumps into a sharp object, it's no surprise that it hurts. But for people with certain chronic pain disorders, including fibromyalgia and phantom limb pain, a gentle caress can result in agony.

6 Dec 2014

Cellular Research announces commercial availability of Precise targeted RNASeq assays

Cellular Research today announced the commercial launch of its Precise targeted RNASeq assays. The company also announced the commercial availability of application-focused panels for the Precise assays, including panels designed for oncology, induced pluripotent stem cells and immunology.

5 Dec 2014

Janssen, American Diabetes Association team up to launch national educational campaign on diabetes

Janssen Pharmaceuticals, Inc. today announced a collaboration with the American Diabetes Association to launch Teaming Up to Take On Diabetes, a national educational campaign intended to help the nearly 30 million Americans living with diabetes better understand and manage the disease.

5 Dec 2014

Leica Microsystems offers preview of light sheet module for confocal microscope at ASCB annual meeting

At the annual meeting of the American Society for Cell Biology (ASCB) in Philadelphia, PA, USA, from December 6 to 10, 2014, Leica Microsystems offers visitors a preview of its latest development: a light sheet module as an optional add-on to the Leica TCS SP8 confocal microscope for the observation of developing organisms in real time and 3D. The synergy of light sheet and confocal microscopy opens novel fields of application.

From Leica Microsystems GmbH 5 Dec 2014

Pharmacyclics launches informCLL registry to explore natural history of CLL patients

Pharmacyclics, Inc. today announced the launch of informCLL, a large, observational, prospective registry that will explore the natural history of chronic lymphocytic leukemia (CLL), examine how IMBRUVICA (ibrutinib) and other approved targeted therapies are being used to treat patients with CLL, and provide a comparison to treatments using conventional chemoimmunotherapy (CIT).

5 Dec 2014

Landmark CoMMpass Study data now available through MMRF Researcher Gateway

The Multiple Myeloma Research Foundation announced today that new data from the landmark CoMMpass Study is now available to researchers via the MMRF's Researcher Gateway, an online, open-access portal designed to make key genomic and clinical data publically available for additional study.

5 Dec 2014

Hormone leptin increases blood pressure that occurs with weight gain

Leptin, a hormone that regulates the amount of fat stored in the body, also drives the increase in blood pressure that occurs with weight gain, according to researchers from Monash University and the University of Cambridge.

5 Dec 2014

Researchers discover link between obesity and hypertension

The link between obesity and cardiovascular diseases is well acknowledged. Being obese or overweight is a major risk factor for the development of elevated blood pressure, and cardiovascular diseases. But it has net been known how obesity increases the risk of high blood pressure, making it difficult to develop evidence based therapies for obesity, hypertension and heart disease.

5 Dec 2014

Scientists seek to improve stem cell transplant outcomes using DNA sequencing, mathematical modeling

Is the human immune system similar to the weather, a seemingly random yet dynamical system that can be modeled based on past conditions to predict future states? Scientists at VCU Massey Cancer Center's award-winning Bone Marrow Transplant (BMT) Program believe it is, and they recently published several studies that support the possibility of using next-generation DNA sequencing and mathematical modeling to not only understand the variability observed in clinical outcomes of stem cell transplantation, but also to provide a theoretical framework to make transplantation a possibility for more patients who do not have a related donor.

5 Dec 2014

Scientists uphold mouse model of human disease, but pinpoint vital differences in gene expression

Scientists at Penn State College of Medicine, working alongside an international team of researchers, have produced the most complete encyclopedia of functional elements in the mouse genome to date and compared it to the human genome.

5 Dec 2014

Research to Prevent Blindness, IRRF partner to advance knowledge about AMD

Research to Prevent Blindness, the leading eye research foundation, is partnering with the International Retinal Research Foundation to advance knowledge about age-related macular degeneration (AMD) through novel stem cell research.

5 Dec 2014

TSRI scientists identify 'mechanoreceptor' protein that mediates sense of touch in mammals

A team led by biologists at The Scripps Research Institute has solved a long-standing mystery in neuroscience by identifying the "mechanoreceptor" protein that mediates the sense of touch in mammals.

5 Dec 2014

UH professors receive NIH grant to combat drug-resistant bacteria

Addressing the relentless game of cat and mouse played between antibiotics and bacteria, a pair of University of Houston professors recently received a $519,000 grant from the National Institutes of Health.

5 Dec 2014

New single-cell genetic profiling techniques help uncover variation in pluripotent stem cells

Stem cells offer great potential in biomedical engineering due to their pluripotency, which is the ability to multiply indefinitely and also to differentiate and develop into any kind of the hundreds of different cells and bodily tissues. But the precise complexity of how stem cell development is regulated throughout states of cellular change has been difficult to pinpoint until now.

5 Dec 2014

Landmark call for neurodegenerative disease research

The EU Joint Programme - Neurodegenerative Disease Research has announced a EUR 30 million call for neurodegenerative disease research topped-up with EUR 10 million from the Horizon 2020 framework programme for research and innovation of the European Union.

4 Dec 2014

Cell News and Research

Study suggests Golgi as potential drug target for Alzheimer's treatment

Genetics may play major role in Lou Gehrig's disease, study reveals

Research findings may lead to new ways to thwart drug resistance

Study sheds new light on well-known mechanism required for immune response

Researchers suggest new strategy to control cellular identity and fate

Researchers identify important neural mechanism responsible for certain chronic pain disorders

Cellular Research announces commercial availability of Precise targeted RNASeq assays

Janssen, American Diabetes Association team up to launch national educational campaign on diabetes

Leica Microsystems offers preview of light sheet module for confocal microscope at ASCB annual meeting

Pharmacyclics launches informCLL registry to explore natural history of CLL patients

Landmark CoMMpass Study data now available through MMRF Researcher Gateway

Hormone leptin increases blood pressure that occurs with weight gain

Researchers discover link between obesity and hypertension

Scientists seek to improve stem cell transplant outcomes using DNA sequencing, mathematical modeling

Scientists uphold mouse model of human disease, but pinpoint vital differences in gene expression

Research to Prevent Blindness, IRRF partner to advance knowledge about AMD

TSRI scientists identify 'mechanoreceptor' protein that mediates sense of touch in mammals

UH professors receive NIH grant to combat drug-resistant bacteria

New single-cell genetic profiling techniques help uncover variation in pluripotent stem cells

Landmark call for neurodegenerative disease research

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